Morwan Osman's Avatar

Morwan Osman

@morwan.me.bsky.social

Mycobacteriologist and Postdoctoral Fellow in the York Bioenergetics Lab, University Of York (@jnb-lab.bsky.social). Formerly: @pembroke1347.bsky.social & @mrclmb.bsky.social. @mcbseattle.bsky.social PhD.

507 Followers  |  311 Following  |  29 Posts  |  Joined: 09.06.2023  |  1.9756

Latest posts by morwan.me on Bluesky

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Call for applications: The BSAC Parliamentary Internship Programme 2025 - The British Society for Antimicrobial Chemotherapy

Applications close 10 August for our paid Parliamentary Internship Programme. If you're a UK-based PhD student passionate about #AMR and infectious disease policy, this is a unique chance to gain first-hand experience in UK Parliament. Find out more and apply: bsac.org.uk/call-for-app...

04.08.2025 10:42 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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UKRI award rate halves in seven years as grant applications double - Research Professional News Trends across research councils prompt warning that system is β€œoverstretched or broken”

Feels about right

www.researchprofessionalnews.com/rr-news-uk-r...

04.08.2025 06:41 β€” πŸ‘ 30    πŸ” 18    πŸ’¬ 4    πŸ“Œ 1

I don't think people need to sit around wringing their hands or scrolling. We can act and do the things we want.

03.08.2025 14:29 β€” πŸ‘ 199    πŸ” 41    πŸ’¬ 7    πŸ“Œ 0

Assessing cellular metabolic dynamics with NAD(P)H fluorescence polarization imaging https://www.biorxiv.org/content/10.1101/2025.07.28.667273v1

01.08.2025 03:50 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a pro...

This has a neat mechanism of inhibition:
www.nature.com/articles/s41...

30.07.2025 20:12 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
ASM Leads Letter on Federal Biosecurity & Biosafety Policy | ASM.org The American Society for Microbiology leads a stakeholder letter expressing concerns on the implementation of EO 14292.

Thanks for your leadership on this @asm.org. asm.org/articles/pol...

29.07.2025 21:55 β€” πŸ‘ 12    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
Research Associate - Microbial Metabolomic Research Associate - Microbial Metabolomic

*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec?

Come join the group! Informal enquires welcome!

Closing Date: 19 August 2025

jobs.ncl.ac.uk/job/Newcastl...

22.07.2025 14:32 β€” πŸ‘ 19    πŸ” 29    πŸ’¬ 0    πŸ“Œ 2
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ATP synthesis driven by atmospheric hydrogen concentrations | PNAS All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The un...

Our article showing energy production from air alone is in PNAS today. This paper provides an ultimate biochemical proof that microbes can survive simply by 'making' energy from air (making two ATP per molecule atmospheric H2 consumed) and has biotech applications. www.pnas.org/doi/10.1073/...

25.07.2025 00:54 β€” πŸ‘ 118    πŸ” 55    πŸ’¬ 4    πŸ“Œ 6
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A new protein-dependent riboswitch activates ribosomal frameshifting Programmed -1 ribosomal frameshifting (PRF) is a ubiquitous translational control mechanism in RNA viruses, allowing them to change the relative abundance of proteins encoded in different reading fram...

New preprint alert! πŸš¨πŸ‘‡ I'm delighted to share the latest research from @jemmabetts.bsky.social
in our group: β€˜A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨

www.biorxiv.org/content/10.1...

19.07.2025 15:10 β€” πŸ‘ 68    πŸ” 22    πŸ’¬ 2    πŸ“Œ 3
The Black in Micro Week 2025 schedule announcement with a black and yellow microbe background. The flyer reads "Black Microbiologists Association presents Black in Micro Week 2025, October 14-16. Events: Mon 14, Pathways for Change; Tues 15, Careers & Research; Weds 16, Community. The Conference theme is Harmony: Hope, Alliance, Resilience, Mutual Support, Optimism, Nurturing and Yielding Progress. Registration opens soon.

The Black in Micro Week 2025 schedule announcement with a black and yellow microbe background. The flyer reads "Black Microbiologists Association presents Black in Micro Week 2025, October 14-16. Events: Mon 14, Pathways for Change; Tues 15, Careers & Research; Weds 16, Community. The Conference theme is Harmony: Hope, Alliance, Resilience, Mutual Support, Optimism, Nurturing and Yielding Progress. Registration opens soon.

