Mechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
www.nature.com/articles/s41...
06.11.2025 09:08 — 👍 4 🔁 1 💬 0 📌 0
Deletion of the TRPV1 #Ionchannels attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure
physoc.onlinelibrary.wiley.com/doi/10.1113/...
05.11.2025 11:39 — 👍 0 🔁 0 💬 0 📌 0
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
03.11.2025 18:28 — 👍 0 🔁 0 💬 0 📌 0
Sclareol and cinnarizine are non-selective inhibitors of voltage-gated Cav1.3 L-type Ca2+ #ionchannels Open access.
www.tandfonline.com/doi/full/10....
31.10.2025 11:39 — 👍 0 🔁 0 💬 0 📌 0
Mouse retinal ganglion cells and night blindness |
TRPM1 #ionchannels, mGluR6 of retinal ON bipolar cells
J.General Physiol. rupress.org/jgp/article/...
22.10.2025 10:39 — 👍 0 🔁 0 💬 0 📌 0
Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology
Paywalled
bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
21.10.2025 10:39 — 👍 2 🔁 0 💬 0 📌 0
Piezo1 #ionchannels regulate the mechanotransduction of soft matrix viscoelasticity | Nature Communications www.nature.com/articles/s41...
20.10.2025 17:35 — 👍 1 🔁 0 💬 0 📌 0
Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology
physoc.onlinelibrary.wiley.com/doi/10.1113/...
17.10.2025 10:39 — 👍 1 🔁 0 💬 0 📌 0
Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience
www.nature.com/articles/s41...
14.10.2025 10:39 — 👍 1 🔁 0 💬 0 📌 0
Curious… what’s up?
#IonChannels
Expression of Concern www.tandfonline.com/doi/full/10....
13.10.2025 17:28 — 👍 0 🔁 0 💬 0 📌 0
Voltage-gated sodium #IonChannels: Mechanisms, disease, and a growing research community *Special Issue* Journal of General Physiology.
rupress.org/jgp/article/...
12.10.2025 10:39 — 👍 3 🔁 1 💬 0 📌 0
Fatigue arising from KATP SUR2 gain-of-function in Cantu syndrome mice Scala -> Nichols. £€$¥
rupress.org/jgp/article/...
TLDR: Cantu syndrome -> muscle fatigue via overactive KATP #Ionchannels. Reversed by glibenclamide, suggesting possible new treatment.
11.10.2025 17:28 — 👍 2 🔁 1 💬 0 📌 0
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications
www.nature.com/articles/s41...
11.10.2025 10:39 — 👍 1 🔁 0 💬 0 📌 0
Abstract
Delta-type glutamate receptors are ligand-gated #ionchannels |Nature
£$¥€
www.nature.com/articles/s41...
10.10.2025 10:39 — 👍 0 🔁 0 💬 0 📌 0
TLDR: CBD alone doesn’t stop drug-resistant epilepsy. But paired with GABAergic meds like phenobarbital or diazepam, it cuts mortality and resistance. But combining with sodium channel blockers may worsen seizures www.frontiersin.org/journals/pha...
#IonChannels
09.10.2025 08:08 — 👍 2 🔁 1 💬 0 📌 0
Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
www.nature.com/articles/s41...
08.10.2025 18:44 — 👍 0 🔁 0 💬 0 📌 0
Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications
www.nature.com/articles/s41...
08.10.2025 15:35 — 👍 1 🔁 0 💬 0 📌 0
A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology www.nature.com/articles/s42...
Open access
08.10.2025 10:39 — 👍 0 🔁 0 💬 0 📌 0
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation - Wang - Aging Cell - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
04.10.2025 17:28 — 👍 0 🔁 0 💬 0 📌 0
Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
13.06.2025 10:39 — 👍 1 🔁 0 💬 0 📌 0
ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.14814...
10.06.2025 10:39 — 👍 1 🔁 0 💬 0 📌 0
Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press rupress.org/jgp/article/...
08.06.2025 10:39 — 👍 0 🔁 0 💬 0 📌 0
Raw ephys data. Lovely looking patch clamp whole cell.
Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic academic.oup.com/brain/advanc...
07.06.2025 17:28 — 👍 3 🔁 0 💬 0 📌 0
Raw data
The molecular transition that confers voltage dependence to muscle contraction | Nature Communications www.nature.com/articles/s41...
