Riley Lab (UIC)

Spent a fantastic weekend at KU for the annual MIKIW conference. It was a blast showing the group where the magic all started. And we capped it off with Lisa Rusali bringing home the gold with an awesome oral presentation. #MIKIW2025 #noplacelikehome

27.04.2025 23:36 — 👍 2    🔁 0    💬 0    📌 0

Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine Akuammicine (1), an alkaloid isolated from Picralima nitida, is an agonist of the kappa opioid receptor (κOR). To establish structure–activity relationships (SARs) for this structurally unique κOR lig...

Also, shameless plug for our most recent paper that was part of this Special Issue where we explore the structure-activity relationship of akuammicine leading to the discovery of a new class of potent kappa opioid agonists: pubs.acs.org/doi/10.1021/...

05.12.2024 14:16 — 👍 4    🔁 1    💬 0    📌 0

With articles in J Med Chem, ACS Med Chem Lett, ACS Bio & Med Chem Au, the Journal of Nat Prod, ACS Chem Neurosci, and ACS Chem Bio, this VSI is an exciting reminder of the importance of natural products in medicinal chemistry and drug discovery!!

05.12.2024 14:10 — 👍 0    🔁 0    💬 1    📌 0

Check out this Virtual Special Issue on Natural Products Driven Medicinal Chemistry!! pubs.acs.org/page/vsi/nat...

05.12.2024 14:10 — 👍 5    🔁 0    💬 1    📌 0