Dan Tyrrell

Is that a ghost?

Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus The ventromedial hypothalamus (VMH) and arcuate (ARC) nuclei of the hypothalamus play critical roles in regulating metabolism and behavior. Here, Mulvey et al. create a focused spatial transcriptomic ...

Now online! @lieberinstitute.bsky.social & @jhubiostat.bsky.social collaboration generating important resource (Visium & Xenium) on molecular organization of human hypothalamus w/ cool findings associating sex differential expression to neuropsychiatric disorders 🧠🔬🧪
www.cell.com/cell-reports...

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases - Nature Immunology Nature Immunology - Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases

Clonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases.

Great paper on CD8 T cells, T cells, and inflammation from Elyaman lab

doi.org/10.1038/s415...

Parkinson’s may originate in the enteric nervous system, via muscularis macrophages containing misfolded α-synuclein that develop endolysosomal dysfunction & promote T cell expand/traffic to brain
www.nature.com/articles/s41... @nature.com @soyonhonglab.bsky.social @ucl.ac.uk @cmn-vib.bsky.social

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience The choroid plexus is a vital brain ventricular organ that produces cerebrospinal fluid. This study shows how developmental origins and local niches shape the specialization of choroid plexus macropha...

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins.

if you like the choroid plexus and macrophages, you will probably like this paper

doi.org/10.1038/s415...

Establishing the relationship between brain cellular senescence and brain structure.

Another pretty slick paper on microglia, aging, and senescence

doi.org/10.1016/j.ce...

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

Aging promotes microglial accumulation of slow-degrading synaptic proteins.

Nice paper on microglia from Tony Wyss-Coray's group

doi.org/10.1038/s415...

Clonally expanded tissue-resident CD8+ T cells within the leptomeninges of individuals with neurodegenerative diseases
www.nature.com/articles/s41... @natimmunol.nature.com www.nature.com/articles/s41...
@columbiauniversity.bsky.social

Past, present and future perspectives on the science of aging - Nature Aging As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related diseas...

Past, present and future perspectives on the science of aging. they didn't ask for my perspective but still interesting I guess
doi.org/10.1038/s435...

Cell cycle arrest enhances CD8+ T cell effector function by potentiating glucose metabolism and IL-2 signaling - Nature Immunology Here the authors show that transient cell cycle arrest reprograms CD8+ T cells into a highly energized state, increasing proliferation and antitumor activity and boosting efficacy of immunotherapies i...

Great paper on CD8 T cells, T cells, and immunity
doi.org/10.1038/s415...

No, it is the Axis of Peace. We’re the good guys because we say we are

Watching the CFP with my 8-yo son and #67 gets a penalty. Brah went wild

Ah yes! I loved my 87 CRX. Drove from MI to NC for grad school in that thing. I think I clocked 62 mpg once. I guess that’s what you get when the car has no AC, no safety features, 2 seats, and only slightly larger than a golf cart. Super fun car though! I wish I still had it

8 were invited lol. not sure the editor expected to get so many to accept. gonna be 'fun'

I took my baby to get vaccinated yesterday. Is the gov’t gonna get me??

boss move

reviewers 1-6 agreed to review our paper

🫣

Congrats!!!

ChoreDash, where you pay someone to do stuff you don’t want to do

Me too. Into my sweatpants 💪 persevere!

AD has been “cured” or “reversed” in mouse models of AD before. Doesnt translate well to human ever (so far)

Christmas is over. now approaching the gauntlet - Valentines day, anniversary, birthday, mother's day

Review @jem.org
T cell engagers emerge as a compelling therapeutic modality
rupress.org/jem/article/...

Got my own Christmas story thing going on. Kid shot himself point blank in the eye with a nerf gun so we’re here at the eye ER. you’ll shoot your eye out kid

TGFβ Angiogenesis

Endothelial Cell TGFBR1/2 KO🐭
Retina
👉⏬Angiogenesis into intermediate/deeper vascular plexus
👉Widespread vascular tufts
👉Ectopic αSMA+/NG2+ mural cell
👉Spontaneous choroid neovascularization
👉EC inflamm
👉Extensive immune cell infiltr

#eLife 2025
elifesciences.org/articles/107...

Alabama public school ranking

My kid just said the thumb is not a finger. 🧐

apparently the summer semester is just called "Summer". Missed opportunity IMO

Sewanee university calls their semesters "Advent Semester" and "Easter Semester"

Henry VIII had a gold chain that said “I prefer to die rather than change my mind” and I love that!! Loool

First invest heavily in Hep A and if you treat it right, it will evolve into Hep B. No shortcuts