Ethan Bond

do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists

This app really should not require location permissions to work… something seems off.

Huh, looks like the key lesson from America’s detour into authoritarianism will be the same as every other: cowardice doesn’t pay.

Fukuyama works in mysterious ways

Protest at the Treasury in DC Tuesday 5PM. Pass it on.

Producing regulatory uncertainty to own the libs

Lots of profit to be had in preventing our democracy from crumbling

2.5 billion gallons per day are used to grow alfalfa which is then mostly fed to cows which are then mostly used as obscenely inefficient water-to-protein conversion machines.

Many such cases

Not that I’d recommend it in normal circumstances, but in such a pinch this seems like something a reader of both Arabic and English could achieve with AI even without medical training (assuming such a resource exists in English).

Found it! bsky.app/profile/us-g...

Definitely a built-in feature, just can’t find where they live in the app after subscribing to them…

I have no clue how to find and share it with you, but there’s a thing called a “Labeler” that overlays profiles with annotations. For example I found one that overlays politicians’ profiles/posts with tags of who donates to their campaigns (from OpenSecrets).

Very neat idea

Arguably best case scenario is shit hits the fan *quickly*

People seem to have trouble comprehending change over long periods

Though I guess that’s banking on widespread disease not being pinned on 5G towers or something…

Nothing surprising here: despite Congress having very low approval ratings, people tend to love *their* representatives.

Congresspeople don’t attract nearly the same spray-and-pray disgruntlement that POTUS does.

People who are saying “oh insurance companies are awful” should do some deeper research into UHG, and in particular into the playbook they run as a “pay-vider.”

It’s actually way, way worse than you thought!

So I'm finally allowed to tell you about what I've been working on for the past year: It's called Offcall.

It's built by physicians for physicians, and we're starting with one of the biggest problems we've heard amongst physicians: salary and workplace transparency.

Well we already *do* pay massive amounts of money into this stuff, as OP mentioned. It’s just much earlier in the supply chain.

NIH gives out like $38 billion in grants annually. We can spur thousands of drug programs that way, or try to put ~50 drugs through trials w/ 80%+ failure rate

A problem in one place is not a good justification to replicate it someplace else!

Not sure I’d agree the space program is similar. It was obviously POSSIBLE to get to space with enough money, and it was pretty well-understood how much it’d take. Not so with drugs. A true lottery.

Totally agree there are other risks besides financial, I’m saying the financial risk profile alone makes it pretty untenable for government to take it on.

To be clear, not b/c they wouldn’t be able to sustain losses, but b/c it’d require doling out massive amounts of 100% unaccountable money.

The vast majority of the cost and risk of drug development is incurred by clinical trials (not pre-clinical work like what’s discussed here).

However, it’d be great if royalties on commercialized products were paid back to grant-funding agencies like NIH!

Better idea maybe but totally impractical. You’re talking about the government trying to select likely-winners and handing them *billion dollar budgets* to launch one of the most complex business processes in existence.

It’s just not something govt is well-suited for. That risk should be privatized

This Thanksgiving, you should consider establishing a codeword amongst your family members to verify your identities over the phone.

It takes <$1 and <3 minutes of audio to convincingly clone your voice into an AI model that can be used by “vishers” (voice phishers) to scam your loved ones 🙂

Just in time for the raw milk revolution!

IMO people do two things:

1. fail to recognize the impact of emotional state on cognition

2. fail to recognize the sources of their emotional state

So yes, if crypto goes up, good feeling, therefore economy more better

Science is so hard because it’s hard to counteract such heuristics

Plz no

Yes he’s talking about dismissing Congress to force cabinet appointees through, but my BTC is up $6,000 total over the past 6 years so have fun staying poor 😂😂🤣

Potential Lives Saved Through Widespread Global Availability of GLP-1 Receptor Agonists: A Modeling Study This model attempts to quantify the potential impact of GLP-1 receptor agonists (GLP-1) in reducing global mortality linked to obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD...

How many lives could be saved through global access to GLP1 receptor agonists? We estimate almost 1 million lives a year.

More 👇🏻
www.medrxiv.org/content/10.1...

Perhaps biotechs should be allowed to conduct clinical trials on the basis of well-wishes and good vibes!

Yep exactly! I've had so many people tell me "FDA should allow challenge trials or Exotic Trial Design X Y Z" and I'm like... they do?

The reason people don't is because it's very hard to prove anything with them!