Charlie Scarff

Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease at University of Leeds, listed on FindAPhD.com

PhD studentship available - great collaborative project with @antoncalabrese.bsky.social and Prof. Sarah Harris, Sheffield

07.11.2025 09:54 — 👍 1    🔁 0    💬 0    📌 0

No.9

24.06.2025 09:06 — 👍 0    🔁 0    💬 0    📌 0

Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

16.06.2025 18:54 — 👍 3    🔁 7    💬 0    📌 1

Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.

25.04.2025 16:40 — 👍 13    🔁 4    💬 1    📌 0

Swinging lever mechanism of myosin directly shown by time-resolved cryo-EM - Nature A study using time-resolved cryogenic electron microscopy reveals the swinging lever mechanism of myosin, providing information on the molecular basis behind the production of force and movement by my...

Swinging lever mechanism of myosin shown by time-resolved cryoEM www.nature.com/articles/s41... so glad to finally be able to share this with the community! @astburycentre.bsky.social @astbury-bsl.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social

09.04.2025 17:19 — 👍 74    🔁 30    💬 2    📌 3

Mavacamten inhibits myosin activity by stabilising the myosin interacting-heads motif and stalling motor force generation Most sudden cardiac deaths in young people arise from hypertrophic cardiomyopathy, a genetic disease of the heart muscle, with many causative mutations found in the molecular motor beta-cardiac myosin...

Mechanism of mavacamten inhibition of myosin - check out our preprint here: www.biorxiv.org/content/10.1...

17.02.2025 20:03 — 👍 7    🔁 1    💬 0    📌 2

Having a wonderful time in Japan at the Institute for Protein Research, Osaka Uni International Conference. Fascinating and diverse protein research. Thank you!

17.01.2025 03:01 — 👍 6    🔁 0    💬 0    📌 0

Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com

www.findaphd.com/phds/project...

Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!

19.11.2024 12:01 — 👍 0    🔁 2    💬 0    📌 0

Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com

PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...

19.11.2024 12:03 — 👍 6    🔁 2    💬 0    📌 0

Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of cardiac myosin function in health and disease through molecular dynamic simulation and electron microscopy at University of Leeds, listed on FindAPhD.com

PhD studentship available! #AstburyCentre CryoEM & MD simulation to understand cardiac muscle function in health and disease Apply by 5th Jan www.findaphd.com/phds/project...

19.11.2024 12:03 — 👍 6    🔁 2    💬 0    📌 0

Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds on FindAPhD.com PhD Project - Making and breaking myosin filaments: How smooth muscle cells modulate their contractile behaviour. at University of Leeds, listed on FindAPhD.com

www.findaphd.com/phds/project...

Interested in smooth muscle contraction and wanting to study for a PhD? Project at #UniversityofLeeds #AstburyCentre Apply by 5th Jan!

19.11.2024 12:01 — 👍 0    🔁 2    💬 0    📌 0

Cheney PhD : The Astbury Centre for Structural Molecular Biology The Cheney Scholarship 4-year PhD Scheme in in situ structural biology Applications are now invited for up to 4 new scholarships, commencing in October 2025. The application deadline is Tuesday 3rd De...

4 Cheney PhD scholarships available in in situ structural biology - bench to bedside
@ScienceLeeds

@Astbury_BSL

@LeedsBRC

@LeedsMedHealth

@AstburyCentre
astbury.leeds.ac.uk/cheney-phd apply by 3rd December

13.11.2024 10:10 — 👍 2    🔁 0    💬 0    📌 0

Tomogram - Seeing into cells

13.11.2024 10:09 — 👍 0    🔁 0    💬 0    📌 0

Taking drug discovery towards cells and tissues - Register interest Join the Astbury Centre for a day focused on taking drug discovery into cells and tissues with the aim of driving translation.

Do you work in the life sciences sector & are interested in "Taking drug discovery towards cells and tissue – How can this drive translation?" Join
@AstburyCentre
for a 1-day meeting on 4th Apr 25 at the Royal Society for a day of talks, networking, & more astburyopeninnovation2025.eventbrite.com

13.11.2024 10:08 — 👍 0    🔁 0    💬 1    📌 0

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM Myosins are essential for producing force and movement in cells through their interactions with F-actin. Generation of movement is proposed to occur through structural changes within the myosin motor ...

Interested in how myosin generates movement? and how actin activates it? Check out our preprint: biorxiv.org/content/10.1...
@UoL_LICAMM

@AstburyCentre

Beautiful collaborative effort!!

13.11.2024 10:07 — 👍 0    🔁 0    💬 0    📌 0