ππ₯π π πππ₯π―ππ«ππ, head of the research group GReNeC-Neurobio,Β is the new director of the Department of Medicine and Life Sciences (MELIS) at @upf.eduΒ
πValverde will be the first female director of the department. With her there are currently 3 women leading PRBB institutions
βΉοΈhttps://tuit.cat/N3ms3
28.07.2025 08:12 β π 6 π 2 π¬ 0 π 0
1/2 Interesting read: The authors by the original "arsenic instead of phosphorous can sustain life" paper in Science write why they disagree with the Retraction. It's indeed a tricky question. The original paper was clearly wrong, but there was no data fabrication.
www.science.org/doi/10.1126/...
25.07.2025 06:25 β π 8 π 3 π¬ 4 π 0
very excited to be part of this!
22.07.2025 18:45 β π 1 π 1 π¬ 0 π 0
(again!) new publication for @membramics-lab.bsky.social, by @carlaalemany.bsky.social & @julianedagraca.bsky.social
in collaboration with N Naffakh & JB Brault, we show that Influenza virus triggers an ATG16L1/Rab11 PI4P response at ER membrane for viral export
journals.plos.org/plosbiology/...
17.07.2025 14:02 β π 13 π 3 π¬ 1 π 1
ποΈSave the date for our mini-symposium
Thursday 25 September, 15:00-17:00 BST (GMT+1)
Our keynote speaker is Gillian Griffiths
@griffithslab.bsky.social, who will share their research on βUnexpected membrane dynamics in T cellsβ.
#membranetrafficking #FocalPlaneFeatures
16.07.2025 13:45 β π 3 π 2 π¬ 0 π 0
FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane
FocalPlane features... membrane trafficking - apply to give a talk - News
π’Call for speakers
We are looking for ECRs to speak in our mini-symposium run together with the popular membrane trafficking webinar series organised by βͺ@franbottanelli.bsky.social @felixmendu.bsky.social & @ishier.bsky.social.
focalplane.biologists.com/2025/07/14/f...
Apply by 24 August
16.07.2025 13:41 β π 19 π 19 π¬ 0 π 1
FocalPlane features... membrane trafficking - apply to give a talk - FocalPlane
FocalPlane features... membrane trafficking - apply to give a talk - News
With @ishier.bsky.social and @franbottanelli.bsky.social, we're helping @focalplane.bsky.social organize a #FocalPlanFeatures ... on membrane trafficking happening Sept. 25th! Keynote by Gillian Griffiths @yale.edu. Calling all ECRs: apply to give a talk focalplane.biologists.com/2025/07/14/f...
15.07.2025 07:41 β π 17 π 7 π¬ 0 π 0
congratulations Carmen!!!
14.07.2025 10:52 β π 1 π 0 π¬ 0 π 0
T cell protrusions enable fast, localised initiation of CAR signalling
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and immune signalling initiation. To investigate how membrane protrusions initiate and contribute to signalling, from the first cell-cell contact to immunological synapse formation, we performed dynamic imaging experiments of endogenously tagged signalling proteins in T cells. To quantitatively capture the early dynamics of cell-cell interactions, we employed HER2βCAR-expressing T cells targeting HER2βΊ breast cancer cells. By harnessing live-cell imaging and super-resolution stimulated emission depletion (STED) microscopy we were able to capture topological membrane changes and their correlation with mesoscale protein rearrangements over time. Our findings indicate that, prior to activation, key molecular players in T cell activation, including the kinase Lck, the phosphatase CD45 and the adaptor LAT, as well as the exogenously expressed CAR, lack any enrichment in actin-rich protrusions. However, upon initial contact of the T cell with the target cell, a dynamic and fast rearrangement of the surface receptors, phosphatases, and kinases occurs within the protrusions, ensuring a rapid and effective initiation of the immune signalling cascade. The rapid clustering of the HER2-CAR occurs preferentially within protrusions rather than flat membrane regions and is accompanied by enhanced recruitment of the kinase ZAP-70 and LAT. While the localisation of the kinase Lck remained unchanged, protrusion-cell contacts trigger a pronounced exclusion of the phosphatase CD45, an effect observed both with and without the cytosolic signalling domain of the CAR. Overall, the signalling machinery rearranged more rapidly and efficiently at contacts mediated by protrusive structures compared to non-protrusive regions. Together, our data provide a quantitative framework illustrating how signalling proteins are dynamically reorganised to facilitate CAR-mediated activation within these specialised structures. ### Competing Interest Statement The authors have declared no competing interest.
