Mike Schumacher

Home 2026 Join colleagues across the entire spectrum of clinical care and science at the premier conference on inflammatory bowel disease (IBD).

Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N
#IBDsky #GIsky #Gastrosky

#Bcells are emerging as key players in #IBD, far beyond a T-cell story.

From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.

Check Fran and Bianca's review 👇

doi.org/10.1016/j.im...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Giggling her way into 3 months old

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

ulcerative colitis tissue section

Immune cell stratification in the inflamed intestinal epithelium

#immunofluorescence #microscopy #ibd

Review the contributions of mucus-associated microbes who are “Living on the Edge” in the colon:
www.mucosalimmunology.org/article/S193...

A baby surrounded by medical devices is being held up by someone with gloved hands. A headline reads: "Baby Is Healed With World's First Personalized Gene-Editing Treatment." Photo courtesy of Children's Hospital of Pennsylvania.

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

Household mischief level about to double, welcome home baby two 🙃

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: The path to a new pain medication with little potential for addiction

Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.

Rare genetic disorder treated in womb for the first time The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”

I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...

Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Understanding the therapeutic toolkit for inflammatory bowel disease Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…

New online! Understanding the therapeutic toolkit for inflammatory bowel disease

New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Axolotl epidermis pseudo-colored for depth and artistic interpretation :-) Cell membranes and chromatin marked by fluorescent protein fusions

A little confocal time in the empty lab is the New Year's start that I needed!

Immune phenotyping of the colon in IBD
#immunofluorescence #microscopy

Biologic agents for IBD come of age as host–microbe interactions emerge - Nature Reviews Gastroenterology & Hepatology In 2024, there were major advances in inflammatory bowel disease research. Treatment strategies with biologic agents for inflammatory bowel disease matured, and gut microbiota–bacteriophage–host inter...

NEW Year-in-Review in #NatureReviewsGastroHep highlighting the key papers in #IBD in 2024

Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...

#IBDsky #GastroSky #Microsky 🧪

Z-stacking thru a goblet cell stained enteroid #immunofluorescence #microscopy

Thanks! I will look up your work. Apart from cancer-sourced il33 have you been able to identify epithelial patterns of Il33 in left v right?

Thanks for pointing out your findings! Our prior working hypothesis on SI was that il33 cells may co-localize w Clu or Ly6a in our inflammation model, but if similar to the Helminth model, that may not necessarily be the case

Thanks Irah!

Links are hard, here is the corrected link to the paper: www.mucosalimmunology.org/article/S193...

Thanks to all wonderful co-authors on 🦋 @squeakyanimal.bsky.social Insightful reviewers, @mucosalimmunol.bsky.social @societymucosalimm.bsky.social and support from NIDDK, Children’s Hospital LA, @ibdpro.bsky.social /8

Looking forward to developing work on immunoregulatory roles of the ISC niche!