Tim Bussey

12 episodes coming out! how lucky am I? I got to interview 🤩 experts in psychiatry, gynecology, global health, nephrology, neuroscience, microbiome, FemTech, charitiable giving, & policy...join us for sometimes intense, but always informative conversations, sprinkled with some laughs along the way!

#fluorescencefriday shows the intimate relationship between astrocytes, (cyan) microglia (green) and amyloid plaques (magenta). we find that in APOE4 mice there is much more glia associated with plaques.

New series coming up where we highlight Bussey-Saksida Touchscreen Chamber tasks!

First is the 4-Choice Gambling Task! This task is used to investigate decision-making which can be implicated in many neurological and psychiatric disorders.

To learn more: https://lnkd.in/dCFcWc3Z

#neuroskyence community: If you're working with touchscreen operant systems, touchscreencognition.org is a fantastic resource to check out.

You'll find SOPs, training videos, real data examples, forums, and more. And best of all, you can stay updated and connected with the touchscreen community 🧪

Visit TouchScreenCognition.org

Explore @touchscreencog.bsky.social, a global hub for touchscreen users, researchers & enthusiasts!

🔹 Training Videos
🔹 SOPs
🔹 Webinars
🔹 Discussion Forums

Refine your research, stay updated, & join the community!
TouchScreenCognition.org

#BehavioralResearch #TouchscreenTech #Science

If you are interested in great #fluorescencefriday videos, images and anything microscopy or
MRI related follow our new account for the MIND platform @mind-western.bsky.social @neuroak.bsky.social @touchscreencog.bsky.social @tridentpct.bsky.social

It is #fluorescencefriday and the MIND platform @touchscreencog.bsky.social @tridentpct.bsky.social invites you to see brain blood vessels stained with CD31 and imaged by lightsheet. 🐁 🧠 cleared with SHIELD . thanks as always to @shahrzadbahrampour.bsky.social @arashsalah.bsky.social and company.

The Unexpected Guardian of Early Life

A blog by Marilene Lopes explaining our latest fidings on STIP1 in early development communities.springernature.com/posts/the-un...

A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by abnormal accumulation of the RNA-binding protein TDP-43. Using a mouse model that mildly overexpresses human ...

Latest paper is Vlad Novikov’s careful analysis of proteostasis in a TDP-43 mouse model
A Longitudinal Study of Sex Differences in a TDP‐43 Mouse Model Reveals STI1 Regulation of TDP‐43 Proteinopathy and Motor Deficits - Journal of Neurochemistry - onlinelibrary.wiley.com/doi/10.1111/...

The Dangerous Precedent of Political Interference in Medical Research in Canada The European Animal Research Association (EARA) expresses deep concern over recent statements by Ontario Premier Doug Ford regarding biomedical research involving dogs.

Ontario’s message to the international world of biotech, medical devices and pharma…we don’t want your money or research partnerships.

Congratulations 🎉 🥳 to @kateonuska.bsky.social for successfully defending her PhD (co-supervised with Taylor Schmitz). No edits so she can rest for few days. Keep an eye out for Kate as she is one of a kind.

Our new interest: blood vessels and amyloid plaque interactions after lecanemab treatment of an ApoE4 AD mouse line #fluorescenceFriday @arashsalah.bsky.social and @shahrzadbahrampour.bsky.social for credits

a second rendering for #fluorescencefriday

Thanks to everyone who took the time to visit our booth at #AAIC25! We had a wonderful time and met some amazing people being part of the CIHR Institute of Aging's Canadian Pavilion. Until next year!

Last day of #AAIC25 for the exhibitors! Energy is still high 😎 come by our booth at the Canadian 🇨🇦 Pavilion

@touchscreencog.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @maximoprado.bsky.social @pradobsky.bsky.social

Great to have all our leaders out supporting the team and young talent at #AAIC25! Shout out to @lisasaksida.bsky.social, @timbussey.bsky.social, @maximoprado.bsky.social, and Vania Prado.

So much talent from @westernu.ca presenting their cognition and Alzheimer's research at #AAIC25! We are very proud of all of their hard work. Read full abstracts here: touchscreencognition.org/aaic-2025/

Campden Bussey-Saksida Touchscreen Chambers

Touchscreen-based assessments are transforming our understanding of brain regulation in complex behaviors. Piantadosi et al. (2025) published a guide about experimental design and essential hardware modifications for specialized research.

Check it out:
www.nature.com/articles/s41...

Check out our posters on Tuesday #AAIC. Learn about new mouse models in which we replaced mouse alpha synuclein with human gene, touchscreen testing in AD mice and ApoE4.

If you are interested in learning the limitations of current models of alpha synuclein pathology and why we need new KI humanized mouse models check out Latiyah’s poster
#AAIC25 Poster 200
Characterization of mouse of Synucleinopathies

@tridentpct.bsky.social @touchscreencog.bsky.social

Characterization of a novel transgenic mouse model to investigate brain-wide activation of astrocyte Gq signaling - Lab Animal This study uses a transgenic mouse line expressing Cre-inducible astro-hM3Dq to study astrocytes’ role in neuroinflammation and cognition without the use of viral transduction, mitigating the potentia...

Hot off the press Huge congrats to Alycia Crook a PhD student from the lab www.nature.com/articles/s41...

the MouseTRAP team will be presenting the following posters at #AAIC25 today. Come
say high and learn how we are using translational approaches to better understand proteinopathies. @touchscreencog.bsky.social @tridentpct.bsky.social

Get some swag plus strawberry milkshake at our booths in the Canadian Pavillion @touchscreencog.bsky.social @tridentpct.bsky.social and learn more about translational approaches to cognition, how well 🐁 can perform in touchscreen tasks #AAIC25

Hey #AAIC25 check out Arash’s presentation today at 8 AM and see some cool whole brain videos of the vasculaturs and plaques plus touchscreen testing

room 106

Evaluating the Efficacy and Risks of Early Lecanemab Treatment in APOE4 Humanized Alzheimer’s Disease Mouse Models

also poster 151

If you you interested in translational research #AAIC25 and improved rigour in cognitive testing check out the 🐁 2 🧍 approaches to test cognition in identical ways in mice and humans. @touchscreencog.bsky.social get some swag at the Canadian Pavilion.

The MouseTRAP team @touchscreencog.bsky.social @tridentpct.bsky.social presentations at #AAIC25

If you are interested in translating results from basic to clinical research come for a chat.

Why does TRIDENT have strawberry milkshakes at its booth at #AAIC2025 ? Listen to Sarah explain the scientific reasons.

Look at this world-class crew! 😍 So excited to see resident TRIDENT experts @maximoprado.bsky.social and Dr. Vania Prado stop by and say hi! #AAIC25 #NFRF

come by @tridentpct.bsky.social and @touchscreencog.bsky.social #AAIC25 and get your free strawberry milkshake (just the ones out mice get when they do their touchscreen tasks). Learn about touchscreen testing in mice and humans and the TRIDENT pipeline.

Great 1st day at #AAIC25! We're here for the rest of the week, stop by our @touchscreencog.bsky.social booth that's located in the Canadian Pavilion. 🎉

@maximoprado.bsky.social @westernubrainscan.bsky.social @lisasaksida.bsky.social @timbussey.bsky.social @tcnlab.bsky.social @pradobsky.bsky.social