Doris Kaltenecker

Such a great study, combining tissue clearing, imaging and scRNA-Seq 👏🏼

A graphic announcing the 2025 grant recipients of the EFSD/Novo Nordisk A/S Programme for Diabetes Research in Europe. The top of the image has a white text box with the program title in bold navy-blue letters. Below, “2025 Grant Recipients” is centred in white text on a green and teal geometric background. The recipients’ names, affiliations, and countries are listed in two rows: Top row: Hannele Yki-Järvinen, University of Helsinki, Finland, Maike Sander, Max Delbrück Center for Molecular Medicine, Germany, Amandine Gautier-Stein, University of Lyon, France Bottom row: Doris Kaltenecker, Helmholtz Munich, Germany, José Javier Fuster-Ortuño, National Center for Cardiovascular Research, Spain, Inga Prokopenko, University of Surrey, United Kingdom The EFSD logo appears in the bottom left corner, and the website “europeandiabetesfoundation.org” is shown at the bottom right on a light blue band. The design features overlapping blue and green shapes with circular accents in the top right

Congrats to the 2025 #EFSD/@novonordisk.bsky.social A/S Programme for #DiabetesResearch in 🇪🇺 #grant recipients!🏆👏

Driving innovation across 🇪🇺 to advance knowledge & treatments for #diabetes.

Excited to see the impact of your research 👉 www.europeandiabetesfoundation.org/recipients/e...

#Funding

We are introducing LipiGo 🤗
A programmable DNA–lipid nanocarrier 🧬 with built-in targeting logic. It de-targets the liver and redirects mRNA delivery into lymphoid organs, enhancing therapies requiring the immune system. Precision delivery at the cell level isn't far! www.biorxiv.org/content/10.1...

How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are?

In our recent paper we find that indeed, they are! Read the skeetorial below ⬇️⬇️⬇️

plos.io/4mq5tOy
#neuroscience #neuroskyence #whitematter #deeplearning

Sure, Would be cool! I’m there pretty frequently.

Congratulations Jason 👏🏼😀

Big thanks to Søren Fisker Schmidt, Stephan Herzig, Mauricio Berriel Diaz and all co-authors for making this possible 🫶🏻

@www.helmholtz-munich.de @diabresearch-dzd.bsky.social @tum.de
@cellpress.bsky.social

Excited to share that our study on the role of the liver in #CancerCachexia is out in Cell! 😀 🧬

We found that the liver plays an active role in driving weight loss in cancer through disruption of the circadian regulator REV-ERBα and secretion of catabolic hepatokines

www.cell.com/cell/fulltex...

Researchers have identified a previously overlooked driver of cachexia: the liver.

🔬 New study: The #liver plays an active role in cancer #cachexia via silenced clock gene REV-ERBα. Key step toward new therapies.

👉 Read more: t1p.de/eh136

@tum.de @diabresearch-dzd.bsky.social @dorie00.bsky.social ky.social #CancerResearch #Cachexia #Liver

A neuroimmune circuit mediates cancer cachexia-associated apathy Cachexia, a severe wasting syndrome associated with inflammatory conditions, often leads to multiorgan failure and death. Patients with cachexia experience extreme fatigue, apathy, and clinical depres...

1/ Why do patients with late-stage cancer lose motivation & sink into apathy?
🔥 Our new Science paper shows chronic inflammation activates a cytokine-sensing brain circuit that lowers motivation. Huge team effort: Aelita Zhu, Sarah Starosta, Pignatelli & Janowitz labs! 🧵
🔗 doi.org/10.1126/scie...

See our recent @naturebiotech.bsky.social study SCP-Nano in flow! Mapping LNPs, AAVs, and DNA nanostructures to track targeting & unseen toxicity before clinical trials 🤩. Already >190K access, the most in recent years! 👇🏼 www.nature.com/articles/s41...

Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex We find that the right and left auditory cortex in mice are both organised in cortical columns, with asymmetric myelination in the different layers and differences between the sexes. In addition, the...

As of today, the main finding of my PhD is published in the European Journal for Neuroscience! 🥳🥳

Together with Gesine Müller, we looked at hemispheric asymmetries in the mouse auditory cortex. We find layer, sex, and hemispheric differences: doi.org/10.1111/ejn....

🧵

Twitter:
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we developed SCP-Nano: an AI and tissue-clearing-based technology for precision nanotechnology. www.nature.com/articles/s41...

I am looking for a #PhD working on this exciting project! In case you are interested in how #immunometabolism and #macrophages affect #adipose tissue function, check the link below and apply! www.immunometabolism.at/job-openings/

How does obesity reshape peripheral nerves and immune cells at the whole-body level? 🌟 Our preprint explores this using an AI-driven pipeline to precisely identify, map, and quantify these changes. Thrilled to share it with you here on BlueSky! 🦋😀
www.biorxiv.org/content/10.1...

Our new study shows that SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it🔬🧠🦠🧵Your weekend read👇
@cellpress.bsky.social
cell.com/cell-host-mi...

The SARS-CoV-2 spike protein can persist in the brain—in the skull bone marrow and meninges—to induce neurologic damage
www.cell.com/cell-host-mi... open-access

Yes 😀 but there wasn’t much going on Bluesky back then 😅

Science Magazine on LinkedIn: This light-sheet microscopy three-dimensional rendering shows a… This light-sheet microscopy three-dimensional rendering shows a first-of-its-kind mouse whole-brain mRNA analysis at single-cell resolution. Learn more in…

Thrilled to announce that our latest work has been published in Science and featured on the front cover!

www.linkedin.com/posts/scienc...

Hey Bluesky! As Erturklab, we are also moving to alternative social media 😉. Stay in touch to follow our work on AI and tissue clearing driven cell-level imaging of intact mouse bodies and human organs, and how we use these methods to study diseases and develop therapeutics at the cellular level.

And our lab is here, too, now.

@erturklab.bsky.social

Stay tuned ...

bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...

Hello Bluesky 🙋🏼‍♀️