Charlie Harper

It's no longer binary: normal or abnormal.
We've known that A.I. can predict future risk of breast cancer from a mammogram
jamanetwork.com/journals/jam...
Today the FDA approved an A.I. to do this for 5-year risk assessment
clairity.com @connielehman.bsky.social

It’s the hardest thing to balance within you the full acknowledgement of how unfair humans are to their fellow humans with the full trust that humanity can be the most powerful tool for justice.

Patients who experience a transient ischemic attack (TIA) or minor stroke face a high risk of subsequent strokes, emphasizing the need for both short-term and long-term prevention strategies.

ja.ma/4kA2xhh

Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis | NEJM Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). In this ongoing phase 3, multicenter, randomize...

New @nejm.org
Another win for semaglutide (Ozempic) and the GLP-1 drugs: reduction of liver fibrosis in MASH
www.nejm.org/doi/full/10....

PhD Student, Ella Howes, has just released the latest episode of the Trials Methodology podcast with our very own @willjcragg.bsky.social , covering all things to do with the 'how' of trials methodology💡

Give it a listen here (or on Apple podcasts if you prefer): open.spotify.com/episode/04JZ...

“Yes, I deserve a spring - I owe nobody nothing.”

Virginia Woolf

UK academia pretends to be a business by maximising threats and minimising incentives for its staff.

That’s not how successful businesses run.

Lotte Bjerre Knudsen: The Scientist Who Drove GLP-1 Drugs For Obesity and Alzheimer's Facts, data, and analytics about biomedical matters.

The scientist who is responsible for driving GLP-1 drugs for the treatment of obesity and testing them for prevention of Alzheimer's disease—Lotte Bjerre Knudsen— tells her story in a remarkable conversation. Full transcript, or video, all free, no ads.
erictopol.substack.com/p/lotte-bjer...

11 clinical trials to watch in 2025
nature.com/articles/s41...
@naturemedicine.bsky.social

Definitions of clinical study outcome measures for cardiovascular diseases: the European Unified Registries for Heart Care Evaluation and Randomized Trials (EuroHeart), by Chris Wilkinson et al academic.oup.com/eurheartj/ad...

Aspirin for *primary prevention* of cardiovascular disease has been shown to cause more bleeding than benefit in randomized trials over the past 5 years. But it's still being taken by 1 of 3 older Americans.
www.acpjournals.org/doi/abs/10.7...

Real-time Adaptive Randomization of Clinical Trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Some superiority trials with non-significant results published in high impact factor journals correspond to non-inferiority situations: a research-on-research study Many negative randomized controlled trials (RCTs) report spin in their conclusions to highlight the benefits of the experimental arm, which could correspond to a non-inferiority (NI) objective. We aim...

Some superiority trials with non-significant results published in high impact factor journals correspond to non-inferiority situations: a research-on-research study - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Correct link: www.jclinepi.com/article/S089...

A methodological review identified several options for utilizing registries for randomized controlled trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

I would be very cautious about these numbers. UKB not yet mature enough for Alzhrimers studies.

100% agree with this. Speaking from personal experience the "grin and bear it" mentality with work just isn't good enough

Featured Science Sim Pub with #AHA24 from @PabloMikiMarti & @scottdsolomon et al published in #CircHF:
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials
#AHAJournals

Read more: https://ahajrnls.org/40Q1DpV

A breakthrough cancer immunotherapy is now taking aim at autoimmune disease CAR-T therapy is generating excitement for lupus, scleroderma, and other conditions as clinical trials expand

This is huge news.

This opens up the possibility of a viable treatment for a range of auto-inmune diseases, not just Lupus.

www.science.org/content/arti...

Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity | NEJM Obesity increases the risk of heart failure with preserved ejection fraction. Tirzepatide, a long-acting agonist of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor...

Another GLP-1 drug success. Tirzepatide in heart failure with preserved ejection fraction (HFpEF) with longer term follow-up than 2 previous trials with semaglutide
nejm.org/doi/full/10....
in people with BMI >30; no data yet for HFpEF in people without obesity

To conclude our Pirates series, our newest Empire episode looks into the real history behind one of the most famous fictional pirates - Captain Hook.

Peter Pan is a story that has continued to inspire generations, but the truth behind its creation is wrapped up in tragedy and darkness...

🧚🏴‍☠️🧚🏴‍☠️🧚🏴‍☠️🧚🏴‍☠️

A large randomized trial in people with Type 2 diabetes showed intensive BP lowering (systolic < 120 mm Hg) reduced major cardiovascular outcomes
www.nejm.org/doi/full/10....