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Leonhard Held

@heldleonhard.bsky.social

Professor of Biostatistics at University of Zurich, Director UZH Center for Reproducible Science and Master Biostats, Steering committee Swiss Reproducibility Network (SwissRN)

161 Followers  |  162 Following  |  12 Posts  |  Joined: 21.10.2024  |  2.1476

Latest posts by heldleonhard.bsky.social on Bluesky

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Our SwissRN Academy offers a free "Early Career ReviewerΒ Workshop" at the University of Bern. Early career researchers will gain valuable experience in scientific peer review.
Date: September 11, 2025 (10:00 - 16:00)
Registration: Register by August 25 via forms.office.com/e/V3QEAFbN84

30.07.2025 12:44 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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πŸ‡¨πŸ‡­πŸ‡ͺπŸ‡Ί Just Published in Royal Society Open Science!

A scoping review on metrics to quantify reproducibility:
royalsocietypublishing.org/doi/10.1098/...

Ever conducted a replication and pondered when/how to conclude if it was (un)successful?
We have just the paper for you (led by Rachel Heyard)! 1/14

21.07.2025 08:41 β€” πŸ‘ 46    πŸ” 18    πŸ’¬ 1    πŸ“Œ 2
Home | consort-spirit.org

πŸŽ‰ Big news for clinical research! SPIRIT2025 just dropped, adding an Open Science section & a new Item No. 6 on data sharing. This pushes transparency in trialsβ€”where & how de-identified data, code, & materials will be accessible. Check it: www.consort-spirit.org #OpenScience #ClinicalTrials

19.05.2025 14:58 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 2    πŸ“Œ 1

Perplexing!

14.05.2025 19:21 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Plenty of tortured phrases (arxiv.org/abs/2107.0...) in this #IEEE paper. ieeexplore.ieee.org/...

My pubpeer report: pubpeer.com/publicat...

12.05.2025 05:30 β€” πŸ‘ 3    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1
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When Should Data and Code be Made Available? Abstract. Sharing data and code as part of a research publication is crucial for ensuring the computational reproducibility of scientific work. But sharing

Fully agree! But it is also very important that the code and data are shared at the review stage, so that referees can reproduce the results and see what is actually happening. Otherwise we have the "inverse problem" discussed here
academic.oup.com/jrssig/artic...

12.05.2025 11:22 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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UHaveIntegrity: A Strengths-Based Approach to Academic Integrity at the University of Calgary The #UHaveIntegrity campaign at the University of Calgary reframes academic integrity by focusing on students’ existing ethical foundations rather than viewing them as potential cheaters. It …

UHaveIntegrity: A Strengths-Based Approach to Academic Integrity at the University of Calgary buff.ly/yRXDrNS

11.05.2025 00:34 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
crossref webinar

crossref webinar

Transparency in research takes another step forward.

Join our April 2, 2025 webinar to explore Retraction Watch data in Crossref. Find out how it works and why it matters.

Register: https://tinyurl.com/tbf8w6u7

#Crossref #publishing #research

25.03.2025 16:11 β€” πŸ‘ 22    πŸ” 11    πŸ’¬ 0    πŸ“Œ 0

Hey there! We are ReproducibiliTea GenevaπŸ‘‹
As part of the @reproducibilitea.org community, we meet regularly at the University of Geneva to discuss all things open and reproducible science, in a relaxed atmosphere over a cup of teaπŸ«–πŸ“š! Feel free to get in touch!

18.03.2025 16:20 β€” πŸ‘ 9    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
Figure 2B from the paper in question, showing several Western blot panels (they look like light grey rectangles, some of which have a fat or thinner black horizontal stripe in the middle). I have marked some of these rectangles with boxes of the same color, highlighting those that look unexpectedly similar.

Figure 2B from the paper in question, showing several Western blot panels (they look like light grey rectangles, some of which have a fat or thinner black horizontal stripe in the middle). I have marked some of these rectangles with boxes of the same color, highlighting those that look unexpectedly similar.

