Protein language models can predict epistasis (non-additivity of multiple point mutations) if predictions are nonlinearly transformed first www.biorxiv.org/content/10.1...
19.09.2025 11:20 โ ๐ 15 ๐ 2 ๐ฌ 0 ๐ 1
Protein Language Models Capture Structural and Functional Epistasis in a Zero-Shot Setting https://www.biorxiv.org/content/10.1101/2025.09.14.676130v1
17.09.2025 23:47 โ ๐ 1 ๐ 1 ๐ฌ 0 ๐ 0
We were wondering: Do protein language models learn epistatic signals during pretraining?
Turns out, yes!
Protein Language Models Capture Structural and Functional Epistasis in a Zero-Shot Setting
www.biorxiv.org/content/10.1...
18.09.2025 00:01 โ ๐ 5 ๐ 2 ๐ฌ 0 ๐ 0
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