Pat Eyers

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That's 3 national championships in a row for @harvard.edu women's rugby.

RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...

I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...

Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation. Induced protein proximity offers powerful new routes to modulate protein fate. While proteolysis-targeting chimeras (PROTACs) promote degradation through E3 ligase recruitment, the converse principle-...

Our latest preprint is out!
We developed an inducible “RapTag” system that uses ENTAC to chemically recruit USP15 to the unstable protein CTLA4. This induced proximity stabilises and slows down the rapid lysosomal turnover of CTLA4.
@livuni-ismib.bsky.social
www.biorxiv.org/content/10.1...

Very much worth a read. The Lords know what is needed to drive translational research. The Govt?
publications.parliament.uk/pa/ld5901/ld...

Together with @pseudoenzyme.bsky.social I had a wonderful and very inspiring day at the Dyrk1a Syndrome Community Family Conference on Saturday. Wonderful families and wonderful support from volunteers at the Barnstondale Centre in the Wirral. Thank you for the warm welcome

We’re celebrating a global rise! 🎓

The University of Liverpool is now ranked 147th in the world in the QS World University Rankings 2026 — officially in the Top 150!

#TeamLivUni💙

Read more ⬇️

news.liverpool.ac.uk/2025/06/19/u...

NEWS I We will open a campus in Bengaluru, India, building on our strong existing collaborations in the region. In Delhi today, the Indian Minister of Education formally awarded our VC a Letter of Intent giving official permission for the campus 🇬🇧 🇮🇳

Read more: news.liverpool.ac.uk/2025/05/26/u...

Fantastic to be at the @royalsociety.org today celebrating progress and initiatives to support the technician community. @uk-itss.bsky.social @livunihls.bsky.social

I think you should probably say no to this, TBH

Naga. That is all.

An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases The bacterial serine-threonine kinome is a resource for functional studies and drug development.

An atlas of bacterial serine-threonine kinases reveals functional diversity and key distinctions from eukaryotic kinases | Science Signaling www.science.org/doi/10.1126/...

A group of 8 people gathered together outside with a backdrop of the Babraham Research Campus. From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.

What's the collective noun for @biochemsoc.bsky.social Morton Prize winners? We gathered together as many as we could get our hands on, including newest recipient Len.

From left to right: Phill Hawkins, Peter Cullen, Robin Irvine, Peter Parker, Roger Williams, Len Stephens and Bob Mitchell.

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...

I'm am very excited - and little bit emotional - today as we start the two day Symposium to celebrate the achievements and retirement of my colleagues and chief PI3K gurus - Len Stephens and Phill Hawkins

A big day for @biochemsoc.bsky.social 2026 Morton Lecture awardee Dr Len Stepehns, introduced by @drsimoncook.bsky.social @babrahaminst.bsky.social

Agreed. What's the allotment looking like?

Final week for the early bird deadline for the Small G-protein meeting in Manchester. Talk slots available from submitted abstracts. #SGP25 @BiochemSoc @SmallGTPases Register here: bit.ly/SmallG25

A Biochemical Society Scientific Meeting Small G proteins in cellular signalling and disease 2025 24-27 June 2025 Manchester, UK Abstract and earlybird deadline 24 April 2025

Don't miss out! The earlybird discount and abstract submission deadline for our upcoming small G protein conference is this Thursday 24 April! Submit your abstract for consideration and register now to save £50! #SGP25 🧪
www.eventsforce.net/biochemsoc/2...

Really looking forward to this meeting!

A dapper Vinnie Tagliabracci picking up an @asbmb.bsky.social Early Career Scolar Award in between social engagements

Remembering David Stephens (1971–2024) In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...

journals.biologists.com/jcs/article/...

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

www.nature.com/articles/s41...

Science fans of Liverpool - check out @liverpooluni.bsky.social Pint of Science nights and grab your tickets here pintofscience.co.uk/organisation... 🍻

@livunihls.bsky.social @livuniresearch.bsky.social @livuninews.bsky.social

Move along.

Image of three covers of Journal of Cell Science

Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...

Pleased to be in Chicago. Part-science, part to support all our US colleagues @biochemsoc.bsky.social @asbmb.bsky.social

RNA Motifs Coming Into Focus

Exciting future for Structural RNA

www.science.org/content/blog...

A collage of the 17 2026 Biochemical Society Award winners

We are so proud of all our Biochemical Society 2026 Award winners. Visit our website to find out more about all of the deserving recipients 🧪 #BiochemAwards
ow.ly/bGbY50VwkYF