#ionchannels
07.06.2025 10:39 — 👍 1 🔁 0 💬 0 📌 1
Electrophysiological records
The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable #ionchannel (never heard of it before) - Nature Communications www.nature.com/articles/s41...
06.06.2025 10:39 — 👍 2 🔁 0 💬 0 📌 0
Small molecule blockers illustration
Identification of druggable binding sites and small molecules as modulators of TMC1 | Communications Biology
www.nature.com/articles/s42...
#ionchannels
05.06.2025 08:08 — 👍 1 🔁 0 💬 0 📌 0
Electrophysiological data image.
A short intrinsically disordered region at KtrB’s N-terminus facilitates allosteric regulation of K+ #ionchannel KtrAB | Nature Communications
www.nature.com/articles/s41...
04.06.2025 10:39 — 👍 3 🔁 1 💬 0 📌 0
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature
#ionchannels
www.nature.com/articles/s41...
02.04.2025 10:39 — 👍 4 🔁 2 💬 0 📌 0
Nicotinic acetylcholine receptor #ionchannels regulate growth hormone in pituitary somatotrophs
…in tigers…
www.nature.com/articles/s42...
01.04.2025 10:39 — 👍 2 🔁 0 💬 0 📌 0
Dean of Undergraduate Studies
Worcester Polytechnic Institute
Membrane Biophysicist, Lipid mediated signaling
Ski & Diving enthusiast, enjoys all kinds of sports & hiking
The Singh lab focuses on intracellular ion channels and their roles in cardiac physiology.
https://u.osu.edu/singhresarchlab/
Instituto Biofisika (EHU-UPV, CSIC)
doctoral student I fascinated by neurons, biophysics, ephys I Passion for olfaction: detection ➡️ processing ➡️ behavior🧠👃🏻 🐭
@chemosensation/Spehr lab (📍Aachen, Germany).
New reading material: doi.org/10.1523/JNEUROSCI.2134-24.2025
Opinions r my own!
Academic and ion channel pharmacologist at the University of Leeds. I've finally made it over to this platform. Posting mainly about #ionchannels and maybe occasionally about wine, gin, holidays and silly things that I get up to.
Ex- neuroscientist used to patch stuff and still crazy about how circuits work. Feminist | Traveler | Coffee addict. Formerly with Turrigiano Lab @Brandeis. 🧠👩🔬🚴♀️📷🏳️🌈 She/Her/她. 讲中文.
https://orcid.org/0000-0003-1422-856X
Links+follows related to: Ehlers-Danlos + Lyme + MEcfs + Autoimmune (Myasthenia Gravis, Sjogren’s, Hashimoto’s) + POTS + Mast Cell + ApoE (4/4) + Bilateral Vestibulopathy + BPPV + SIBO + migraine + mito myopathy + Long COVID + LMCA & Celiac Artery Stenosis
Precision Biophysics and Neuroscience
The Journal of Physiology publishes original research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.
@ShrinersStLouis @wustlortho @washubme @washudevbio @wustlCRM @theNAMedicine @theNAEng @AcadofInventors @cytexortho @MyAOCConnect #racquetball
A peer-reviewed, online, Open Access journal publishing across all areas of physiology. A collaboration between The Physiological Society and the American Physiological Society.
Website: https://physoc.onlinelibrary.wiley.com/journal/2051817x
TRP channel nerd. Vascular physiology, ion channels, Ca2+ signaling, neurovascular coupling. Biodiversity, conservation, and amateur astronomy.
Physiological functions and pathological alterations in vascular ion channels
https://jaggar.lab.uthsc.edu/
Synapse modulation, biophysics, optogenetics, opsins, optoGPCRs & channelrhodopsins... garden stuff, photography, cats, cycling, parenting...still postdocing. Patch-clamper with imaging ambitions
https://scholar.google.com/citations?user=4xDsEF4AAAAJ&hl=en
Science and Public Education.
https://www.reddit.com/r/evolution/comments/pn913k/fundamental_preschool_level_science_basics_for/
Also:
https://gaulintracksite.blogspot.com/
https://en.wikipedia.org/wiki/Gaulin_Dinosaur_Tracksite
A gold open access journal that publishes short papers and regular articles in all disciplines encompassed by biophysics. Editor-in-Chief: Joerg Enderlein.
The premier journal of quantitative biology and leading journal for molecular, cellular, and systems biophysics research. Editor-in-Chief: Vasanthi Jayaraman.
