Lara Labarta-Bajo, PhD

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems

Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems www.nytimes.com/2025/10/06/h...

The courts aren’t falling for Trump’s chaos

They’ve blocked him 200+ times, including when trying to deploy the Nat’l Guard to Portland w/ no emergency on the ground

At @democracydefendersfund.org we’ve led 150+ legal actions to stop this lawless power grab

I explain on @velshimsnbc.bsky.social👇

🔬 New preprint out!

Thrilled to share our new preprint, where we uncover the molecular diversity and developmental origins of cerebellar astrocytes using multi-omic approaches.

📄 www.biorxiv.org/content/10.1...

#scRNAseq #astrocytes #neuroscience #glia #cerebellum @biorxiv-neursci.bsky.social

New Member Lara Labarta Bajo, PhD, The Salk Institute for Biological Studies, La Jolla, CA, USA - Biweekly newsletter of the International Cytokine & Interferon Society Lara Labarta Bajo, PhD, is a postdoc in Nicola Allen's lab at the Salk Institute, studying the crosstalk between astrocytes and the immune system and its implications for synapses during healthy aging.

I am thrilled to be attending Cytokines2025. See you in beautiful Seattle @cytokinesociety.bsky.social signals.cytokinesociety.org/2025/06/30/n...

Repost if you're planning to go.

www.pnas.org/doi/10.1073/... @trevergreene.bsky.social

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice - Nature Communications Cerebellar ataxia, a hallmark of cerebellar degeneration (CBND), is driven by mitochondrial dysfunction in Purkinje cells. In this study, transplanting mitochondria into CBND mice improve mitochondria...

Mitochondria transplantation transiently rescues cerebellar neurodegeneration improving mitochondrial function and reducing mitophagy in mice www.nature.com/articles/s41...

I'll be talking about some of this at the rally at UCSD tomorrow, thanks for having me!

Very interesting review by @neuronoeker.bsky.social et al aging-longevity.org.ua/journal-desc...

Important reference for anyone planning to Stand Up for Science this week.

Looks like tomorrow will bring votes on a Republican plan to fund tax cuts for the rich by slashing Medicaid.

So this is a great time to contact your Member of Congress.

Is science in danger? Podcast Episode · Today, Explained · 02/17/2025 · 25m

podcasts.apple.com/us/podcast/t...

Thank you @thetransmitter.bsky.social for bringing attention to this.

Yes

JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants.

storage.courtlistener.com/recap/gov.us...

Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

USA Capitol Switchboard
(202) 224-3121 #resist

In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313 Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…

🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇

sciencedirect.com/science/arti...

New: Amir Ferry, Ananda Goldrath and colleagues @ucsdhealthsci.bsky.social show that differentiation of tissue-resident memory T cells (TRM) is accompanied by the upregulation of the conventional DC1 (cDC1) chemoattractant, Xcl1. https://buff.ly/4hrKCYe

#MucosalImmunology #TumorImmunology

How do T cells find the proper instructions to navigate tissues? In the Goldrath Lab @ucsdhealthsci.bsky.social, Amir Ferry mapped it out play-by-play. Potentiating these interactions strengthens the immunity cycle and enhances tumor control 1/n

Spatial omics rides again, this time determining how immune CD8 T cells by location in the gut have different roles, such as killing function in the villus and backup reinforcements in the crypts
www.nature.com/articles/s41...
Good Explainer www.lji.org/news-events/...
@alleninstitute.bsky.social

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

Today in @nature.com. We mapped the spatial and temporal dynamics of intestinal tissue-resident memory CD8 T (TRM) cell differentiation.
🔗 www.nature.com/articles/s41....
@ucsandiego.bsky.social @lji.org @alleninstitute.bsky.social @amonell.bsky.social @reinacampos.bsky.social @GoldrathLab 🧵 1/10

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

Beautiful study by @reinacampos.bsky.social @amonell.bsky.social @heeg.io Ananda Goldrath on the temporal and anatomical organization of Tcell memory. Tour de force spatial transcriptomics, computational methods, in vivo perturbation, spatial regulators and much more. www.nature.com/articles/s41...

Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted - Nature Profiling of the location and transcriptome of tissue-resident memory CD8 T cell formation at single-transcript resolution finds regionalized signalling as the basis of immune diversity in t...

It turns out the immune system is playing 4D chess while we thought it was just playing checkers. Using #spatialtranscriptomics from @10xgenomics.bsky.social and @vizgen.bsky.social we were able to peek into the secret lives of tissue resident T cells in the gut as they form after infection 1/n

🚨 Revolutionising Snakebite Treatments with AI-Designed Proteins 🐍

I'm proud to share our latest study published in hashtag#Nature, driven by Susana Vazquez Torres, and co-led by David Baker (Institute for Protein Design, University of Washington) and myself.

Beyond classical immunity: Mast cells as signal converters between tissues and neurons Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can prevent...

'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.'
#Immunology #Neuroimmunology

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP
www.science.org/doi/10.1126/...