René Ketting

Was a pleasure to work together! (And it still is😊)

A genetic framework for RNAi inheritance in Caenorhabditis elegans | EMBO reports imageimageAn intergenerational cycle between HRDE-1 and WAGO-3 drives RNAi inheritance in C. elegans, where HRDE-1 drives silencing in both parent and offspring and WAGO-3 transmits the RNAi response ...

Very happy to be able to advertise our latest paper:

A genetic framework for RNAi inheritance in Caenorhabditis elegans | EMBO reports www.embopress.org/doi/full/10....

If you are an enthusiastic, motivated and team-oriented life science researcher-in-spé, we are looking for you! We offer excellent science and working conditions. For more info on projects please see. Please help me spread this🙏

www.imb.de/students-pos...

If you are an enthusiastic, motivated and team-oriented life science researcher-in-spé, we are looking for you! We offer excellent science and working conditions. For more info on projects please see. Please help me spread this🙏

www.imb.de/students-pos...

The Balbiani body is formed by microtubule-controlled molecular condensation of Buc in early oogenesis Kar et al. demonstrate that Balbiani body (Bb) formation is achieved via developmental condensation in zebrafish oogenesis, driven by Buc phase separation and evolving from a dynamic liquid-like state into a solid-like stable compartment. Multistep regulation by microtubules controls condensation, ensuring proper Bb formation and oocyte polarity.

💥Finally out!
Answering a two-centuries old question about a membraneless organelle that forms in #oocytes from insects to humans: the Balbiani body (Bb).
Now in
@currentbiology.bsky.social
:
cell.com/current-biol...
>

First #bluetorial. 🎉🎉 We’re very happy to share our latest biorxiv #preprint, just in time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. #TEsky #evosky #Celegans

Short 🧵 with highlights.

Transposable elements drive regulatory and functional innovation of F-box genes https://www.biorxiv.org/content/10.1101/2024.12.17.628972v1

University Professor of Life History Evolution W3 - Johannes Gutenberg-Universität Mainz Johannes Gutenberg-Universität Mainz looks for University Professor of Life History Evolution W3 in Mainz - apply now!

www.academics.com/jobs/univers...

Please help us find a new colleague at Mainz University. Thanks!
#evolbiol

Thanks for highlighting this work!

#RNAbiology #RNAsky

We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these!
And, please help me spread this. Thanks!

www.imb.de/jobs/jobdeta...

www.imb.de/jobs/jobdeta...

Universal Single Copy Knock-In System in Caenorhabditis elegans: One Plasmid to Target All Chromosomes https://www.biorxiv.org/content/10.1101/2024.12.06.627295v1

I’d like to join this pack. Thanks🙏
Hope this works as messaging is disabled for the @grothlab.bsky.social account

When you are looking for a nice place to set up your lab, definitely give this a good look. Feel free to approach if you have questions! Looking forward to many wonderful applications!

And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬

More details via www.imb.de/jobs
Application deadline is 5 January 2025

#sciencejobs #resilience #biostatistics

Join us in San Diego. A great meeting and also featuring the RNA Journal

New tool to map protease specificity may pave the way for improved treatments FMI researchers have developed a new tool that maps how proteases —enzymes that process proteins— cut their targets. This innovation offers new insight into the highly selective nature of proteases, w...

Researchers in @labgrosshans.bsky.social & their collaborators developed a tool that maps how proteases—enzymes that process proteins—cut their targets. The work, published in Molecular Systems Biology, could revolutionize drug design for conditions like diabetes. www.fmi.ch/news-events/...

And don't forget: many nematode species have lost them altogether! A huge puzzle.
doi.org/10.1002/wrna...

m6A sites in the coding region trigger translation-dependent mRNA decay Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

Interesting findings by the Zarnack and König labs:
www.cell.com/molecular-ce...
#RNAbiology

#RNASky #RNAbiology

Small RNA Biology starter pack, with a heavy bias towards our worm community! Just getting this started, and we'd like it to max out, so please message me if I've missed you (and apologies!)! go.bsky.app/HgPCPen

Excellent opportunity in Toronto.

Question to worm colleagues: do you know of a transgene that starts to be transcribed in Z2/3, and is not provided maternally?

Image representing the paper the Conformational ensembles of the human intrinsically disordered proteome

Happy to share the publication of the IDRome paper:
 
Conformational ensembles of the human intrinsically disordered proteome
 
Work led by Giulio Tesei and Anna Ida Trolle 
 
I'll post more later, but for now here is a link:
www.nature.com/articles/s41...

New publication from our group: An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori
www.embopress.org/doi/full/10....

We propose this may be how Piwi activity can be restricted environments suited for further piRNA production

Master's Thesis Opportunity! The Ameres lab is looking for a passionate master's student to delve into the mysteries of chemical RNA modifications ✨
➡️ Apply here: tinyurl.com/39hhkd7t

🚨🚨🚨🤝🧬🔍 We are recruiting group leaders for the #GenomeBiologyDepartment at the I2BC (France). Open to all relevant topics, with particular interest in RNA biology, chromatin organization, genome stability and gene expression. i2bc.paris-saclay.fr/jobs/ DM me for info! Please RT🙏

Enhanced transposable elements - Nature Reviews Cancer Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver cancer cell lines.

The non-coding repetitive genome as a source of regulatory DNA elements in cancer: a highlight of the recent work from
Biswajyoti Sahu: www.nature.com/articles/s41...