Infinity Bio Inc

Diagnosing TB in children is a persistent challenge, as sputum-based tests are often ineffective. A new study used advanced plasma proteomics to identify a non-sputum-based biosignature for TB. The identified signatures meet WHO accuracy guidelines for a pediatric TB diagnostic.
Read: rdcu.be/eOtzp

Diagnosing Lyme disease in the nervous system is slow & often requires an invasive spinal tap. A new study in Nature Communications used proteomics & machine learning to identify a diagnostic protein signature in plasma, crucial progress toward a less invasive test.
www.nature.com/articles/s41...

Infinity Bio, Inc. is excited to join the LoCITT trial, powering advanced antibody reactome profiling to uncover key immune signatures & improve long COVID treatment. Proud to partner with Scripps Research for remote scientific progress.
#LongCovid #LoCITT #AntibodyProfiling #Immunology

A study by Ruberto et al. profiled immune responses to HERV-W retrovirus proteins in Multiple Sclerosis patients. The findings suggest pHERV-W could be a valuable biomarker for predicting MS disease progression.
www.frontiersin.org/journals/imm...
#MultipleSclerosis #Immunology #InfectiousDisease

A groundbreaking study in Science creates a pan-disease blood atlas using proteomic 'fingerprints.' Analyzing 8262 individuals, they identified signatures for 59 diseases, found common biological themes, & developed a model that predicted lung cancer years before diagnosis.
#Proteomics #Biomarkers

For our "Cohort of the Week," we are celebrating a study by Parodis and colleagues that tackles the challenge of diagnosing Systemic Lupus Erythematosus (SLE).

Read the full paper: ard.eular.org/article/S000...
#Lupus #SLE #Autoimmune #Biomarkers #Diagnostics

Immune responses to common viruses may lower dementia risk. Older adults with higher antibodies to HCoV-OC43 showed better cognition and brain health, with IGDCC4 identified as a promising target for neurodegeneration prevention.
www.science.org/doi/10.1126/...
#Neuroscience #Alzheimers #Immunology

his week, we are inspired by groundbreaking research from the IMPACC study, published in JCI. In their paper, “A multi-omics recovery factor predicts long COVID in the IMPACC study,”
Read here: www.jci.org/articles/vie...
#LongCOVID #LC #MultiOmics #Biomarkers #PrecisionMedicine #IMPACC

Our "Cohort of the Week" is a study on Lupus Nephritis (LN). Researchers used immunophenotyping to find distinct immune signatures in patients that traditional methods missed, linking them to treatment outcomes. A major step toward personalized medicine for LN. Read here: www.jci.org/articles/vie...

Thrilled to announce our Early Access Grant winners: Dr. Jakob Kreye (Charité), Dr. Sergio Poli (Brigham & Women’s Hospital), & Dr. Aubree Gordon (University of Michigan). Supporting their research in autoimmune, infectious, & neurological autoimmune disorders with cutting-edge antibody profiling.

Webinar TOMORROW! 🧬 “How Measuring The Reactivities Of Circulating Antibodies Through Reactome Profiling Can Provide Novel Insights Into Human Health.”

Register here: www.labroots.com/ms/webinar/i...

#Webinar #Immunology #AntibodyProfiling #PrecisionMedicine #InfinityBio #BiomedicalResearch

Countdown: Just a few days till the Sep 17 webinar!
Hear from Katy Shaw-Saliba (Infinity Bio), Linda Kusner (GWU), Jessica Lasky-Su (Brigham/Harvard).
Register: www.labroots.com/ms/webinar/i...
#Webinar #Immunology #AntibodyProfiling #PrecisionMedicine #InfinityBio #BiomedicalResearch

Explore antibody profiling’s future!
Sep 17 webinar: “How Measuring The Reactivities Of Circulating Antibodies Through Reactome Profiling Can Provide Novel Insights Into Human Health.”
Sign up: www.labroots.com/ms/webinar/i...
#Immunology #AntibodyProfiling #PrecisionMedicine #BiomedicalResearch

A new study by @thushan-desilva.bsky.social @alexjkeeley.bsky.social & colleagues provides a framework for future Streptococcus pyogenes (Strep A) vaccine development by examining the natural acquisition of humoral immunity!

www.nature.com/articles/s41...
#Microbiology #Pathogen #VaccineDevelopment

Just 2 weeks left! Join us Sep 17 for “How Measuring The Reactivities Of Circulating Antibodies Through Reactome Profiling Can Provide Novel Insights Into Human Health.”

Register here : www.labroots.com/ms/webinar/i...

Proteogenomic signature of Alzheimer’s disease and related dementia risk in individuals with major depressive disorder - Nature Mental Health This study investigates biological mechanisms connecting major depressive disorder to Alzheimer’s disease risk, identifying six key proteins and establishing a proteomic risk score with strong predict...