Figure panels from Figure S2, from the supplemental. On the left a blot or gel, showing dark background with white bands. On the right a more classical western blots showing light grey background with dark grey horizontal stripes. In both panels I have highlighted lanes that look remarkably similar, with colored boxes.

Figure panels from Figure S2, from the supplemental. On the left a blot or gel, showing dark background with white bands. On the right a more classical western blots showing light grey background with dark grey horizontal stripes. In both panels I have highlighted lanes that look remarkably similar, with colored boxes.

Retraction @plosone.org - paper with authors from Ghent University.
"All authors either did not respond directly or could not be reached."
Does any journalist in Belgium want to write about this? It's so strange that none of the authors responded.
pubpeer.com/publications...

13.03.2025 20:39 β€” πŸ‘ 46    πŸ” 8    πŸ’¬ 3    πŸ“Œ 0
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Scientists Take on Scholarly Journals With Walkouts, Scathing Letters and Delistings Some scientists say the for-profit industry’s fast growth makes it harder to police fraud and low-quality work.

🚨Huge issue!

Needed: Quality > Quantity

Scientists see signs of trouble with quality at the biggest scientific journals www.wsj.com/business/med...

"Some of the work that has been published is so seriously flawed that it is not credible that it underwent any meaningful form of peer review."

13.03.2025 21:07 β€” πŸ‘ 50    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1

@evievergauwe.bsky.social @hannowuerbel.bsky.social

13.03.2025 19:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Truth and trust are pillars for research Horizons - Issue 144

Very pleased to see #reproducibility #transparency #integrity #openscience emphasized to ensure trust in science in Switzerland and beyond

All part of the @swissrn.bsky.social strategy:
www.swissrn.org/contents/com...

Truth and trust are pillars for research www.horizons-mag.ch/2025/03/06/t...

13.03.2025 19:27 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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2024 Einstein Foundation Award Winners Colloquium YouTube video by Einstein Foundation Berlin

πŸ•“Today at 4pm (CET): Join the 2024 #EinsteinFoundationAward winners' colloquium on scientific integrity with @elisabethbik.bsky.social, @brandonstell.bsky.social from @pubpeer.com, and @helenajambor.bsky.social and Christopher Schmied from PixelQuality via Livestream: www.youtube.com/live/ZZ5R8CG...

13.03.2025 11:19 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 0    πŸ“Œ 2

thanks for the reminder. I just deactivated my Twitter account.

13.03.2025 11:09 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Sometimes it would help if English speaking academics understand German. E.g. Liebermeister's Bayesian analysis of the 2x2 table from 1877

www.jameslindlibrary.org/articles/par...

was reinvented by William Thompson (1933, Biometrika) and Patricia Altham (1969, JRSSB)

10.03.2025 11:56 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Highly recommended!

10.03.2025 07:43 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Welcome to Zurich, Tobias! Looking forward to interact on Open and Reproducible Science

27.02.2025 17:10 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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A comparison of combined p-value functions for meta-analysis P-value functions are modern statistical tools that unify effect estimation and hypothesis testing and can provide alternative point and interval estimates compared to standard meta-analysis methods, ...

Tired of fixed effect and random-effects meta-analysis?
Check out our revised manuscript on p-value combination methods for meta-analysis:
arxiv.org/abs/2408.08135

25.02.2025 22:25 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Beyond the two‐trials rule The two-trials rule for drug approval requires β€œat least two adequate and well-controlled studies, each convincing on its own, to establish effectiveness.” This is usually implemented by requiring tw...

Thanks Judith! Here is the link:

doi.org/10.1002/sim....

