Maria Cristina Trueba

Kelly Stecker,
@maltelaar.bsky.social, @hecklab.bsky.social, @vadim-demichev.bsky.social, @coxlab.bsky.social, @slavov-n.bsky.social, @mannlab.bsky.social,
@jespervolsen.bsky.social
Krijgsveld Lab,
Either in person or their online materials / papers were extremely useful!

Life hack: write down stuff you’ve already done on your to-do list and slam a checkmark on it

Doing this for years

Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
doi.org/10.1101/2025...

Something to deffinitely have in mind!

I recently discovered Goodreads, and I am so sad I want to read much more books than the ones I have the capacity to actually read atm. #Goodreads #books

Absence of ICAM-1 drives tumor resistance to T and NK cell-mediated killing, with LFA-1 engager molecular potentiating anti-tumor immunity by re-engaging this synaptic interaction @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

T cells acquire both TCRs and CARs from other activated T cells by trogocytosis. Notably, this trogocytosis does not need a cognate receptor/ligand. Modifying CAR transmembrane domains makes trogocytosis more/less likely.

@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...

More of these examples are needed

Is a good #FluorescentFriday the best thing ever?? Yes, it is. 👏 #Cellimaging #Research #PhD

🚨 Save the Date! NVMS Spring Meeting 2025, 26th May 🚨
Mark your calendars! 📅 The NVMS Spring Meeting is on 26th May at Sanquin, Amsterdam. Stay tuned for details on abstract submissions and the program. Let's explore the latest mass spec research in the Netherlands! 🔬⚡😀

#NVMS #MassSpec

The controls that got out of control: How failed control experiments paved the way to transformative discoveries: EMBO reports: Vol 0, No 0 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Despair not (yet)
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."

Cancer cells ‘poison’ the immune system with tainted mitochondria Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Really interesting paper 🧪 🤩

Immune evasion through mitochondrial transfer 😮

Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity

www.nature.com/articles/s41...

www.nature.com/articles/d41...

@nature.com

🗺 I'm deeply saddened about the recent government's decisions on science budgets. First NL and then US. Without science, there is no future.

🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.

We built a rust library (rustyms) and the Annotator GUI to analyze any complex bottom-up or top-down peptidoform with any fragmentation based on ProForma 2.0.
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...

The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!

YouTube video by ARTEde Der Proteom-Code - Dem Geheimnis des Lebens auf der Spur | Doku HD | ARTE

Arte (🇫🇷/🇩🇪 TV channel) just posted a documentary on proteomics on YouTube. Of course somewhat simplified but it’s nice to see our research explained in simple terms for the masses. If you have some time (or want to practice your German), it’s definitely worth watching:

m.youtube.com/watch?v=lVkb...

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus Natural killer (NK) cells are specialized lymphocytes that help protect against viruses and cancer. However, in the context of bacterial infections, NK cells can be harmful, rather than protective. Su...

NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus

Now on bioRxiv.

@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social

Had a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆

🇪🇺I'm honoured to be talking about our work in immuno-oncology proteomics at RadioLibertad España with Antonio Gonzalez Armas

🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas

Let's keep sharing science!

REVIEW: Next-generation combination approaches for immune checkpoint therapy
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social

Different forms of mentoring Image Source: https://frntofficesport.com/wp-content/uploads/2018/02/mentoring-dr.-sara-taylor-1024x784.jpg

Faculty mentoring in academic institutions, a thread.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.

An infrared photo of a rainbow: a strange, ghostly-looking rainbow in a mostly black and white photo, with a faintly red outer edge and a cyan inner edge, and what look like a few even fainter ‘echo’ bows inside

A regular visible-light pic of a rainbow

An ultraviolet picture of a rainbow: a dark, foreboding landscape with a deep purple stripe emanating from it, and a grey stripe inside

A composite of the three preceding photos, showing that the infrared bow is ‘outside’ the visible light rainbow, and the ultraviolet bow ‘inside’

There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet.

Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.

🧪 #photography

PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!

Like ‘old Twitter’: The scientific community finds a new home on Bluesky After recent changes to Elon Musk’s X, a gradual migration turns into a stampede

It does have to be said that Bluesky is feeling like a great place to hang out and talk science 🧪

The eLife Model: An update on progress following changes in Web of Science indexing status Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to…

Following the news that eLife will not receive an Impact Factor in 2025, we’ve shared an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to now. Find out more.
https://buff.ly/3ATRAFT

Beyond the binary: How my intersex identity shaped my path in evolutionary biology | Royal Society Claudia Astorino (she/her, they/them) discusses how her intersex identity motivated her to explore intersex variation through the lens of evolutionary biology.

I am proud to be one of several #LGBTQIA scientists featured by the Royal Society for Int’l #LGBTQIAinSTEMDay! 🌈

I talk ab how being #intersex has informed my research interests as an evolutionary biologist & biological anthropologist and how I do science 🟨🙆‍♀️🟨 #IntersexInSTEM #QueerInSTEM

Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network

Below are the links

If you're an immunologist and I have missed you so far, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

Now that I've fled Leon's site for bluer skies, I'm sure I'll be called an #Ex-X, but personally, I'll always consider myself a #TwitterQuitter.