Check out our new preprint on the role of T cell actin-rich protrusion in CAR signalling initiation.
Spoiler alert: Protrusions do it better
www.biorxiv.org/content/10.1...
09.07.2025 12:50 β π 29 π 5 π¬ 3 π 3
T cell protrusions enable fast, localised initiation of CAR signalling
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in cell migration. However, recent studies have uncovered their role in antigen surveillance and i...
For #TcellThursday I am going to repost our recent work where we use CRISPR and imaging to highlight the role of protrusions in early T cell signaling. I think Carmenβs work beautifully shows how one can extract quant info by imaging processes as they happen in cells! www.biorxiv.org/content/10.1...
10.07.2025 13:27 β π 16 π 4 π¬ 1 π 1
Find me in the FocalPlane Network
Looking for new #microscopy collaborations, organising speakers for a conference, assembling a committee?
Visit and join the @focalplane.bsky.social network to broaden your contacts and find those who may not come to mind.
focalplane.biologists.com/network
#Microscope #Imaging #CellBiology
08.07.2025 08:39 β π 7 π 7 π¬ 0 π 0
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
07.07.2025 14:05 β π 53 π 49 π¬ 0 π 1
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to meβ¦
Sign up now for EMBO Workshop "Intracellular mechanics and organelle #mechanobiology" in Barcelona, Spain, 16β20 Feb 2026!
Registration Deadline (in person/virtual): 15 Dec 2025/1 Feb 2026
Abstract Submission Deadline: 14 Nov 2025
meetings.embo.org/event/26-org...
#EMBOmechanobio #EMBOevents π§ͺ
05.07.2025 07:01 β π 9 π 4 π¬ 2 π 0
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to meβ¦
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! π #EMBOmechanobio
meetings.embo.org/event/26-org...
04.07.2025 15:50 β π 56 π 36 π¬ 1 π 1
π’ Save the date! Join us for MINDLAB, an interdisciplinary training on neuroscience and #photonics, exploring the brain from molecules to whole organisms.
ποΈ 4β7 Nov 2025
π ICFO
More details soon!
#MINDLAB #Photonics #Neuroscience #ICFO #SaveTheDate
04.07.2025 07:14 β π 4 π 2 π¬ 0 π 0
And to all of you who are searching and applying for jobs: it can get tough (really tough), and motivation can go down, but donβt lose hope. Keep pushing, and the right opportunity will come! And focus on the science, I still believe it always pays off :) (3/3)
28.06.2025 16:42 β π 10 π 1 π¬ 0 π 0
Iβm deeply grateful for this opportunity to continue doing the research I love in such a wonderful environment. And a huge thanks to everyone who made this possible (from past and present lab members, colleagues & collaborators, friends and support buddies, etc.) (2/3)
28.06.2025 16:42 β π 3 π 0 π¬ 1 π 0
Photograph of the PRBB building in Barcelona, where the MELIS-UPF research department is located.
After almost ten years at @icfo.eu, Iβm excited to share that next month Iβll join the Medicine and Life Sciences department at @upf.edu as a Group Leader in Quantitative Biology, in Barcelonaβs @prbb.org, the largest biomedical research hub in Southern Europe! (1/3)
28.06.2025 16:42 β π 50 π 2 π¬ 8 π 2
This is tomorrow (Thursday), looking forward to it! #MembraneTrafficking
25.06.2025 16:37 β π 3 π 2 π¬ 0 π 0
Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) - Bern, Switzerland job with University of Bern, Institute of Cell Biology | 12840798
Assistant Professor with tenure-track for Quantitative Cell Biology (80-100%) at the University of Bern, Switzerland.
Weβre hiring! Join us as a TT assistant professor in quantitative cell biology @UniBE. Weβre looking for an experimentalist (bonus: modeling/ML/computer vision). Vibrant research, Alps nearby. ποΈ Details: shorturl.at/PKUDU
DM me with questions!
