Daniel Fisch

A headline: Scientists have discovered a 'third state' between life and death

"Postdoc in the job market"

Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1

DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....

Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.

🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!

With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇

Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3. Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...

We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!

What's in yer basement?

📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...

Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
www.biorxiv.org/content/10.1...

Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

Thrilled to share my work from the @jkagan1.bsky.social lab!

TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!

www.biorxiv.org/content/10.1...

#microsky #immunosky

Real-time visualization of STAT activation in live cells using genetically encoded biosensors - Nature Chemical Biology The signal transducer and activator of transcription (STAT) family proteins are attractive drug targets but tools to monitor their activation are lacking. Now, STAT biosensors have been developed for ...

Tools:
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Guilty as charged.

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...

Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...

Oxidized phospholipid damage signals as modulators of immunity | Open Biology Damage-associated molecular patterns (DAMPs) are self-derived molecules released during tissue damage that influence immune responses. Phospholipids, essential to cell membranes and lung surfactants, ...

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...

Zotero has changed my life for the better. What a marvelous piece of software.

MyD88 polymerization and association to cellular membranes in a yeast heterologous model - Cellular and Molecular Life Sciences MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs). Structurally, MyD88 consists...

MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...

Fantastic three days of science at #HFSPmtg25! Thank you @hfspo.bsky.social for hosting us in Melbourne!

🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)

Sign of the University of Queensland, Brisbane

Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!

Sunset over Heidelberg, Germany

Poster session in the EMBL ATC Building

Thank you @embo.org for a fantastic Fellows’ Meeting 2025. So much amazing science and brilliant young scientists gathered in one place really gives back hope for the future of biomedical research! 🔬🧪

Congratulations!!!

A huge thank you to @cibss.bsky.social and @uni-freiburg.de for hosting me today on my visit back to where my science journey started! What a fun day filled with great scientific discussions 😁

Sharepic with date, time, title of Dr. Daniel Fisch's CIBSS seminar on "Microbial Sensing in Innate Immunity", Tue, June 24, 2025 , 12:00–13:00 at the Inst. of Biology I, Hauptstr. 1 + livestream

Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!

📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream

More info: kurzlinks.de/y41k

Fantastic work by the Coers lab! GVIN1 (finally) joins the club of antimicrobial GTPases.

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.

We report today that the structurally complex PAMP LPS can be broken down to a simple pattern that is detected by the innate immune receptor caspase-11. This pattern is a lipid containing a negative charged headgroup + acyl chain ≥14 carbons.
www.science.org/doi/10.1126/...