Andrew Mendiola

200 days in, checking in on HHMI funding opportunities:

Freeman Hrabowski Scholars Program - not accepting applications

Gilliam Fellows Program - not accepting applications

Hanna H. Gray Fellows Program - not accepting applications

Investigator Program - not accepting applications

Just to give the TL;DR on this one:

*The* main purpose of the EO is to move funding priorities and decisions away from experts and career professionals over to political appointees. With the ultimate power held by Vought / OMB.

Thank you!!!🙏🏽

Thanks!!!

Thanks, Misha!!!

Thanks!

Thanks, Benoit!!

Interested in keeping track
R01 first submission Oct 24 to NINDS (ESI/NI status)
SS April (Initially Feb)
Council May
1st JIT June (Council Rev completed status)
2nd JIT July (pending eRA status)
NoA August
*NINDS staff are amazing

Thrilled to share that I received the NoA for my first R01 “Mechanisms of pathogenic microglial populations in CNS inflammation”. Major milestone for the Lab. Extremely grateful for SS/SRO, PO and everyone else at NINDS for their continued support. Photo of my lab, wife and son, celebrating!

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...

EBV induces CNS homing of B cells attracting inflammatory T cells - Nature Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

www.nature.com/articles/s41...

Quote for a 63x objective. The objective is $12,784. The tariff is $1,661.92

Zeiss 63x objective

We need a new microscope objective. A $1.6k tariff for something that you can hold in your hand and that is only manufactured in Germany

www.sciencedirect.com/science/arti... Great review on "Alzheimer’s disease and vascular biology – A focus on the procoagulant state"

Surreal…

congrats!

lol

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance Alzheimer's disease (AD) is not only characterized by amyloid-beta (Aβ) and tau pathology, but also by early and progressive disruptions in metabolism. Neuronal excitability is tightly coupled with me...

🔥New preprint from the lab! Led by @rileyirmen.bsky.social

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

📍 biorxiv.org/content/10.1101/2025.07.25.666872v1

🧵 on how tau disrupts the metabolism–excitability balance in Alzheimer’s disease

Full Committee Markup of Defense and Labor, Health and Human Services, and Education Appropriations Acts | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

Happening Now!

Mark-up of Labor, Health, and Human Services

www.appropriations.senate.gov/hearings/ful...

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray.

"Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

🎉

exciting and congrats!

I was just thinking the same thing

I hope this true!

Trump Administration Scraps Effort to Pause Health-Research Funding The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...

What does this mean?

A researcher with hearing loss got a grant to study restoring hearing. The Trump administration cancelled it because of DEI | CNN Dr. Uri Manor feels like much of his early life was blessed by fate.

Dr. Uri Manor feels like much of his early life was blessed by fate.

The NIH was healthiest when pay lines were in the 20th percentile range.

We are headed into an environment where pay lines are in the 5% range.

In my entire career, I’ve only had 3 grants that scored better than 5%. And my lab is considered a successful one.

This is going to destroy science.

@manorlaboratory.bsky.social !

Academic chairs waiting for endowments #academia

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.