#AcademicJobs #QuantBio #CellBiology
25.06.2025 13:26 β π 4 π 2 π¬ 0 π 0
MEMBRANE TRAFFICKING | Membrane Trafficking
The #MembraneTrafficking online seminars are back this Thursday (June 26th, 5pm CEST). We'll hear from @jnuechel.bsky.social about how to find the right partner for a TANGO, and from Maohan Su about the organizational principles of the Golgi. @ishier.bsky.social @franbottanelli.bsky.social
23.06.2025 07:46 β π 16 π 14 π¬ 1 π 2
Congratulations Markku! I'm very happy to hear that π₯³
23.06.2025 06:39 β π 1 π 0 π¬ 0 π 0
This is my first post. We are very happy to share the following preprint!
Our work introduces a novel concept that the functional state of the ERES is maintained through the autoregulated phosphorylationβdephosphorylation cycle of key scaffold proteins.
www.biorxiv.org/content/10.1...
20.06.2025 21:22 β π 6 π 3 π¬ 0 π 0
Also, some times of the year are difficult for editors (during holiday seasons, exam and heavy teaching periods, etc.). But do ask the editorial office at @elife.bsky.social , they are there to help you and all the authors! Good luck with the paper!
17.06.2025 11:40 β π 1 π 0 π¬ 1 π 0
20 days is not typical but I'd say also not rare. At least in my case, as a senior editor, I try to get at least 2-3 rev. editors who carefully assess the manuscript before deciding (always thinking to be as fair as possible tp the authors). I think this is especially important in the new model.
17.06.2025 11:40 β π 0 π 0 π¬ 1 π 0
Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (π‘+ π¦ + β½οΈπ¨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social
10.06.2025 15:52 β π 11 π 4 π¬ 0 π 1
Cell and developmental biologist fascinated by forces, signaling and fate π¦π New PI @IMPvienna @viennabiocenter
@dfg.de Walter Benjamin Fellow & Postdoctoral Researcher @yap-lab.bsky.social | Co-organizer @epimechfc.bsky.social | Mechanobiology - Cell & Tissue Mechanics - Soft Matter Physics - Image Analysis
π https://julia-eckert.github.io
Scientists using microscopes, math, physics and fun to discover how cells work @Duke Cell Biology/BME. https://gladfelterlab.net
EMBO is the organization of more than 2,100 leading researchers that promotes excellence in life sciences in Europe and beyond.
https://www.embo.org/
PhD student @upc.edu | Researching how forces shape life | mechanobiology group @LaCΓ‘N
Scientist. Interested in complexity, organisational principles, quantitative biology, infographics, frogs & coffee. Opinions here are my own.
Life scientist.
Head of EMBO Membership & Elections and Courses & Workshops @embo.org #EMBOevents
previously: Editor at Molecular Systems Biology, EMBO Press
Views my own
Cell division and morphognesis
minclab.fr
Cell migration and endocytosis research lab
https://cytoskeleton.wixsite.com/krauselab
I love biophysics, jazz, poetry, and activism, especially when mixed together!
Into active matter, cell migration, phase separation, and active turbulence.
JdC postdoc at University of Barcelona, previously at MPI PKS Dresden and Uni Augsburg
Assistant Professor @biozentrum.unibas.ch β’ Theoretical biophysics β’ Postdoc ISTAustria, PhD LMU Munich, MSc Cambridge University
www.biozentrum.unibas.ch/brueckner
Perfil oficial del Servei de Recerca @upf.edu
π‘ Descobreix la recerca a la UPF i les oportunitats de finanΓ§ament!
π T'actualitzem amb novetats, recursos i suport per al personal investigador.
Stay updated on UPF's research & funding opportunities! π
Scientist & Communicator. Fascinated by cells across scales - π, π¬and β³. PI @GIMM, EMBO member. Former Director @IGC, PD @Cambridge University, PhD @UCL/IGC. My motto: "Science from all for all". Mom of 2 wonderful girls. Views are my own.
Physicist trying to understand the behaviour of living organisms. Group leader at EMBL Barcelona.
Biophysicist | genotype-phenotype maps, fitness landscapes and evolution | Independent Fellow leading a group at @barcelonacollaboratorium.com @crg.eu
interested on eating, both in IRL and in the lab π² epithelial phagocytosis of apoptotic cells | mechanobiology | early embryo error correction π
PhD student at Ruptecht Lab @crg.eu / @prbb.org