Gregor Rot 🌈

TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD - PubMed Motor neuron hyperexcitability is a broadly observed yet poorly understood feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Nuclear depletion and cytoplasmic aggregation...

Hot off the press from the RTI: TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD
buff.ly/X23QYQI #RNA #RNATherapeutics

Zurich government rejects proposal to take in Gaza children

www.swissinfo.ch/eng/foreign-...

UBS bank posts $2.5 billion Q3 profit

www.swissinfo.ch/eng/various/...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

#RNAsky #SpatialGeneExpression
share.google/OuxQ2j5N1phh...

TDP-43 loss brings RNA to a twist ending - Nature Neuroscience In amyotrophic lateral sclerosis (ALS), nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 cause widespread dysregulation of mRNA splicing. Two recent studies have now rev...

Exciting month for the study of TDP-43 in neurodegenerative disease and alternative polyadenylation (APA).

Overview of 2 new studies published in Nature Neuroscience by Bryce-Smith et al. and Zeng et al.:

www.nature.com/articles/s41...

I spent a romantic Wednesday evening with Javascript figuring out attaching code via "a href" for disappearing / appearing elements on mobile is not a good idea. Charming!

But now also "x" on the search field works on mobile for pubscan.expressrna.org :-)

Ready to start your own independent research programme?

We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk

Apply by 27 Nov 2025:
www.crick.ac.uk/careers-stud...

#EarlyCareerResearchers #GroupLeader #ScienceCareers

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.

Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.

Apply now ➡️ www.crick.ac.uk/careers-stud...

Thanks Martin!

#pubscan mobile ready now @metagenomez.bsky.social 👍

🚀 pubScan v2 is live!

What’s new:

📱 Mobile-friendly design
⚡ 5x faster thanks to our new SQLite backend
🛠️ Fully open source

Dive into your co-authorship network today:
🔗 pubscan.expressrna.org

Like it? Share and repost :-)
#pubscan #coauthorship #network #bioinformatics

Promotional image with the text 'Can We Cure Cancer?' showing four panellists on the left and a host speaking into a microphone on the right against a colourful background.

NEW EPISODE: Can we cure cancer?

Join our expert panellists as they answer audience questions about the future of cancer research and treatment.

Listen on your favourite podcast platform:
lnk.to/AQOSCancerBB

A transcriptional map of human tonsil architecture: beyond the sum of (single cell) parts The tonsil is a highly compartmentalized organ in which different microanatomical structures orchestrate designated (immune) functions. We use this already well-studied tissue to survey spatial molecu...

🚀 Spatial Transcriptomics (Imaging) + Spatial-centric analyses by @helucro.bsky.social : the way to truly interrogate tissues!!!
📖 Read our pre-print on human tonsil architecture (full of tonsiLove ♥️) here: doi.org/10.1101/2025...

Israel has committed genocide in Gaza, says UN inquiry Commission’s 72-page legal analysis cites examples including scale of killings, aid blockages and forced displacement

A UN commission of inquiry concluded on Tuesday that Israel had committed genocide in Gaza and that top Israeli officials including the prime minister, Benjamin Netanyahu, had incited these acts.

www.theguardian.com/world/2025/s...

Universities around the world cut ties with Israeli academia over Gaza war Educational bodies from Europe to South America are boycotting Israeli institutions, though Universities UK said it did not support the action

Universities around the world cut ties with Israeli academia over Gaza war

www.theguardian.com/world/2025/s...

📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...

CBIAS napari workshop 2025

Want to enhance your image analysis skills with napari?

We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data.

🕒 Applications close on 15 September.

Learn more and apply 👇

www.crick.ac.uk/whats-on/cbi...

The power of RNA sequencing in molecular oncology. #RNAseq #MolecularOncology Genomics @natmed.nature.com 🧬
www.nature.com/articles/s41...

MoGAAAP: A modular Snakemake workflow for automated genome assembly and annotation with quality assessment. #GenomeAssembly #GenomeAnnotation #GenomeQuality #Genomics #Bioinformatics @biorxiv-bioinfo.bsky.social 🧬 🖥️
www.biorxiv.org/content/10.1...

Beautiful app.flow.bio #flowbio web-app and Nextflow backend, this is how web-dev should be done in life sciences, very nice!

A spatial long-read approach at near-single-cell resolution reveals developmental regulation of splicing and polyadenylation sites in distinct cortical layers and cell types. #LongReads #SingleCell #Spatialtranscriptomics #IsoSeq #PolyA @natcomms.nature.com
www.nature.com/articles/s41...

YouTube video by Michele Cioffi Umberto Galimberti - La Bellezza. Legge segreta della vita - ASI CULTURA 26/07/2025 VILLAESTATE

Galimberti: La Bellezza

www.youtube.com/watch?v=I0cN...

The natural diversity of E. coli transporter-dependent capsules Serotyping of bacteria using genomic information ( in silico serotyping) has increasingly replaced serology. However, the E. coli capsule serotyping system has been largely abandoned since the 1990s, ...

How diverse are E. coli capsules? How are they linked to ecology and disease? Find out with > 25,000 genomes and MAGs including undersampled environments and hosts from all over the world.
Great genomics - glycobiology synergy in Sunagawa and Slack groups at ETH!
www.biorxiv.org/content/10.1...
🧪🧫🔬

Widespread 3′ UTR splicing regulates expression of oncogene transcripts through multiple mechanisms. #3UTRsplicing #TranscriptRegulation #Genomics @narjournal.bsky.social
academic.oup.com/nar/article/...

"my garden

in the sun and in the rain
and in the day and in the night

pain is a flower
pain is flowers

blooming all the time."

- Charles Bukowski

The MicrobeAtlas database: Global trends and insights into Earth's microbial ecosystems Environmental DNA sequencing has revolutionized our understanding of microbial diversity and ecology. Microbiomes have now been sequenced across the entire planet - from the deep subsurface to the mou...

Congrats everyone, such a tour de force!

"The MicrobeAtlas database: Global trends and insights into Earth's microbial ecosystems"

www.biorxiv.org/content/10.1...

YouTube video by Klemen Selakovic – AIDEA podkast Stanford, start-upi in moč podatkov (dr. Jure Leskovec) – AIDEA 187

Jure Leskovec

www.youtube.com/watch?v=UmE7...

#voltaire

#charlesbukowski #weevolve

YouTube video by Videoteca Umberto Galimberti LA VITA È INCERTA - #Galimberti (Conferenza 2024 "Ragione e Follia) #filosofia #crescitapersonale

Incredible Galimberti, incredible. Amazing.

www.youtube.com/watch?v=UIcE...

Noam Chomsky