Jesse Raab

Ectopic H3K36me2 can be targeted in cancer with potent small molecules that inhibit NSD2. Work from Or Gozani and collaborators.

In my small corner of biology, I’m constantly reassured by how frequently we confirm main findings. And then when differences do show up, they very rarely end up being fraud, but instead tell us something important about differences in experimental design.

Improving Oversight of Federal Grantmaking By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years.

Today's executive order includes a provision that will obliterate both functions.

Just trying to make the chapel hill to obx ferry a reality indyweek.com/culture/scre...

In Apex, flood damage means months of delays, millions in repairs On Olive Chapel Rd in Apex, the street collapsed under the weight of rushing water, opening a sinkhole that could take months and millions to fix. According to state Department of Transportation, the ...

Olive chapel road in Apex washed out pretty badly www.wral.com/weather/heav...

Chromatin-dependent motif syntax defines differentiation trajectories

www.cell.com/molecular-ce...

PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social

www.nature.com/articles/s41...

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Differential regulation of eye specification in Drosophila by Polycomb Group epigenetic repressors Highlighted Article: Distinct gene sets are differentially expressed in response to the knockdown of Polycomb Group (PcG) members, suggesting that multiple avenues may exist for the eye to be transfor...

My lab's newest research paper on the Drosophila eye is published in Development today. Thanks to the editorial staff for writing a research highlight and interviewing us about our work.

journals.biologists.com/dev/article-...

The rest of the world, fortunately, will not ignore the huge potential of RNA vaccines. The result will be loss of leadership in the US and delay of benefits to Americans. The promise of personalized anti-cancer vaccines alone is incredible. #OwnGoal

1/ They call us “bioinformagicians.” But we’re not magicians.
We can’t save an experiment that was broken before it began.
Here’s why. 🧵

Quote for a 63x objective. The objective is $12,784. The tariff is $1,661.92

Zeiss 63x objective

We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany

Got mine yesterday, no NOA for the supplement I had attached to it

NIH 2025 allocation was (supposed to be) $48 billion with a B.

The proposed $400 million with an M is a 0.8% increase...

...which amounts to an inflation-adjusted cut.

And yet many of us are "happy" now?

They're just turning up the heat on the frog pot with this.

ACLY inhibition promotes tumour immunity and suppresses liver cancer - Nature Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

www.nature.com/articles/s41...

Congratulations to this new generation of leading cancer scientists, and to the message they’re sending, with 50% of the awardees placing epigenetics at the heart of their research. The future is speaking. The path forward is both bright and bold.

Again, the whole purpose of this madness has, from day 1, been to destroy the US leadership in science, technology, and innovation.

This is just one more way to ensure that goal is achieved.

“But why?” you might, rightly, ask. To which I say, pick up a history book and you’ll have your answer.

Given the lack of significant outrage, people are either unaware or believe they can weather this storm. The latter set reminds me of folks confident they would get on the lifeboats when the Titanic was sinking. At 5% success & a six-grant application limit, there aren't enough lifeboats. /2

The NIH was healthiest when pay lines were in the 20th percentile range.

We are headed into an environment where pay lines are in the 5% range.

In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one.

This is going to destroy science.

Coordinated expression of retained introns and poison exons in renal cell carcinoma Martínez et al. identify a set of ccRCC tumors with high levels of intron retention (IR) and poison exon (PE) inclusion, producing transcripts normally targeted by the NMD pathway. These tumors have altered mTOR signaling, are associated with poor prognosis, and have unique signatures of immune cell infiltration.

Coordinated expression of retained introns and poison exons in renal cell carcinoma

This is the same amount as the entire National Science Foundation's R&D spending for the entire field of *engineering* for the whole country. All of it.

Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @cp-cell.bsky.social, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. www.sciencedirect.com/science/arti...

Could AI slow science? Confronting the production-progress paradox

This is a pretty interesting post - Could AI slow science? www.aisnakeoil.com/p/could-ai-s...

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.

If you wanna check in on the nation's cancer researchers, we're doin' bad. Real bad. No single post/article fully captures the depth and breadth of it.
We may be the first to feel this, but every single person in the country will feel it eventually.
Cancer. Does. Not. Discriminate.

Consequences will not be felt today, but 5 year, 10 years down the road, when you're diagnosed with cancer, and you need a new clinical trial to hop onto, or a new drug to let you watch your grandkids grow up, they won't exist. Why would anyone choose to side with cancer against humanity? 🧪

National Cancer Institute projection of a 4% pay line in FY2026.

Good grief, the US National Cancer Institute projects it will fund only one in 25 RO1 grant applications in 2026. This is massively defunding cancer research. Despicable vandalism. www.cancer.gov/grants-train...

In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.