CondeNanoLab

How to de-Americanize global science The US science crisis presents an opportunity to reinvent funding and management of the global research enterprise.

The US science crisis presents an opportunity to reinvent funding and management of the global research enterprise, says João Conde

go.nature.com/3UdHeGP

🚨 Out now in @nature.com: it's time to de-Americanize global science. We need:🌍 Equitable funding 🔄 Shared governance 🔐 Resilient data infra🆘 Emergency support for scientists at risk. The next crisis can’t break global research again. Nova Medical School
🔗 rdcu.be/ewp6K

🌍 World Cancer Day 2024: uniting for a future without cancer 🎗️Today we are reminded of our shared responsibility to fight cancer through awareness, innovation, and collaboration. What role will you play in the fight against cancer? Let’s raise awareness💙 Nova Medical School

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202412757?af=R

Look what I just found. My @mitofficial.bsky.social MIT card 😅 miss it so much 😍

Figure: Change in life expectancy attributable to leading causes of death in 1990–2021 for the USA and among US states and Washington, DC. Copyright: 2024 The Author(s). Published by Elsevier Ltd. CC BY 4.0.

The burden of disease in the USA has evolved over the past three decades.

A recent study examines the burden of diseases, injuries, and risk factors in the USA and highlights the disparities in health outcomes across different states: tinyurl.com/5nsdjbht @ihmeuw.bsky.social

Happy to see our 2 articles #GBDstudy published at @thelancet.bsky.social and on the cover of the journal about a special issue on USA Health: diseases, injuries, and risk factors 1990–2021

www.thelancet.com/issue/S0140-...

NOVA Medical School, @ihmeuw.bsky.social

Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers - Nature We evaluate the effects in humans of interleukin-15 co-expression on glypican-3 (GPC3) chimeric antigen receptor (CAR) T cells and demonstrate that IL-15 increases the expansion, intratumoural su...

new out in Nature www.nature.com/articles/s41...

Covers of Science and Nature journals in the past 2 weeks denoting remarkable progress of life science with A.I. tools

A vertical takeoff of life science with #AI LLLMs.
Publication of 10 new foundation models of Proteins, DNA, RNA, methylation, cells, and interactions, evolution, and design in the past couple of weeks!
Unprecedented progress, reviewed in the new Ground Truths
erictopol.substack.com/p/learning-t...

Brain-penetrating molecule might offer a route to treat glioblastoma tumours Molecule targeting brain tumours disrupts nucleotide production.

and the News & Views
www.nature.com/articles/d41...

Designer RNA condensates The cover shows a fluorescence microscopy image of synthetic cells expressing artificial organelles, assembled from genetically encoded RNA nanostructures.   See Fabrini, G., Farag, N., Nuccio, S.P. et al. Co-transcriptional production of programmable RNA condensates and synthetic organelles. Nat. Nanotechnol. 19, 1665–1673 (2024). https://doi.org/10.1038/s41565-024-01726-x Abstract Condensation of RNA and proteins is central to cellular functions, and the ability to program it would be valuable in synthetic biology and synthetic cell science. Here we introduce a modular platform for engineering synthetic RNA condensates from tailor-made, branched RNA nanostructures that fold and assemble co-transcriptionally. Up to three orthogonal condensates can form simultaneously and selectively accumulate fluorophores through embedded fluorescent light-up aptamers. The RNA condensates can be expressed within synthetic cells to produce membrane-less organelles with a controlled number and relative size, and showing the ability to capture proteins using selective protein-binding aptamers. The affinity between otherwise orthogonal nanostructures can be modulated by introducing dedicated linker constructs, enabling the production of bi-phasic RNA condensates with a prescribed degree of interphase mixing and diverse morphologies. The in situ expression of programmable RNA condensates could underpin the spatial organization of functionalities in both biological and synthetic cells.   Image: Giacomo Fabrini (The Francis Crick Institute) and Lorenzo Di Michele (University of Cambridge). Cover design: Vanitha Selvarajan

🤩 November 2024 issue of @naturenano.bsky.social is here 👉 www.nature.com/nnano/volume...

The cover shows synthetic cells expressing artificial organelles, assembled from genetically encoded RNA nanostructures @dimichelelab1.bsky.social

Paper here 👉 doi.org/10.1038/s415...

#FluorescenceFriday

#proudPI Check out the amazing #Nanomedicine Team 2024 🏆🥇 and our Lab website 👉 www.conde-nanolab.com ...stay tuned… at Nova Medical School ... thank you so much for your amazing work everyday ☺️🙏