Marcel Issler

Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social

So curious to see whats possible with the latest and greatest tech in microscopy! Go Lucien!

YouTube video by Pertz Lab Smart microscopy, computer vision, and controlling cells with light -- my PhD thesis in 3 minutes

Won best thesis award with this video! 4 years of research and play in 3 minutes :')
youtu.be/so0fPlK1-LM

Uni Bern: PhD Position in Statistics with a focus on Statistical Machine Learning for Self-Driving Microscopy

🔬📊 PhD (100%) – Statistics & ML for self-driving microscopy

Joint PhD with David Ginsbourger (Stats) & Pertz Lab (Cell Biology).
Gaussian Processes, Bayesian design, active learning on live-cell experiments.

ohws.prospective.ch/public/v1/jo...

#PhD #Statistics #MachineLearning #Bayesian

About microfabrication
bsky.app/profile/epim...

📚 Welcome to the Epithelial Mechanics Fan Club! 🌟

We're all about sharing research papers and threads. If you'd like to contribute, please send DM us! 💬

Our goal is to build a community that fosters knowledge sharing.

Explore our previous 🧵 here 👇

»Die extremen Auswüchse der neuen Wissenschaftsfeindlichkeit lassen sich bereits jetzt in den USA beobachten. Hier in Berlin- Mitte, rund um die Luisenstraße, haben wir die alten Charité-Hörsäle, in denen die Porträts hängen – von den Kollegen, die in den dreißiger Jahren die Charité verlassen mussten. Auch wenn die Motive heute andere sind: Wir alle innerhalb der Wissenschaft sollten nicht glauben, dass sich solche Dinge in ihren Grundzügen nicht wiederholen können.« Christian Drosten https://www.diw.de/de/diw_01.c.932545.de/100_jahre_diw/wissenschaft_ist_freiheit_und_pflicht.html

#Wissenschaftsfeindlichkeit @cdrosten.bsky.social

Looks like someone is misusing GloBIAS and its president name to approach people for money transfers. Please note - GloBIAS will always send proper payment requests and has no need for members and volunteers to transfer money on their behalf.

is there a direct crosstalk between actin and vimentin intermediate filaments? Our work shows that vimentin promotes actin assembly by stabilizing ATP-subunits at the barbed end.
Fantastic work done by @lilianpaty.bsky.social with @romet-jegou-lab.bsky.social

www.biorxiv.org/content/10.1...

Where are you! Can't wait :)

😍 🩷 A little sneak peak of #cellmech2025

Shroff, N. P., Xu, P., Kim, S., Shelton, E. R., Gross, B. J., Liu, Y., ... & Klein, O. D. (2024). Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nature cell biology, #EpithelialMechanics www.nature.com/articles/s41...

We're looking for highly motivated candidates for PhD positions in the physics of living systems.

Our group uses theoretical physics to understand how cells collectively self-organize.

If you're interested, get in touch & check out the Biozentrum PhD Fellowship program, deadline October 12th!

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...

Visual of segmented human induced pluripotent stem cells with the key workshop dates: Symposium on November 10-11, Hackathon on November 12-14th in Zurich Switzerland

We're happy to announce the 2025 International OME-NGFF workshop 🎉

📅 Dates:
- Symposium: Nov 10–11, 2025
- Hackathon: Nov 12–14, 2025

📍 Location: Zurich, Switzerland

Full details & registration: www.biovisioncenter.uzh.ch/en/events/Up... 

#bioimaging #openscience #OMENGFF #OMEZarr

(1/x 🧵)

Very happy to see it out, another fun collaboration with the Sixt group at @istaresearch.bsky.social ! See Mehmet's thread for a summary of how different immune cells can "surf" on each other's self-generated gradients to drive efficient co-migration!

Figures from the mentioned paper showing FLIM curve and its derivative.

Oh, nice, just found a paper from @joergenderlein.bsky.social and co on blind estimation of IRF for FLIM measurements pmc.ncbi.nlm.nih.gov/articles/PMC...
It should be useful!

A modified Simpsons scene: Homer in the bathtub, and Bart with a chair (Homer labeled as Protein Minding its own business, Bart labeled as Kinase, with an ATP). The next panel shows Bart hitting Homer with the chair and the ATP turning into ADP and a P

Have we started the science shitposting yet

Waiting for Sam to tell us that GPT-6 will be Nobel level of intelligence and that it can see more colours than a mantis shrimp

for MCF10A also seems to be dependent a lot on density! looks very different compared to this (over)confluent epithelia i imaged some time ago on confocal. +1 for zarr+dask, has been working great for us with on data 👌 any tricks on how to convert .czi to .zarr without loosing compression?

In my experience the default zarr already scores quite efficiency on disk, but thats for data that has lots of zeros. In terms of czi conversion i would use the bioio package. However i don't know if you can maintain the compression. Otherwise native zarr supports zipstore, which might help.

Nice! Indeed nuclei are pancakes when they are not inside a 3D matrix, since glass or hard plastic is incredibly charged, pulling all towards the interface. Regarding the big files, i suggest to use zarr and dask, seems like the whole field is moving there.

first data from the new LLSM in PertzLab @olivierpertz.bsky.social! i always thought nuclei were spherical but they are pancakes???? so much more to see in 3d, but data volume produced is insane, we will have to rethink our analysis pipelines. tips welcome! here shown in @napari.org

🚀 Big news! The napari hub has been reimplemented and is now community-run! :tada: It's still the go-to place for finding and sharing napari plugins, but the website is now snappier and lighter-weight. Check it out 👉 www.napari-hub.org

Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧵 with pressure control, multiscale buckling, controlled wrinkling

Morphodynamics of human early brain organoid development - Nature Human brain morphodynamics are explored using organoids.

Very happy to share it’s online! If you read the preprint, updates include tracking cells and tissue flow, Histo4i timecourse (69 Abs) comparing spatial patterning emergence and a new WLS KO ipsc line establishing mechanosensing via YAP-WLS/WNT caudalizes organoids www.nature.com/articles/s41...

The 2025 VIB.AI International PhD Call closes June 22nd.

We’re offering 4 fully funded PhD positions across labs tackling big questions in biology with AI and machine learning, covering protein design, computational neuroscience, gene regulation, and more.
👉 https://tinyurl.com/53nc9vnd

Unfortunately, we need to cancel the upcoming #GloBIAS seminar. Please check our webpage: www.globias.org/activities/b... for updates/ new date for this session.

Hey bioimaging folks, join us for the next OME-NGFF Community Call on June 24 at 9:00 CEST and 17:00 CEST!

Details and agenda on the one and only image.sc here: forum.image.sc/t/join-us-fo...

🧠 Interested in extending #Zarr?

Let us know what you think about ZEP10 "Generic extensions". Current plan is for voting on the proposal mid-June. 📅

github.com/zarr-develop...