Sergio Menchero

Job alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk

Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️‍🩹

Full info below, and please share! 🫶🏻

bit.ly/467TO0M

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

The @neuroalc.bsky.social invites applications for two permanent research positions (Científico titular @csic.es , Tenure-track) to build independent programs in a collaborative, international environment. We welcome applicants from all demographic backgrounds 👇
in.umh-csic.es/en/ofertas/d...

We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!

Open access link: www.nature.com/articles/s41...

(1/9)

Congrats Nacho and all!!

Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes Nature Ecology & Evolution - Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms...

Our work on the evolution of the regulatory genome of echinoderms is now out in @natecoevo.nature.com. Led by my former PhD Marta Magri, Danila Voronov & Saoirse Foley. Great collaboration of Arnone, Hinman & Maeso labs, started long time ago with our missed José Luis Gomez-Skarmeta: rdcu.be/eXX8l

Escape from X inactivation is directly modulated by Xist noncoding RNA Nature Cell Biology - The authors show that increased Xist RNA levels can induce de novo silencing of genes that normally escape X inactivation. SPEN depletion prevents the silencing of escape...

Very happy to share our paper rdcu.be/eUImj out today in @natcellbio.nature.com 🎉🎉🎉
We uncover an unexpected role for endogenous Xist RNA in regulating X-linked genes that escape X-inactivation.

🍾🍾 amazing!

Want to image cells protecting the embryo during early development? We're hiring! 1 Postdoc, 1 PhD student, and 1 Research Technician. Come to Barcelona! www.embryobioimaging.com

Really fun, indeed! Thanks, Miguel!

🔔 Please share 🔔 I have two open developmental biology/genetics/evo-devo PhD project vacancies for October 2026 start.

1 = 🐚 🐌 🔬(embryos!!)
⏱️📆 DEADLINE 15th DEC 📆⏱️ (competition)
sleightlab.com/vacancies/

2 = 🦪 🐌 🧬
⏱️📆 DEADLINE 14th JAN 📆⏱️(fully funded)
sleightlab.com/phd-vacancy-2/

🙌🙌🙌

Thanks! And congrats to you as well!

The new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk

Join @mpercharde.bsky.social Lab at the MRC LMS! We have an 18mo postdoc position to cover a couple of projects (maternity leave and paper revisions). The projects are focussed on chromatin in early mouse embryos and metabolism in mouse embryonic stem cells and pluripotency.

LSI PhD programme | Living Systems Institute | University of Exeter

We are recruiting PhD students!

Two days left to apply for the LSI studentships - deadline Nov 26
www.exeter.ac.uk/research/ins...

and a few more for the SWBio studentships - deadline Dec 3
www.swbio.ac.uk/programme/pr...

Please repost or forward to prospective students that might be interested!

Scientific journals: we don’t want you using generative AI because it makes shit up.

Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote

Same journal: AI cover art which makes no sense? Oooh!

Our lab is actively looking for posdocs and there is NOW an Open Call for Postdoc contracts (3 years) here: www.aei.gob.es/en/announcem...

And the paper is finally out! Thank you to the reviewers for improving the content, and to everyone who contributed along the way. A very nice way of finishing the transition from Melbourne to Cambridge.

www.nature.com/articles/s41...

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

Poster advertising the 6th X-inactivation meeting from Oct 19-23 2026 in Sapporo, Japan. The organizers are Asato Kuriowa, Edda Schulz, Ikuhiro Okamoto, Rafael Galupa, Takashi Sado, Mitinori Saitou.

📣 SAVE THE DATE
Next X-inactivation meeting in Sapporo, Japan, 19-23 October 2026. Visit x-inactivation-meeting.org to join our mailing list. 🧬 speakers @dandergassen.bsky.social @marnieblewitt.bsky.social @heard65.bsky.social @crougeulle.bsky.social @sexchrlab.bsky.social @zhouqi1982.bsky.social

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

Exactly! It's great to see it's not a rare exception

Beautiful work confirming that DNA demethylation dynamics are different between eutherians and marsupials during early development 🦘 We knew about opossums but it's also true in dunnarts!

OFERTA DE EMPLEO (por favor difundir):

Ofrecemos un contrato predoctoral de 4 años asociado a nuestro proyecto PID2024-157249OB-I00. El objetivo del proyecto es evaluar un nuevo mecanismo patológico según el cual la competición entre promotores puede llegar a ocasionar enfermedades congénitas
👇

🚨 We're hiring! 🚨 Our lab at the University of Málaga, Spain🇪🇸 is looking for a bioinformatician researcher for a postdoc position (1+1 years). Check the ad, and if you're interested, get in touch!
📅 Starting date early 2026, with some flexibility.
🙏Please, RT!

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.

Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social

We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions
🧵👇

www.biorxiv.org/content/10.1...

Registro "Biología del Desarrollo Sintética: Diseñando la Vida" Curso Electivo de Verano, dirigido a estudiantes de pregrado Programa: Link Fechas: 5 al 15 de Enero de 2026 Lugar: Santiago de Chile, clases presenciales (Campus Manuel Montt, U. Mayor) Para estudian...

Help us to promote this DevBiol course (in Spanish)
¡Nuevo curso gratuito de Biología del Desarrollo (en español)!
Aprende sobre los procesos que dan origen a la vida
Cupos limitados → forms.gle/sfSV1GTae2nC...
Detalles y programa: drive.google.com/file/d/1-9dd...
#BiologíaDelDesarrollo

A human induced pluripotent stem cell toolbox for studying sex chromosome effects Sex chromosomes shape male (XY)-female (XX) differences in development and disease. These differences can be modeled in vitro by comparing XY and XX h…

Our latest 📢 We generated isogenic iPSCs with XX, XY, XO and XXY karyotypes to study sex chromosome effects 🧫 While XX and XY transcriptomes are similar, XO cells showed an important effect of the Y and inactive X @crick.ac.uk @stemcellreports.bsky.social www.sciencedirect.com/science/arti...