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Felix Campelo

@felixmendu.bsky.social

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427 Followers  |  529 Following  |  52 Posts  |  Joined: 29.11.2023  |  2.24

Latest posts by felixmendu.bsky.social on Bluesky

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𝐎π₯𝐠𝐚 π•πšπ₯𝐯𝐞𝐫𝐝𝐞, head of the research group GReNeC-Neurobio,Β is the new director of the Department of Medicine and Life Sciences (MELIS) at @upf.eduΒ 

πŸ‘‰Valverde will be the first female director of the department. With her there are currently 3 women leading PRBB institutions

ℹ️https://tuit.cat/N3ms3

28.07.2025 08:12 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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1/2 Interesting read: The authors by the original "arsenic instead of phosphorous can sustain life" paper in Science write why they disagree with the Retraction. It's indeed a tricky question. The original paper was clearly wrong, but there was no data fabrication.
www.science.org/doi/10.1126/...

25.07.2025 06:25 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 4    πŸ“Œ 0

very excited to be part of this!

22.07.2025 18:45 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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(again!) new publication for @membramics-lab.bsky.social, by @carlaalemany.bsky.social & @julianedagraca.bsky.social

in collaboration with N Naffakh & JB Brault, we show that Influenza virus triggers an ATG16L1/Rab11 PI4P response at ER membrane for viral export

journals.plos.org/plosbiology/...

17.07.2025 14:02 β€” πŸ‘ 13    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

πŸ—“οΈSave the date for our mini-symposium

Thursday 25 September, 15:00-17:00 BST (GMT+1)

Our keynote speaker is Gillian Griffiths
@griffithslab.bsky.social, who will share their research on β€˜Unexpected membrane dynamics in T cells’.

#membranetrafficking #FocalPlaneFeatures

16.07.2025 13:45 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane FocalPlane features... membrane trafficking - apply to give a talk - News

πŸ“’Call for speakers

We are looking for ECRs to speak in our mini-symposium run together with the popular membrane trafficking webinar series organised by β€ͺ@franbottanelli.bsky.social @felixmendu.bsky.social & @ishier.bsky.social.

focalplane.biologists.com/2025/07/14/f...

Apply by 24 August

16.07.2025 13:41 β€” πŸ‘ 19    πŸ” 19    πŸ’¬ 0    πŸ“Œ 1
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Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS Despite extensive efforts to develop strategies to inhibit cancer metastasis—the leading cause of cancer-related deaths—progress has been limited i...

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS www.pnas.org/doi/abs/10.1...

15.07.2025 08:05 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane FocalPlane features... membrane trafficking - apply to give a talk - News

With @ishier.bsky.social and @franbottanelli.bsky.social, we're helping @focalplane.bsky.social organize a #FocalPlanFeatures ... on membrane trafficking happening Sept. 25th! Keynote by Gillian Griffiths @yale.edu. Calling all ECRs: apply to give a talk focalplane.biologists.com/2025/07/14/f...

15.07.2025 07:41 β€” πŸ‘ 17    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

congratulations Carmen!!!

14.07.2025 10:52 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
T cell protrusions enable fast, localised initiation of CAR signalling Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and immune signalling initiation. To investigate how membrane protrusions initiate and contribute to signalling, from the first cell-cell contact to immunological synapse formation, we performed dynamic imaging experiments of endogenously tagged signalling proteins in T cells. To quantitatively capture the early dynamics of cell-cell interactions, we employed HER2‑CAR-expressing T cells targeting HER2⁺ breast cancer cells. By harnessing live-cell imaging and super-resolution stimulated emission depletion (STED) microscopy we were able to capture topological membrane changes and their correlation with mesoscale protein rearrangements over time. Our findings indicate that, prior to activation, key molecular players in T cell activation, including the kinase Lck, the phosphatase CD45 and the adaptor LAT, as well as the exogenously expressed CAR, lack any enrichment in actin-rich protrusions. However, upon initial contact of the T cell with the target cell, a dynamic and fast rearrangement of the surface receptors, phosphatases, and kinases occurs within the protrusions, ensuring a rapid and effective initiation of the immune signalling cascade. The rapid clustering of the HER2-CAR occurs preferentially within protrusions rather than flat membrane regions and is accompanied by enhanced recruitment of the kinase ZAP-70 and LAT. While the localisation of the kinase Lck remained unchanged, protrusion-cell contacts trigger a pronounced exclusion of the phosphatase CD45, an effect observed both with and without the cytosolic signalling domain of the CAR. Overall, the signalling machinery rearranged more rapidly and efficiently at contacts mediated by protrusive structures compared to non-protrusive regions. Together, our data provide a quantitative framework illustrating how signalling proteins are dynamically reorganised to facilitate CAR-mediated activation within these specialised structures. ### Competing Interest Statement The authors have declared no competing interest.

Check out our new preprint on the role of T cell actin-rich protrusion in CAR signalling initiation.
Spoiler alert: Protrusions do it better
www.biorxiv.org/content/10.1...

09.07.2025 12:50 β€” πŸ‘ 29    πŸ” 5    πŸ’¬ 3    πŸ“Œ 3
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T cell protrusions enable fast, localised initiation of CAR signalling Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and i...

For #TcellThursday I am going to repost our recent work where we use CRISPR and imaging to highlight the role of protrusions in early T cell signaling. I think Carmen’s work beautifully shows how one can extract quant info by imaging processes as they happen in cells! www.biorxiv.org/content/10.1...