25.02.2025 22:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Plain English with Derek Thompson - Fraud, Scandal, and Failure in the Fight Against Alzheimer's Disease Listen to Plain English with Derek Thompson - Fraud, Scandal, and Failure in the Fight Against Alzheimer's Disease by The Ringer on Podcast Addict. Why is it so hard to find a cure for Alzheimer’s? A simple answer is that the brain and its disorders are complicated. But as today’s guest, Charles Piller, writes, there’s another, more sinister factor at play. His new book, 'Doctored,' traces an incredible, true story of fraud, arrogance, and tragedy in the quest to cure Alzheimer’s.In the last few years, some of the most

"The most expensive, most widespread example of catastrophic research fraud in the history of modern science?"
Listen to this, "if you love science and you want to see science done well".
podcastaddict.com/plain-englis...

17.02.2025 11:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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ICYMI: Second paper by Nobel laureate Thomas SΓΌdhof retracted Thomas SΓΌdhof A 2017 paper coauthored by Nobel laureate Thomas SΓΌdhof has been retracted.Β  The article, β€œConditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer…

ICYMI: Second paper by Nobel laureate Thomas SΓΌdhof retracted

@retractionwatch.com

retractionwatch.com/2025/02/14/i...

15.02.2025 07:03 β€” πŸ‘ 89    πŸ” 22    πŸ’¬ 2    πŸ“Œ 0

The Swiss Reproducibility Network (SwissRN) is now on Bluesky! Make sure to follow
@swissrn.bsky.social

14.02.2025 17:40 β€” πŸ‘ 4    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
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UKRN welcomes eLife and Hidden REF as new stakeholders | UK Reproducibility Network Feb 4, 2025 | News

We’re pleased to join the UK Reproducibility Network (@ukrepro.bsky.social) as a stakeholder in support of a more open, transparent and reproducible research culture. Find out more:

04.02.2025 17:45 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Are @zbmed.bsky.social aware of the negative reaction on social media to their just-announced contract with MDPI. There's a great many red flags they seem to have missed, e.g.
deevybee.blogspot.com/2024/08/gues...
deevybee.blogspot.com/2024/02/the-...
+ @hansonmark@bsky.social's account below

21.12.2024 13:20 β€” πŸ‘ 80    πŸ” 27    πŸ’¬ 2    πŸ“Œ 3
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Why probability probably doesn’t exist (but it is useful to act like it does) All of statistics and much of science depends on probability β€” an astonishing achievement, considering no one’s really sure what it is.

Why probability probably doesn’t exist (but it is useful to act like it does) - by D. Spiegelhalter

www.nature.com/articles/d41...

A great article highlighting the subjective nature of uncertainty, particularly relevant to our thinking about the nature of anxiety.

20.12.2024 11:19 β€” πŸ‘ 35    πŸ” 11    πŸ’¬ 3    πŸ“Œ 2
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Changes to the classification

Big news from Finnish publication forum. Almost all MDPI and Frontiers journals will be downgraded to level 0 and thus are not considered as properly peer reviewed trustworthy scientific journals.
julkaisufoorumi.fi/en/news/chan...

16.12.2024 10:12 β€” πŸ‘ 406    πŸ” 280    πŸ’¬ 18    πŸ“Œ 46
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ICYMI from earlier in 2024:

Reporting on data sharing: executive position of the EQUATOR Network published in the @bmj.com

www.bmj.com/content/386/...

#transparency #researchintegrity #datasharing #openscience #codesharing #reproducibility #metascience

13.12.2024 09:07 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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How a simple math error sparked a panic about black plastic kitchen utensils A study warned that people were being exposed to a toxic chemical from kitchen utensils. But the researchers misstated the safe daily limit

"But 60 times 7,000 is not 42,000. It is 420,000."

whoops!

nationalpost.com/news/canada/...

13.12.2024 04:14 β€” πŸ‘ 44    πŸ” 9    πŸ’¬ 2    πŸ“Œ 8
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OBGYN Click on the article title to read more.

Another day, another retraction. I complained about this article to the journal in June 2023 - I've been told the first time the editors were notified about it was way back in 2021:

obgyn.onlinelibrary.wiley.com/doi/10.1002/...

01.12.2024 20:59 β€” πŸ‘ 27    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0

@heldleonhard is following 19 prominent accounts