Jan Gründemann

Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing interneurons of the basolateral amygdala https://www.biorxiv.org/content/10.1101/2025.10.07.680627v1

👀“experience of a punished outcome generates a BLA representation that is selectively replayed when animals subsequently abort choice of the large/risky reward option.”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”

🔬 Join us for the next iBehave Seminar Series 2025 lecture with Prof. Dr. Mark Schnitzer @Stanford on Oct 9, 11:00 DZNE Bonn. Host: @jangrundemann.bsky.social

Title: Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics

📧 Zoom info: ibehave@uni-bonn.de

Sensory origin of visually evoked activity in auditory cortex Sound-evoked face movements in mice largely account for sound-driven activity in visual cortex. Yet visual stimuli rarely trigger face movements, and such movements fail to explain visually evoked res...

Sensory origin of visually evoked activity in auditory cortex
www.cell.com/cell-reports...

Travel awards are available for undergraduate students looking to attend #Cosyne25! The application is short, and the deadline is Nov 12. @cosynemeeting.bsky.social

Application: shorturl.at/6NEyk

More info: www.cosyne.org/travel-grants

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A couple of new preprints out from Kash Lab!

All-optical voltage interrogation for probing synaptic plasticity in vivo - Nature Communications Reliable measuring the voltage dynamics of individual neurons in the intact brain is significantly challenging. Here authors developed an all-optical method combining two-photon voltage imaging and optogenetics to measure and induce synaptic plasticity in vivo, revealing LTP of inhibition in cerebellar circuits and providing a blueprint to link synaptic changes to learning.

Using a new genetically-encoded voltage indicator in an all-optical approach to measure synaptic plasticity in awake behaving mice. Great work by @jacquescarolan.bsky.social and colleagues. Check out www.nature.com/articles/s41...

Human brain organoids record the passage of time over multiple years in culture https://www.biorxiv.org/content/10.1101/2025.10.01.679721v1

Exploring the correspondence between gene expressionand thalamic nuclei using the THALMANAC resource https://www.biorxiv.org/content/10.1101/2025.09.30.679413v1

Wow!

Why early birds sing early: rebound singing from nighttime suppression can explain dawn chorus Many birds sing intensively at dawn, a phenomenon known as the "dawn chorus," yet its cause remains unclear. This is largely due to prior research being limited primarily to ecological studies of wild...

Why early birds sing early
www.biorxiv.org/content/10.1...

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:

authors.elsevier.com/a/1lsO73QW8S...

Astrocytic Activation Completely Corrects Memory Performancein an Alzheimer's Disease Model https://www.biorxiv.org/content/10.1101/2025.09.29.679133v1

The Reinstatement of a Forgotten Infantile Memory https://www.biorxiv.org/content/10.1101/2025.09.27.678956v1

Postdoc Research Group Douglass Our Group Our newly established research group at ISTA is seeking a postdoctoral researcher to work on an ERC-funded project- HypoAdapt. We study how the brain controls bodily responses to environm...

We are hiring a postdoc to work @istaresearch.bsky.social on an @erc.europa.eu funded project, investigating the control of behavior and physiology by the hypothalamus. Please apply and share! ist.ac.at/en/job/postd...

Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice!

www.biorxiv.org/content/10.1...

#neuroskyence #compneurosky 🧪
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CS - plasticity and behavioral-state integration in the posterior insula during auditory fear learning https://www.biorxiv.org/content/10.1101/2025.09.25.678609v1

Brain-wide representational drift: memory consolidation and entropic force https://www.biorxiv.org/content/10.1101/2025.09.25.678547v1

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

www.nature.com/articles/s41...

Emergence of Functional Heart-Brain Circuits in a Vertebrate https://www.biorxiv.org/content/10.1101/2025.09.22.677693v1

A mechanistic theory of planning in prefrontal cortex https://www.biorxiv.org/content/10.1101/2025.09.23.677709v1

Neuronal detection of social actions directs collective escape behavior https://www.biorxiv.org/content/10.1101/2025.09.24.678087v1

Cortex-Wide Substrates for Body Schema and Action Awareness https://www.biorxiv.org/content/10.1101/2025.09.23.678085v1

Context rescales a social action code in a hormone-sensitive network https://www.biorxiv.org/content/10.1101/2025.09.24.678271v1

Not just an amazing dataset, excellent 3D pose, shape, and eye tracking in the real world! Bravo @trackingskills.bsky.social et al!

PS - Exactly this kind of data we predict will be critical for long-term health monitoring @monosovlab.bsky.social et al: www.sciencedirect.com/science/arti...

Spatial predictive coding in visual cortical neurons https://www.biorxiv.org/content/10.1101/2025.09.17.676794v1

#Cosyne2026 is now open for business!

Show us what you got both for the main meeting & workshop proposals 🧠🥳🧠🥳🧠

Hippocampal spreading depolarization as a driver of postictal ambulation Seizure-associated spreading depolarizations are potentially causing postictal symptoms in epilepsy.

Hippocampal spreading depolarization as a driver of postictal ambulation
www.science.org/doi/10.1126/...

Coherent dynamics of thalamic head-direction neurons irrespective of input While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The anterodorsal...

🚨New preprint alert!

The thalamus has long been seen as a relay of sensory signals to cortex.
But could it also generate its own structured activity?
Our study explores this question in the head-direction (HD) system.

Some explanation 🧵👇 1/13

www.biorxiv.org/content/10.1...

X Latin American School on Computational Neuroscience – LASCON 2026
University of São Paulo, Brazil
January 5-30, 2026
Application Deadline: October 4, 2025
sisne.org/en/lascon-x/