Jesse Raab

UNC Sends Delegation for Capitol Event | Biochemistry and Biophysics Rally for Medical Research – September 18, 2025 | Washington, DC A delegation from UNC joined more than 400 advocates from across the country in Washington DC to urge Congress to prioritize funding fo...

UNC Sends Delegation for Capitol Event
Rally for Medical Research – September 18, 2025 Washington, DC
www.med.unc.edu/biochem/news...

Buffalo peeps! I am hosting a science spooktacular event at the new Third Space venue downtown on Oct 30 at 6PM! Come hear fun stories about science from trainees, all geared towards a non-specialist audience. Check the flyer for all the info! Please RT

YouTube video by Black In Biophys BIBPSSpotlight - 2025 Black In Biophysics Week

We are in this odd climate where people are pretending no barriers exist to careers in science for some groups, but this conversation with 2 outstanding emerging scientists highlights that is just not true.
youtube.com/watch?v=u850...

Picture of Eric

Picture of Rob

Amazing science continues to happen in the US, and we continue to hire remarkable new faculty. Already this term UNC Biology has had terrific promotion seminars from two rising stars: Eric Riddell and Rob Dowen. 1/n

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Great department and job opportunity

Hey remember when the CDC dropped 6 of the 8 foodborne illnesses from the nationwide monitoring system in July and one of them was listeria? Mentioning for no particular reason www.nbcnews.com/health/healt...

I think the same thing while I fill out my 800th conflict of interest declaration for submitting a grant

A grant showing the number of projects funded for FY2021 through FY2025. The number for FY2025 lagged behind and did not catch up with 4014 fewer projects funded in FY2025 compared with FY2024.

Here are the results in terms of the number of projects.

The number of funded projects in FY2025 is 4014 fewer than the number for FY2024.

2/3

I believe so

seems like first pass literature surfacing is a good use case - still pretty hit or miss though. I have claude pro but maybe I'll try the chatgpt pro/deep for a month. consensus.ai and futurehouse both seem potentially useful but I'm not sure they're any better than chatgpt/claude at the moment

I had this happen once asking about organoids I think, but only with one model. If I switched (sonnet to opus maybe?) It went through, was pretty strange.

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that could transform lives, tearful doctors tell BBC

Wonderful news. A salutary reminder of the absolute benefits of scientific progress, and the absolute evil of conspiracist bollocks.

Huntington's disease successfully treated for first time www.bbc.com/news/article...

Epigenetic relay: Polycomb-directed DNA methylation in mammalian development In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...

Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...

#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...

esBAF and INO80C fine-tune subcompartments and differentially regulate enhancer-promoter interactions The genome is compacted in the nucleus through a hierarchical chromatin organization, ranging from chromosome territories to compartments, topologically associating domains (TADs), and individual nucl...

New preprint is up, led by former postdoc Braulio Bonilla.
We know these remodelers regulate nucleosome positions and occupancy, but do they have a role in regulating higher order chromatin structure? We take a peek for BAF and INO80C.
www.biorxiv.org/content/10.1...

By creating an Account with Academia.edu, you grant us a worldwide, irrevocable, non-exclusive, transferable license, permission, and consent for Academia.edu to use your Member Content and your personal information (including, but not limited to, your name, voice, signature, photograph, likeness, city, institutional affiliations, citations, mentions, publications, and areas of interest) in any manner, including for the purpose of advertising, selling, or soliciting the use or purchase of Academia.edu's Services.

I'm sorry, worldwide, irrevocable, non-exclusive, transferable permission to my voice and likeness? For what now? In any manner for any purpose???

This is in academia/.edu's new ToS, which you're prompted to agree to on login. Anyway I'll be jumping ship. You can find my stuff at hcommons.org.

obviously attack - the talk title puns write themselves

Co-targeting the PI3K-Akt pathway improves response to MEK inhibition in low-grade serous ovarian cancer cell lines https://www.biorxiv.org/content/10.1101/2025.09.05.674550v1

Listening to Shelley Earp reflect on his overall experience as a scientist following several Nobel Laureates and inspiring scientists speak about how he impacted their career.

I don’t care about accolades: this is the type of legacy I aspire to have, to have uplifted so many 🤩🪜

A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy Gao and colleagues identify new therapeutic opportunities for pancreatic cancer via integrated pharmacogenomic analysis of organoid models, highlighting statins as effective agents to overcome chemore...

A #PancreaticCancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapy 🧪 www.cell.com/cell-stem-ce...

What are your pros/cons of using AI in science?

Feel free to respond wrt use or harm in the design of experiments, coding experiments, coding analysis, brain storming analysis, summarizing literature, synthesis of ideas, modeling, novel model development, mathematical proofs, writing, editing.

Fragile Nucleosome Fall Seminars: September 10 Grace Bower, Kvon Lab @ UC Irvine, USA Jennifer Phillips-Cremins, UPenn, USA September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA Juanma Schvartzman, Columbia University, USA October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA Alex Federation, Talus Bio, USA October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland Seungsoo Kim, UC Irvine, USA November 5 Hannah Long, University of Edinburgh, UK Jeff Vierstra, Altius Institute, USA November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada Sarah Teichmann, University of Cambridge, UK December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain Jonathan Henninger, Carnegie Mellon, USA December 17 Rebecca Berrens, Oxford University, UK Jean-Benoit Lalanne, University of Montreal, Canada

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.

Invisibility cloak pioneer Sir John Pendry awarded Royal Society’s top prize | Royal Society The Royal Society announces the medals and awards recipients 2025

Very honored to receive the Royal Society Research Culture Award - this represents the work of a great team who've worked non-stop since we launched bioRxiv in 2013 royalsociety.org/news/2025/08... www.cshl.edu/inglis-and-s...

This is awful

Triangle at the epicenter of proposed cuts to federal funding for medical research Congressional districts that include Durham, Orange and Wake counties stand to lose billions of dollars and thousands of jobs if proposed cuts to funding for the National Institutes of Health become a...

www.wral.com/story/triang...
Cuts to science funding are predictably leading to major job cuts in NC

but then how would they make 50% profit margin

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10....

@imperiallifesci.bsky.social

Articles like this make me somewhat bullish on the utility of this stuff for biology, but way more bearish that it's used correctly. The examples in here offloads dozens of decisions a biologist has to make when doing the experiment - with the goal of the biologist to know nothing of these decisions