Sergio Menchero

Paper alert! 🚨 Something new from us, and this time it's not sex chromosome related 😱 All led by @sermenchero.bsky.social who used the opossum as a model to understand developmental heterochrony. Transcriptional and morphological progression of dev programs are decoupled www.cell.com/developmenta...

Thank you, Isabel!

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Worth a read if interested in developmental timing & heterochronies.

What a beautiful work in an unusual model organism. Congrats Sergio et al!!!!

Gracias 😊

Thank you for sharing, Alfonso!

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

Remarkable finding supporting the existence of the interactions between two independent modules, #morphogenetic and #genetic, in #embryonic development. Acceleration of anterior genetic program in opossum @sermenchero.bsky.social‬ www.cell.com/developmenta...
short 🧵

Thank you! I hope so 😂

Thanks, Marta!

Thanks, Ali!

Thank you, Margarida!

Thanks, Roberta!

Thrilled to share the story stemming from my PhD!
We used mESC neural differentiation, genome editing and bulk & single-cell approaches to uncover how ZIC2 controls early neural fate by playing a dual and sequential regulatory role as a promiscous pioneer and a selective lineage-specific activator.

Thank you!

Thank you!

Bieeeeeen!! Gracias crack! Vamos a tope 💪

Thanks so much, Jessica

Thanks, Antoine!

Gracias Allan!

This project has been very special to me. I want to thank James @lab-turner.bsky.social who gave me the chance to build my own research line outside of the lab's main focus on sex chromosomes, and to our collaborators Chris Barrington, Clare Critcher, Waz Varsally, Greg Alanis @niakanlab.bsky.social

Further analysis identified #translation as a candidate control mechanism by which tissue prioritisation is achieved. For instance, the forelimb field had a higher protein synthesis rate than the hindlimb field

We found examples across multiple tissues: neural crest cells delaminate and migrate before neural tube closure, motor neurons form before spinal cord closure, patterning of the forelimb field precedes limb bud outgrowth… 💪🦵

🦘Marsupials develop #asynchronously⏳, prioritising the anterior part of the embryo. We found that transcriptional programs that form anterior structures initiate earlier and progress faster relative to morphological landmarks

Marsupial single-cell transcriptomics identifies temporal diversity in mammalian developmental programs Menchero et al. generate a single-cell transcriptomic atlas in the opossum and show rapid progression of transcriptional programs in specific tissues relative to morphological landmarks. This shift in...

Thrilled to share that our latest work on marsupial heterochrony is now online at @cp-devcell.bsky.social @cellpress.bsky.social @lab-turner.bsky.social @crick.ac.uk We used scRNAseq to understand the asynchronous progression of developmental programmes in marsupials www.cell.com/developmenta...

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health.

Apply here:
👉 RA: www.jobs.cam.ac.uk/job/51988/
👉 Postdoc: www.jobs.cam.ac.uk/job/51984/

Please share 🔬👩‍🔬

Excited to share our latest work with @jamesbriscoe.bsky.social .

A global #cis-regulatory temporal program guides how spatial cues are interpreted in neural progenitors. We show how #space and #time can be integrated to generate cell type diversity in the #spinalcord.

Congrats to all authors.

Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born

authors.elsevier.com/sd/article/S...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Beautiful! Another evolutionary strategy to deal with dosage compensation, this time in birds

This was a fantastic day #UKEvoDevo @qmulsbbs.bsky.social

Can using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷‍♀️🔧

If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology

royalsociety.org/science-even...