Heidi Creighton

From sequence to function: Bridging single-molecule kinetics and molecular diversity Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...

🧬Appearing today @science.org a Review - From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science 🔬https://www.science.org/doi/10.1126/science.adv4503

Spatial Biology Update - DeciBio is developing a new report focused on the real-world perspectives of end users of spatial omics technologies. For more information, contact Rebecca Burnham, PhD #spatialbiology #spatialomics #singlecell #multiomics

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The new cover and feature @nature.com www.nature.com/immersive/d4...

Presenting data from the largest integrated thyroid cancer single-cell sequencing atlas

@vivianweiss.bsky.social et al. highlight stromal tumor-dynamics occurring across the spatial evolution of thyroid cancer from indolent to lethal disease: doi.org/10.1172/jci....

Systems Biology: Global Regulation of Gene Expression Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Interested in cutting-edge work in both the development and application of techniques to better understand gene regulation from a systems perspective? Abstract submissions are still open for this CSHL meeting: meetings.cshl.edu/meetings.asp...

Join the LinkedIn Group "Spatial Biology Pioneers" if you are in the spatial multiomics field #spatialomics #singlecell #multiomics linkedin.com/groups/13906...

Spatial Multi-omics

DBiTplus
DBiT-seq + CODEX

Mesmer segmentation
MaxFus multiomic integration
CODEX-informed spatial deconvolution (TACCO vs Cell2location vs RCTD)

Work on FFPE
>1000 genes/25 μm spot

@zongmingma.bsky.social @rongfan8.bsky.social #NatMethods 2025
www.nature.com/articles/s41...

In this episode of the Epigenetics Podcast, we talked with Will Wang from @sbpdiscovery.bsky.social about his work on muscle stem cell repair, regeneration, and aging, exploring spatial-omics and machine learning. #podcast #epigenetics

Listen here: activemotif.com/podcasts-wil...

Making progress on global health will need high-quality evidence Nature Health, the newest journal in the Nature Portfolio, aims to bridge the ‘implementation gap’ from research to policy and practice.

Nature Health, the newest journal in the Nature Portfolio, aims to bridge the ‘implementation gap’ from research to policy and practice

go.nature.com/49Jmm1J

Integration of imaging-based and sequencing-based spatial omics mapping on the same tissue section via DBiTplus - Nature Methods DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiple...

www.nature.com/articles/s41... @nature.com

Single-cell and spatial profiling highlights #TB-induced myofibroblasts as drivers of lung pathology. From Ian Mbano, Nuo Liu, Paul Elkington @unisouthampton.bsky.social, Alex Shalek @mit.edu, Alasdair Leslie (Africa Health Research Institute) et al: rupress.org/jem/article/...

#Tuberculosis

The cover shows in situ spatial transcriptomics on brain and tumor tissues from a diffuse midline glioma (DMG) xenograft mouse to identify tumor and infiltrating immune cells.

A large patient study suggests that testing for tau protein in blood can predict post-stroke outcomes, an antibody cocktail shields rodents from RSV while preventing viral escape, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3YHiUQ2

Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue Jalkanen et al. generate spatial and single-nucleus transcriptomic maps of human subcutaneous and visceral white adipose depots, revealing distinct cytoarchitectural and immunologic features. Epiploic...

A single cell and spatial profile of visceral and colonic adipose tissue www.cell.com/cell-metabol...

Researchers uncover molecular roots of fibrosis or tissue scarring in inflammatory bowel disease New study finds a biological pathway responsible for dangerous scarring, which could possibly be targeted by new treatments.

Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.

The Single-Cell Club Is Rapidly Expanding As single-cell RNA-Seq meets AI, and DNA sequencing prices drop, projects are becoming much (much) larger.

“We’re at a point,” Sarah Teichmann continued, “where we can start to assemble the data sets and provide reference atlases for different tissues, different organs, different systems around the body.”
www.genengnews.com/topics/omics...

The MICrONS Project An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses. This integrated view of function and structure lays a foundation for discovering the computational bases of cortical circuits.

This project is an unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses

https://go.nature.com/3YnGotC

Thanks so much to @ddiamond.bsky.social for his excellent, detailed coverage of how medical research is being harmed by federal instability. We need to keep talking about this and help the public understand the scope of damage that is happening and how this will impact future medicine and technology

🔔 Save the date!
Join us for the next IICD Seminar on April 9 at 2 PM ET with Jean Fan @jef.works from @jhu.edu

🔬 Multi-Sample Comparative Spatial Omics Data Analysis
📍 In person: Schermerhorn 603
💻 Remote: Register 👉 bit.ly/4j0RwEM

graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

Perturb-FISH, a method that combines high-throughput imaging spatial transcriptomics with in situ guide RNA detection, allows for the analysis of molecular and functional states, with spatial resolution at the single-cell level @cellcellpress.bsky.social
www.cell.com/cell/fulltex...

Liver cancer recurrence predicted by immune-cell location and gene expression Immune cells called natural killer cells can target and eliminate tumours. The gene expression and spatial distribution of the immune cells in the tumour microenvironment indicates whether liver cance...

Cancer recurrence predicted by spatial biology of the immune response nature.com/articles/d41...
nature.com/articles/s41...

Join @jlemieux.bsky.social and expert panelists -- Catharine Aquino @biomath.bsky.social @jasmineplummer.bsky.social @jessie-no.bsky.social -- as they cover the latest research and novel technologies. #genomics #NGS #spatial #singlecell #AGBTGM #AGBT25 REGISTER: hubs.li/Q036f_3x0

Celebrating All Women in Science this weekend! 🎉🔬🧬#WomeninScience #February11 #WomenAndGirlsInScience #WomenInSTEM #IDWGS #IDWGS2024 #WomenInScienceDay @bsky.app Learn more at www.un.org/en/observanc...