10.07.2025 13:27 β€” πŸ‘ 16    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1
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The endoplasmic reticulum proteostasis network and bone disease Bone homeostasis relies on the coordinated activity of osteoblasts and osteoclasts that balances bone formation and resorption, and of osteocytes for biomechanical sensing and hormone secretion. A key...

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

11.07.2025 09:22 β€” πŸ‘ 24    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
Find me in the FocalPlane Network

Find me in the FocalPlane Network

Looking for new #microscopy collaborations, organising speakers for a conference, assembling a committee?

Visit and join the @focalplane.bsky.social network to broaden your contacts and find those who may not come to mind.

focalplane.biologists.com/network

#Microscope #Imaging #CellBiology

08.07.2025 08:39 β€” πŸ‘ 7    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...

07.07.2025 14:05 β€” πŸ‘ 53    πŸ” 49    πŸ’¬ 0    πŸ“Œ 1
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Intracellular mechanics and organelle mechanobiology Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

Sign up now for EMBO Workshop "Intracellular mechanics and organelle #mechanobiology" in Barcelona, Spain, 16–20 Feb 2026!

Registration Deadline (in person/virtual): 15 Dec 2025/1 Feb 2026
Abstract Submission Deadline: 14 Nov 2025

meetings.embo.org/event/26-org...
#EMBOmechanobio #EMBOevents πŸ§ͺ

05.07.2025 07:01 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 2    πŸ“Œ 0
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Intracellular mechanics and organelle mechanobiology Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! πŸ™ #EMBOmechanobio

meetings.embo.org/event/26-org...

04.07.2025 15:50 β€” πŸ‘ 56    πŸ” 36    πŸ’¬ 1    πŸ“Œ 1
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πŸ“’ Save the date! Join us for MINDLAB, an interdisciplinary training on neuroscience and #photonics, exploring the brain from molecules to whole organisms.

πŸ—“οΈ 4–7 Nov 2025
πŸ“ ICFO

More details soon!

#MINDLAB #Photonics #Neuroscience #ICFO #SaveTheDate

04.07.2025 07:14 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Let's Review II Good afternoon! Buenos tardes, Buon pomeriggio, Guten tag, Jo napot, Boa tarde, God eftermiddag, Nuq'neH! (Okay, in Klingon this translates to β€˜What do you want?’ but it is the traditional response wh...

Let's Review II url: journals.biologists.com/jcs/article/...

02.07.2025 15:39 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

And to all of you who are searching and applying for jobs: it can get tough (really tough), and motivation can go down, but don’t lose hope. Keep pushing, and the right opportunity will come! And focus on the science, I still believe it always pays off :) (3/3)

28.06.2025 16:42 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

I’m deeply grateful for this opportunity to continue doing the research I love in such a wonderful environment. And a huge thanks to everyone who made this possible (from past and present lab members, colleagues & collaborators, friends and support buddies, etc.) (2/3)

28.06.2025 16:42 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Photograph of the PRBB building in Barcelona, where the MELIS-UPF research department is located.

Photograph of the PRBB building in Barcelona, where the MELIS-UPF research department is located.

After almost ten years at @icfo.eu, I’m excited to share that next month I’ll join the Medicine and Life Sciences department at @upf.edu as a Group Leader in Quantitative Biology, in Barcelona’s @prbb.org, the largest biomedical research hub in Southern Europe! (1/3)

28.06.2025 16:42 β€” πŸ‘ 50    πŸ” 2    πŸ’¬ 8    πŸ“Œ 2

This is tomorrow (Thursday), looking forward to it! #MembraneTrafficking

25.06.2025 16:37 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Switzerland job with University of Bern, Institute of Cell Biology | 12840798 Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.

We’re hiring! Join us as a TT assistant professor in quantitative cell biology @UniBE. We’re looking for an experimentalist (bonus: modeling/ML/computer vision). Vibrant research, Alps nearby. πŸ”οΈ Details: shorturl.at/PKUDU
DM me with questions!
#AcademicJobs #QuantBio #CellBiology

25.06.2025 13:26 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
MEMBRANE TRAFFICKING | Membrane Trafficking

As always, more info here: felixcampelo.wixsite.com/membranetraf...

23.06.2025 07:46 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
MEMBRANE TRAFFICKING | Membrane Trafficking

The #MembraneTrafficking online seminars are back this Thursday (June 26th, 5pm CEST). We'll hear from @jnuechel.bsky.social about how to find the right partner for a TANGO, and from Maohan Su about the organizational principles of the Golgi. @ishier.bsky.social @franbottanelli.bsky.social

23.06.2025 07:46 β€” πŸ‘ 16    πŸ” 14    πŸ’¬ 1    πŸ“Œ 2

Congratulations Markku! I'm very happy to hear that πŸ₯³

23.06.2025 06:39 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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This is my first post. We are very happy to share the following preprint!

Our work introduces a novel concept that the functional state of the ERES is maintained through the autoregulated phosphorylation–dephosphorylation cycle of key scaffold proteins.

www.biorxiv.org/content/10.1...

20.06.2025 21:22 β€” πŸ‘ 6    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Also, some times of the year are difficult for editors (during holiday seasons, exam and heavy teaching periods, etc.). But do ask the editorial office at @elife.bsky.social , they are there to help you and all the authors! Good luck with the paper!

17.06.2025 11:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

20 days is not typical but I'd say also not rare. At least in my case, as a senior editor, I try to get at least 2-3 rev. editors who carefully assess the manuscript before deciding (always thinking to be as fair as possible tp the authors). I think this is especially important in the new model.

17.06.2025 11:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (πŸ’‘+ 🦠 + βš½οΈπŸ’¨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

10.06.2025 15:52 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1

@felixmendu is following 20 prominent accounts