In a year filled with uncertainty for the future of science, we’re choosing to lead with HARMONY.πŸ’›πŸ§« We believe in the power of community, in raising our voices, and in caring deeply for one another. This October, join us as we create a space rooted in hope. #BlackInMicroWeek #BiM2025

10.06.2025 13:07 β€” πŸ‘ 10    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
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Rising Talent Fellowship - MRC Laboratory of Molecular Biology RISING TALENT FELLOWSHIP In 2024 the MRC Laboratory of Molecular Biology (LMB) launched the first round of their three-year fully funded fellowship for

I'll soon be recruiting a postdoc fellow to join us @mrclmb.bsky.social to continue developing our programme to understand neuroimmune modulationπŸ§ πŸ”¬πŸ§¬πŸ©ΈπŸ«
If you're interested in joining us check also @erc.europa.eu MSCA actions, @wellcometrust.bsky.social & www2.mrc-lmb.cam.ac.uk/recruitment/...
DM'me

09.07.2025 19:03 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
MitoTracker transfers from astrocytes to neurons independently of mitochondria The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...

08.07.2025 22:45 β€” πŸ‘ 27    πŸ” 16    πŸ’¬ 1    πŸ“Œ 2
A pin featuring a photo of a clownfish and the text "where the fuck is my son?"

A pin featuring a photo of a clownfish and the text "where the fuck is my son?"

Thank you, random Denver vending machine, for the greatest fucking pin I've ever seen.

06.07.2025 02:27 β€” πŸ‘ 2492    πŸ” 481    πŸ’¬ 14    πŸ“Œ 8
Bar chart titled "Matters of Scale" comparing proposed US research budget cuts to the European Union's €500-million (US$571-million) "Choose Europe" fund. The chart shows:

* National Institutes of Health (NIH): $8 billion in cancelled grants and $18 billion in proposed cuts by 2026 (long orange bar).
* National Science Foundation (NSF): $5.1 billion in proposed cuts by 2026 (shorter orange bar).
* EU's Choose Europe fund: $571 million (very short blue bar).

The graphic highlights that the EU fund is much smaller in scale compared to the US budget cuts. Text above the chart explains the EU’s intention to attract US researchers in response to policy decisions by the convicted felon and rapist Donald Trump.

Bar chart titled "Matters of Scale" comparing proposed US research budget cuts to the European Union's €500-million (US$571-million) "Choose Europe" fund. The chart shows: * National Institutes of Health (NIH): $8 billion in cancelled grants and $18 billion in proposed cuts by 2026 (long orange bar). * National Science Foundation (NSF): $5.1 billion in proposed cuts by 2026 (shorter orange bar). * EU's Choose Europe fund: $571 million (very short blue bar). The graphic highlights that the EU fund is much smaller in scale compared to the US budget cuts. Text above the chart explains the EU’s intention to attract US researchers in response to policy decisions by the convicted felon and rapist Donald Trump.

If people think American scientists are somehow going to land in Europe, I've got news for you about the difference between millions and billions.

www.nature.com/articles/d41...

04.07.2025 21:01 β€” πŸ‘ 1009    πŸ” 365    πŸ’¬ 50    πŸ“Œ 49

Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage https://www.biorxiv.org/content/10.1101/2025.07.04.663131v1

05.07.2025 03:17 β€” πŸ‘ 3    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

Real world example that humans are not mice - something we should always keep in mind when studying immunology in model systems. πŸ˜‰

04.07.2025 15:06 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

It's LIVE! #BSF25
I can now announce that I have created "Antiviral Skating" πŸ›ΌπŸ¦ βœ¨οΈ A collaboration with @livuni-ismib.bsky.social & Liverpool Roller Birds

Friday 12th September. 18.30 at @ Unity Theatre

FREE tickets πŸ‘‡πŸΎ
britishscienceassociation-tickets.ticketsolve.com/ticketbooth/...

04.07.2025 08:07 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Viral genomes track the transmission of mpox in humans before 2017 outbreak Genomic analysis shows that mpox emerged in humans in 2014 in southern Nigeria.

