Claudia Mimoso

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development Yim et al. use single-cell transcriptomics to elucidate the molecular outcomes of Chd8 haploinsufficiency in the mouse cortex. Their results provide insight into dynamic, cell-type-biased transcriptio...

Out in Cell Genomics: A comprehensive analysis of the cell-type-specific effects of CHD8 loss of function on gene expression in the embryonic and juvenile mouse cortex. Thread 🧵:
www.cell.com/cell-genomic...

Molecular basis of polyadenylated RNA fate determination in the nucleus Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

📣 Our department is hiring an Assistant Professor in Evolutionary Cell and Molecular Biology to join the @weillinstitute.bsky.social PLS spread the word!
academicjobsonline.org/ajo/jobs/30607

Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus!
Deadline is October 1st
danish-rna-society.nemtilmeld.dk/8/

Congrats Hanneke!! 🥳🥳

PhD position in Gene Regulation Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...

Thrilled to be one of the ERC StG awardees this year! It will allow my team to further delve into the puzzle of what regulates the fate of RNA Polymerase II during early elongation: will it terminate early, or elongate happily ever after?

[cite_start]A screenshot of the first page of a court document from the United States District Court for the District of Massachusetts[cite: 3]. [cite_start]The document is titled "MEMORANDUM AND ORDER" [cite: 43] [cite_start]and was filed on September 3, 2025[cite: 1]. The document lists two related civil actions: * [cite_start]**Civil Action No. 25-cv-11048-ADB**: President and Fellows of Harvard College, et al., Plaintiffs, v. United States Department of Health and Human Services, et al., Defendants[cite: 4, 5, 14, 17, 21]. * [cite_start]**Civil Action No. 25-cv-10910-ADB**: American Association of University Professors - Harvard Chapter, et al., Plaintiffs, v. United States Department of Justice, et al., Defendants[cite: 22, 23, 24, 26, 27, 36]. [cite_start]The order is from Judge Burroughs, D.J.[cite: 44]. [cite_start]The text begins by identifying the plaintiffs in the consolidated cases[cite: 45].

A screenshot of pages 81 and 82 from a court order, detailing the judge's rulings and the relief granted. **Rulings:** * **For Harvard's case:** The court grants Harvard's motion for summary judgment on several counts, including violations of the First Amendment and Title VI. It grants in part Harvard's motion regarding the "Freeze Orders" and grants in part the defendants' motion regarding the "Termination Letters," citing a lack of jurisdiction. * **For the Organizational Plaintiffs' case:** The court grants the plaintiffs' motion for summary judgment on their First Amendment claims and denies the defendants' cross-motion on several counts. The ruling on the "Freeze Orders" and "Termination Letters" mirrors the one in Harvard's case. **Ordered Relief:** 1. The court vacates and sets aside the Freeze Orders as arbitrary and capricious. 2. The court vacates and sets aside the Freeze Orders and Termination Letters as violations of the First Amendment. 3. The court vacates and sets aside the Termination Letters as violations of Title VI. 4. The court permanently enjoins the defendants from implementing the Freeze Orders, Termination Letters, and their unconstitutional conditions.

JUST IN: Harvard won summary judgment against the Trump administration with the court finding that the admin violated Harvard's 1st amend. rights. The court has vacated the funding freeze orders and termination letters and issued a permanent injunction.

storage.courtlistener.com/recap/gov.us...

Harvard Secures a Court Victory in Its Fight With Trump

Gift link.

Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Harvard’s research is shrinking amid the Trump administration’s freeze Even if grants at Harvard are suddenly restored, there is deep-rooted uncertainty about the damage already done and the future of basic science research in the U.S.

shocking to read over and over the stories of close colleagues who can't run their lab anymore. I know Karen well and it's heartbreaking. Also #PIinthelab! www.washingtonpost.com/education/20...

NIH: After review, we note that you have a large unspent balance on your grant. Please explain immediately.

me: well, uh, yeah, one reason we're not spending on that grant is because NIH terminated it in May along with all the rest of federal funding to Harvard, maybe you don't remember

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

PhD position in Gene Regulation Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.

Congrats Juan!!

🧑‍🔬I am thrilled to share I am starting my lab as an asst. prof. in the Dept. of Molecular and Cellular Biosciences at the University of Cincinnati. 🔬We will be hiring soon, so if you're interested in Mechanisms of Transcription Termination, watch this space 👀 🥳
www.clarehall.cam.ac.uk/news/dr-juan...

📢 Save the Date!
The 13th Yale RNA Center Annual Retreat returns this fall:
🗓️ November 7, 2025

Join us for a full day of cutting-edge RNA science and community.

Stay tuned for details on speakers, sessions, and registration.

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link:
mbg.au.dk/en/news-and-...

There's just a few more days for RNA Society members to get your artistic entries in!! 🎨 🧁 Don't miss the chance at some nice cash prizes, sponsored by GenScript 🤩🤩🤩

CAKUT variants in PRPF8, DYRK2, and CEP78: implications for splicing and ciliogenesis Introduction: Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of chronic kidney disease in children and young adults. Although over 50 monogenic causes have been ide...

Happy to have contributed to work by the Hildebrant lab @bostonchildrens.bsky.social $ @harvardmed.bsky.social on de novo variants in the splicing factor PRPF8 found in CAKUT (congenital abnormalities of the kidney and urinary tract) patients

www.biorxiv.org/content/10.1...

Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!

We are seeking speakers for the upcoming academic year! Contact us if you are interested!
@cambiochem.bsky.social #CambridgeRNAClub #RNAClub @rnasociety.bsky.social

😂😂😂

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

Thanks Ben!!

NEW ISSUE ALERT!!!

Check out the new Outlook, Review and Research Papers online now at Genes & Development.

Click on the link for more:
➡️ genesdev.cshlp.org/content/curr...

Assistant Professor (Research), Gerald Bronfman Department of Oncology, Lady Davis Institute for Medical Research (C1-250514) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Please RT! The oncology department & McGill is hiring an Assistant professor for a lab to be located at Lady Davis Institute (where I am!). McGill and the Lady Davis are fantastic places to do research and Montreal is great city to live in.

mcgill.wd3.myworkdayjobs.com/en-US/McGill...

Image showing all ~$2 billion in grants terminated at Harvard, highlighting the many terminated grants that were focused on training and career development

This is an excellent article on the termination of all federal funding at Harvard.

This visualization shows all of the terminated programs that were supposed to train the next generation of scientists.

www.nytimes.com/interactive/...

Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?

Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