New Cohort of the Week! A groundbreaking proteogenomic study links major depressive disorder (MDD) to an increased risk for Alzheimer's disease and related dementia (ADRD).

Full paper: nature.com/articles/s44...

#Neuroscience #Proteomics #ADRD #Dementia #MentalHealth #Omics

New Cohort of the Week! 🧠 A fascinating study from Stanford University used proteomics & GWAS to investigate the brain barrier system's role in aging & neurodegeneration.

Read the full paper: www.nature.com/articles/s41...
#Neuroscience #Proteomics #GWAS #BrainHealth #Omics

Excited to announce our upcoming webinar on September 17, 2025 , “How Measuring The Reactivities Of Circulating Antibodies Through Reactome Profiling Can Provide Novel Insights Into Human Health" Join us for a dynamic session!

Register here: www.labroots.com/ms/webinar/i...

New Cohort of the Week 🧠: Maternal Immune Activation and Risk of Child Neurodevelopmental Disorders. Univ. of Copenhagen study links maternal inflammatory proteins (IL-6, VEGFA, CD5) to ADHD & autism risk at age 10.

jamanetwork.com/journals/jam...

Our "Cohort of the Week" is here! We are highlighting an inspiring study on severe malaria, and how a multi-omics approach is revolutionizing our understanding of host-pathogen interactions. 🔬 #Malaria #Biomarkers
www.cell.com/immunity/ful...

New #CohortOfTheWeek from Infinity Bio! Latent #EBV infection surprisingly impacts #Type1Diabetes treatment efficacy! Yale researchers found EBV-positive patients show improved responses to teplizumab. #Immunology #AutoimmuneDisease
[Link: www.nature.com/articles/s41...

#CohortOfTheWeek A pivotal study on the association of anti-viral antibodies & neural autoantibodies in psychiatric disorders. Analyzing CSF/serum from patients, they found a significant link, suggesting CNS viral infection could trigger autoantibody generation
pubmed.ncbi.nlm.nih.gov/40382511/

VirSIGHT™ maps the viral antibody reactome—revealing infection & vaccine history. Discover how Infinity Bio’s MIPSA-powered platform advances viral immunity research: www.infinitybio.com/wp-content/u... #ViralImmunity #AntibodyResearch #ImmunologyInnovation

Infinity Bio’s Cohort of the Week: Bos & Zambrana find inapparent DENV; Kasbergen & Koopmans track ZIKV. Multiplex serology reveals infection dynamics.
www.thelancet.com/journals/lan...
academic.oup.com/jid/advance-...

Our Cohort of the Week is a Danish study (British Journal of Cancer) using patient data to identify cancer prognostic biomarkers in Type 2 Diabetes. YKL-40 & CRP show promise as prognostic markers, but vary in their power based on cancer type www.nature.com/articles/s41...

🌟 Cohort Study of the Week! 🌟 From derosalab.bsky.social Gut dysbiosis linked to survival in 955 cancer patients. The balance of Akkermansia & sMAdCAM-1 are crucial for prognosis. Important #PrecisionOncology!

pubmed.ncbi.nlm.nih.gov/40189749/
#CancerResearch #Microbiome #Oncology

Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Cohort study: “Plasma proteome variation and its genetic determinants in children and adolescents” by @liliniu.bsky.social Simon Rasmussen, Torben Hansen, mannlab.bsky.social maps 1,200+ proteins & genetic drivers in 2,100+ youth
#MassSpectroscopy #Plasma #Proteomics www.nature.com/articles/s41...

Cohort Study of the Week: Oh & Wyss-Coray from Stanford University show in Nature Medicine that the CSF YWHAG:NPTX2 ratio predicts cognitive decline years before Alzheimer’s symptoms, outperforming traditional biomarkers.

#AlzheimerDisease #CSFBiomarkers #Proteomics

www.nature.com/articles/s41...

𝗖𝗼𝗵𝗼𝗿𝘁 𝘀𝘁𝘂𝗱𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘄𝗲𝗲𝗸 “𝗦𝗼𝗰𝗶𝗮𝗹 𝗱𝗶𝘀𝗮𝗱𝘃𝗮𝗻𝘁𝗮𝗴𝗲 𝗮𝗰𝗰𝗲𝗹𝗲𝗿𝗮𝘁𝗲𝘀 𝗮𝗴𝗶𝗻𝗴” Nature Med 2025 by @mikakivimaki.bsky.social & Joni V. Lindbohm links 14-protein plasma signatures to accelerated aging & disease risk via immune pathways.
#ProteomicSignatures #AgingBiomarkers #Reactome
www.nature.com/articles/s41...

Cohort study of the week “Proteomic changes upon treatment with semaglutide in individuals with obesity” (Nature Medicine Jan 2025) by Lasse Maretty, Abd Tahrani & Milan Geybels reveals proteomic shifts in STEP 1 & 2 trials #Semaglutide #GLP1ReceptorAgonist #Proteomics www.nature.com/articles/s41...