Delighted that our Research Briefing on our paper on the origins of the Clade IIb Mpox outbreak and the continued emergence risk in West Africa is out! www.nature.com/articles/d41...

03.07.2025 08:03 β€” πŸ‘ 12    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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πŸš¨πŸ“†β° ABSTRACT SUBMISSION REMINDER 🧬🦠🧫
The ECR symposium abstract call closes in less than ONE WEEK!
Submit your abstract at tinyurl.com/BIM-abst... by July 8, 11.59PM EST! #BiM2025 #BlackInMicrobiology #EarlyCareerResearch

02.07.2025 20:28 β€” πŸ‘ 2    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Guardian’s ed editor, Richard Adams, follows house style and does not mention the report’s author, Alice Sullivan, is one of the loudest anti-trans campaigners at a UK university.

Add this report to the pile of similar official reports, such as β€˜Racist Finds UK Not Institutionally Racist’,

02.07.2025 06:41 β€” πŸ‘ 895    πŸ” 237    πŸ’¬ 17    πŸ“Œ 7
Job Details

Come and work with us!

Senior Biostatistical Researcher bit.ly/4kRfZxI
Senior Bioinformatic Engineer bit.ly/4ecl0hF
both Grade 8 or 7, closing noon Tue 8 Jul

Computational Mycobacteriologist
Grade 7, closing noon Fri 4 Jul bit.ly/4ndKOhF

@medsci.ox.ac.uk
@oxfordbrc.bsky.social
@ndm.ox.ac.uk

01.07.2025 07:24 β€” πŸ‘ 3    πŸ” 7    πŸ’¬ 0    πŸ“Œ 1
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The Christine Mirzayan Science and Technology Policy Graduate Fellowship Program This program is an early career educational and training opportunity. It is designed to engage its Fellows in the analytical process that informs U.S. science and technology policy.

Any grad students interested in a career in science policy? Check out this opportunity: mirzayanfellow.nas.edu?utm_source=N...

30.06.2025 15:02 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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25 new scholarships for US researchers Fonds Zukunft Γ–sterreich (FZΓ–) is providing €10 million in funding for an academy program to bring postdocs from the USA to Austria ++ Faßmann: β€œThe right signal in these turbulent times”

Are you a #postdoc in the US looking to next steps?

The Austrian Academy of Sciences is opening up 25 fellowships: www.oeaw.ac.at/en/news/25-n...

A great reason to use our visitor program at #Complexity #Science Hub @csh.ac.at and see how you would fit in: csh.ac.at/engage/resea... πŸ§ͺπŸ¦‹

29.06.2025 12:00 β€” πŸ‘ 59    πŸ” 46    πŸ’¬ 2    πŸ“Œ 3
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A host organelle integrates stolen chloroplasts for animal photosynthesis Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.

Remarkable paper explaining how sea slugs maintain chloroplasts obtained by kleptoplasty active for many month & eventually digest them for resources www.cell.com/cell/fulltex...

26.06.2025 06:41 β€” πŸ‘ 84    πŸ” 32    πŸ’¬ 0    πŸ“Œ 5
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(6/8) Using three independent genetic approaches, we identified variants in MmpL5 that both increase and decrease bedaquiline efflux. These variants converge on a site the lower periplasmic cavity of MmpL5 that we propose is the binding site of bedaquiline.

26.06.2025 10:30 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance Bedaquiline, an antitubercular drug that targets ATP-synthase, is a key component of a new oral drug regimen that has revolutionized the treatment of multi drug resistant tuberculosis. Clinical bedaqu...

Bedaquiline resistance driven by the MmpS5L5 efflux pump is threatening the drug regimens used to treat MDR-TB.

In our new preprint, we used structural and genetic approaches to better understand how MmpS5L5 effluxes bedaquiline and how future resistance may evolve. πŸ§΅πŸ”½

#TBsky #MicroSky #TB

26.06.2025 10:30 β€” πŸ‘ 25    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1

Working link here! www.biorxiv.org/content/10.1...

25.06.2025 18:12 β€” πŸ‘ 7    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
πŸ”— All positions: ki.se/en/about-ki/...

25.06.2025 10:00 β€” πŸ‘ 81    πŸ” 79    πŸ’¬ 0    πŸ“Œ 3

@morwan.me is following 20 prominent accounts