Sofiya Hupalo

Very cool, congrats!!!

Could you share publication(s) supporting the antidepressant actions of 5HT2A receptor antagonists in humans (statement #3)?

Happy to see this conversation happening. As someone who withdrew from their 1st attempt at PhD due to mental health, way back in the mid-90's, it was very difficult to overcome that obstacle when applying to PhD programs again. I was always seen as a risk...even after completing a masters degree.

Diversity supplements weren’t just for folks from underrepresented racial/ethnic backgrounds. Eligibility extended to first gen college students and researchers with disabilities, among others

Cancelling these supplements limits opportunities for the next generation of scientists, as explained here

Recapping the #ACNP2026 study group, “Centering Lived Experience in Psychiatric Neuroscience Research”

We asked the panelists, what could NIH leadership do to be more supportive of trainees with non-traditional career paths, which is common among researchers with lived experience of mental illness?

Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions Full Committee Hearing on February 3, 2026 at 5:00 AM

I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee.

Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here:
www.help.senate.gov/hearings/mod...

Excellent, I didn’t see it come out, thanks for sharing 😁

Absolutely! I have been meaning to revisit this poster in the ACNP portal, there was lots of good data in there !

A huge thank you to Dave Kupferschmidt — my co-first author — who continued the momentum on this project after I left the Gordon Lab and shepherded it to the finish line ✨

We observed that SETD1A haploinsufficiency disrupts beta (and to lesser extent gamma) synchrony between the PFC and thalamic nucleus reuniens during working memory performance. Unlike some other SCZ genetic risk models, we did not observe broader hippocampal–prefrontal synchrony deficits.

Excited to share this preprint of my postdoc work, only several years late to the party 🎉

We examined how loss of function in SETD1A, a high confidence schizophrenia risk gene, impacts neural synchrony across circuits supporting working memory in mice.

www.biorxiv.org/content/10.6...

Very cool! Just out of curiosity, what proportion of prelimbic gabaergic interneurons are positive for cortistatin? Is that similar to what’s seen in human brain?

New paper out on cortistatin neurons and their role in regulating fear and cortical hyperexcitability in the prelimbic cortex! This one has been a fun ride 🧵 www.biorxiv.org/content/10.6...

Survey: Should neuroscience focus on big team science? Learn which types of projects are better for big team science versus smaller-group support.

Should neuroscience focus on big team science or the traditional model? Explore what survey respondents had to say about it: www.thetransmitter.org/funding/shou...

#neuroskyence #StateOfNeuroscience

A probabilistic deep learning approach for choroid plexus segmentation in autism spectrum disorder - NPP—Digital Psychiatry and Neuroscience The choroid plexus plays an important role in brain health and immunity and may be altered in autism spectrum disorder (ASD). To analyze large imaging datasets, a method to automatically delineate thi...

🆕in DPN:

Bargagna et al used a probabilistic deep learning model to automate MRI segmentation of the choroid plexus, demonstrating accurate results in an autism cohort and quantifying model confidence across multiple datasets.

www.nature.com/articles/s44...

YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN) New deep learning tool allows automated analysis of sleep patterns using EEG data

Our latest Deep Dive covers a study that developed a deep learning model to classify sleep stages from single channel EEG recordings in rats🐀. It predicted key parameters of sleep architecture, reducing the need for labor-intensive manual annotation.

youtu.be/kEgCbyqC0jU?...

@dranap.bsky.social

I am not sure POs are clear on these issues either…

still talking about this study group - one for the books 📚 🫶🏻

I couldn't pick just one, but I had such a great time at #ACNP2026! Thank you so much for the past travel award support!! Always amazing to see the reviewers for @npp-journal.bsky.social and @dpn-journal.bsky.social each year (and to be a top reviewer again this year).

Thrilled to share that I was promoted to Full Member! 🎉 🙌Grateful for the incredible mentorship, support, and community that made this milestone possible. Thanks to everyone who believed in me, including Tony Grace + @jaredwyoung.bsky.social for their letters, and to @acnporg.bsky.social 🙏 #ACNP2026

I should have taken a selfie after #SachinSays poured a drink all over me last night in classic fashion. But, alas, I did not, so here is a #ACNP2026 Atlantis hippocampus. Thanks to everyone for a great meeting - so many friends to catch up with, exciting science convos & a little too much fun 😴

Thank you all for an unforgettable #ACNP2026 full of cutting-edge science, insightful discussions, and positive energy!

See you next year in San Diego for #ACNP2027!

So good to see you and catch up!! Hope we cross paths again soon 😆

📸 One last favor: Share your favorite photo from the meeting and tag us! We’d love to see #ACNP2026 through your eyes.

Until next year... stay inspired!

Picture of conference attendees at ACNP 2026 annual meeting

Picture of conference attendees at ACNP 2026 annual meeting

Picture of conference attendees at ACNP 2026 annual meeting

Picture of conference attendees at ACNP 2026 annual meeting

I had a fabulous time learning about new science and spending quality time with my favorite people at #ACNP2026. Until next time!

@acnporg.bsky.social @madrelabutd.bsky.social @brainbodylab.bsky.social

Last day of #ACNP2026!

Head over to Poseidon III-IV this morning from 9-11 to hear about how cross-species functional brain biomarkers are being used to improve translation and facilitate drug development in psychiatry 🧠

What a powerful conversation about what it’s like to navigate life and a research career with lived experience of mental illness. I’m deeply grateful for the speakers being willing to share their experiences and how we can all be more supportive of our colleagues #ACNP206 @acnporg.bsky.social

Love some swag #ACNP2026

Screenshot of trivia question at ACNP annual meeting

Day 2 of #ACNP2026 trivia starts now!