Anirudh Wodeyar

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯

#neuroskyence #compneurosky

doi.org/10.1038/s415...

VACANCY:
Assistant Professor in AI in Digital Agriculture and Sustainability.
lnkd.in/gFKhd32z

Professor Christopher Brewster and his team are looking for a highly qualified computer scientist with a broad passion for food and agriculture, environment, and biodiversity.

@cawbrewster.bsky.social

Brain implant lets man 'experience joy' for the first time in decades A device that has been likened to a pacemaker for the brain has given a man with severe depression great relief

A man who had severe depression for more than 30 years has "experienced joy" after undergoing bespoke brain stimulation.

Brain–computer interface control with artificial intelligence copilots - Nature Machine Intelligence AI copilots are integrated into brain–computer interfaces, enabling a paralysed participant to achieve improved control of computer cursors and robotic arms. This shared autonomy approach offers a pro...

Brain–computer interface control with artificial intelligence copilots

#MLSky #CompNeuro #NeuroAI

www.nature.com/articles/s42...

Are we heading for a world where no one ever needs to talk to another human being? Self-service tills, apps for shopping and takeaways, silent hair salons, driverless taxis – why are we going to extreme lengths to avoid engaging with each other?

A major way we avoid talking to another human being is by driving cars.

1. The philosophy of science sometimes gets an unearned reputation as a purely academic exercise that offers little by way of concrete tools for advancing research.

This is wrong.

And today, as we grapple with how AI is changing the nature of scientific activity, it's desperately wrong.

You know, thinking of Reviewer 2 as the bear is actually kind of helpful to me psychologically - I see the bear as just trying to make some friends... He _is_ walking away looking awfully lonely at the end.

At what point do you run home and get under the blanket?

‘Absolutely insane.’ Dragonfly’s extreme loop-the-loops are unparalleled in nature Insects use “crazy turning” to dry off after a cooling dip in water

My favorite kind of science: www.science.org/content/arti...

I feel I've observed this (dragonflies dipping into water then doing loop-de-loops) in the wild but never fully reflected on the why. The science involved and the experiments required to expose it are delicious to understand :)

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge? Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 P...

on the same notion but here we see an expansion of that idea.

In the linked post, researchers saw that using tDCS set up perhaps a favorable brain state for a drug effect.

onlinelibrary.wiley.com/doi/10.1002/...

Work from @andreashorn.org and colleagues.

I hope (and suspect) that we will see more of this style of reasoning into the future in several areas. Essentially, you can more effectively enable brain state changes _from_ specific brain states. The idea has existed in other forms elsewhere - tracking phase of oscillations is a variation ...

Here's a bit of spice. Brain research clearly needs to tackle more complexity (than, say, Step 1: simple linear causal chains). But that leaves an ~infinite set of alternatives. Here, @pessoabrain.bsky.social advocates not for just a step 2, but a 3. /1

arxiv.org/abs/2411.03621

Closed-loop neuromodulation in an individual with treatment-resistant depression - Nature Medicine This case report describes a biomarker-driven closed-loop therapy for depression using implanted electrodes to continually sense brain activity and automatically trigger direct brain electrical stimul...

Was just thinking about this paper the other day and how much I enjoyed the way they set up the study. They figured out what brain dynamics were most linked to depressive symptoms, what it took to change that state and used that to implement a closed-loop system. Would love to be pointed to more...

That said, developing tools to understanding what is a state (perhaps this is equivalent to an attractor), what are the possible states, tracking states in real-time and assessing what it takes to move from one state to another, is a direction I'm truly excited to engage with.

Similar network activity from disparate circuit parameters - Nature Neuroscience Nature Neuroscience - Similar network activity from disparate circuit parameters

My suspicion is that degeneracy (the states possible under one set of parameters vs another can be the same) makes this kind of inference (i.e. assessing whether the system changed or it just received sufficient input to reach a new state) difficult. A classic: www.nature.com/articles/nn1...

Awesome!

French scientist denied US entry after phone messages critical of Trump found France’s research minister said the scientist was traveling to Houston for a conference when his phone was searched France’s research minister said a French scientist was denied entry to the US this month after immigration officers at an airport searched…

French scientist denied US entry after phone messages critical of Trump found

I’d 💯 recommend being a TA for @neuromatch.bsky.social
The best way to learn is teach.
And the best way to teach is with phenomenal materials that are well structured and have solutions.

See the figure attached below.

The green line and shading represents thalamic spindle coupling in the absence of a coupled thalamic spikes while the orange/red line and shading represents the thalamic spindle coupling in the presence of epileptic spikes.

This observation of reduced slow oscillation-spindle coupling may be explained by the mechanism that we proposed in a paper last year that when slow oscillations are coupled with epileptic spikes that reach the thalamus, spindle occurrence is reduced (see Figure 2D): academic.oup.com/brain/articl...

Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...

Quite enjoyed passing through this new review: www.nature.com/articles/s41... on the interaction between epilepsy and sleep.

Earlier work from @laurentsheybani.bsky.social et al. on local wake slow oscillations were cool observations that I could finally go through: www.nature.com/articles/s41...

Honestly any odds ratio should come with an expected frequency icon array. Just so much more interpretable.

All odds ratios on this scale should ideally come with an icon array of expected frequencies under exposure vs without.

Oof this style of reporting is exhausting. Read thread!

Striatal stimulation enhances cognitive control and evidence processing in rodents and humans Developing an animal model of human brain stimulation therapy reveals that striatal DBS enhances the brain’s ability to process conflicting evidence.

Out today: cross-species improvement of cognitive flexibility
www.science.org/doi/10.1126/...

The TLDR: remember when we improved human cognition with deep brain stimulation? (pubmed.ncbi.nlm.nih.gov/34725508/)
Well, now we did it in rats, and it works the same!
Specifically... 1/

Discovering EEG biomarkers of Lennox–Gastaut syndrome through unsupervised time–frequency analysis Objective The discovery and validation of electroencephalography (EEG) biomarkers often rely on visual identification of waveforms. However, bias toward visually striking events restricts the search...

The observation from Hu et. al. that sleep spindles seem negatively linked to discharges in Lennox-Gastaut (onlinelibrary.wiley.com/doi/10.1111/...) fits with our past work on epilepsy patients where epileptic spikes were disrupting sleep spindles (dx.doi.org/10.1093/brai...).

Auditory Enhancement of Sleep Slow Waves in People with Parkinson’s Disease: A Proof-of-Concept Study Deep sleep supports several restorative functions and has emerged as a potential therapeutic target in neurodegenerative disorders, such as Parkinson’s disease (PD). Phase-targeted auditory stimulatio...

Starting to wonder if the gains of auditory stimulation at night are reserved for folks who already have impairment of some kind. Everything I've seen so far would fit that expectation. www.medrxiv.org/content/10.1...

Thanks!

I'm curious what other examples demonstrate the idea that "control is as important as constraints" - I've heard of Ashby in these contexts but wondering what's a good ref to go to for a field agnostic take on this.

Random auditory stimulation disturbs traveling slow waves and declarative memory Sleep plays a crucial role in memory consolidation, and various methods have attempted to enhance this process by using auditory stimulation to modulate slow waves or trigger memory reactivation. Howe...

The story of auditory stimulation to induce seeming slow oscillations in sleep gets ever more complicated: www.biorxiv.org/content/10.1...