Laurent Sheybani

High frequency opportunities for Alzheimer’s disease This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

🚨 Great scientific commentary by Christos Lisgaras --> academic.oup.com/braincomms/a...

High frequency oscillations in neurodegenerative disorders. Have a look !

The project is planned for 3 years in collaboration with Prof. @anitaluthi.bsky.social (UNIL) and Prof. Serge Vulliémoz (UNIGE). Funded by the @snsf.ch

The project builds upon my recent publications in Nature Communications (doi: doi.org/10.1038/s414...), Neurology (doi: doi.org/10.1212/WNL....) and Nature Reviews Neurology (doi: doi.org/10.1038/s415...).

💡🧠⚙️🔬💡
If you are curious to know more about epilepsy and sleep, check the call !

We are hiring !

👩🏼‍🎓👨‍🎓🧑🏼‍🎓👨🏿‍🎓👩🏿‍🎓👩‍🎓

I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep.

If you are interested, check the job announcement:
jobs.unige.ch/www/wd_porta...

This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry

A big thank to the @snsf.ch, Geneva University (UNIGE), University Hospitals of Geneva (HUG) and @unil.bsky.social

For this project, a PhD and postdoc position will open ! If you are interested in epilepsy and sleep, STAY TUNED !!

Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.

Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones Objective Epilepsy is a debilitating disorder affecting more than 50 million people worldwide, and one third of patients continue to have seizures despite maximal medical management. If patients' se...

Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones -->
doi.org/10.1111/epi....

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...

Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy?
doi.org/10.1038/s415...

Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis - Scientific Reports Scientific Reports - Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis

Just published my first paper!
Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible.

huge thanks to my co-authors — couldn’t have done it without you.

If you want to check it out:
📄 paper: www.nature.com/articles/s41...

Geneva Explore Pint of Science Switzerland events in Geneva

Pint of Science in Geneva! This week. Program here: pintofscience.ch/events/geneva

@pintofscience.ch

Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep Mammalian sleep alternates between sensory-responsive and protected offline periods via coordinated neural and cardiac rhythms.

Made me think of your paper:
www.science.org/doi/10.1126/...

Autonomic physiological coupling of the global fMRI signal - Nature Neuroscience The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

doi.org/10.1038/s415...
@anitaluthi.bsky.social

Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans - Nature Communications Neural mechanisms underlying thalamic contributions to evoked potentials by brain stimulation, which has been widely used for therapeutic interventions, are not fully understood. In this translational...

Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41....
Fascinating to see this complex network elicited by 'artificial' stimulation.
Well done @simonerusso.bsky.social and team!

Encouraging phase 2 trial in fronto-temporal dementia ->

Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice.
@ilae-epilepsy.bsky.social

Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show that differences typically observed between vigilance states in neural dynamics and spectral signatures can be mark...

Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...

At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications:
doi.org/10.1093/brai...

Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants D’Gama et al. studied a prospective patient cohort being evaluated with stereo-EEG electrodes for seizure localization. They identified somatic mosaic vari

Mosaicism in the brain:
doi.org/10.1093/brai...
Complexity should be seen as an opportunity...

Widespread decoupling of spindles and slow waves in temporal lobe epilepsy Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs)...

Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy -->

doi.org/10.1111/epi....

Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep.
Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding:
@snsf-ch.bsky.social
Guarantors of @brain1878.bsky.social

Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...

Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how?
We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology:
doi.org/10.1038/s415...

@natrevneurol.bsky.social

Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies Epilepsy is a cortico-subcortical network disorder. By analyzing thalamo-cortical relationships in 121 patients through stereotactic-EEG, Biagioni et al. i

Thalamic activity during wake and sleep in 121 people with epilepsy -->
academic.oup.com/braincomms/a...

@dgiampiccolo.bsky.social

Can you learn while sleeping? Does sleep help you solve problems? What is the effect of sleep on brain metabolism?
--> my last editorial @braincomms.bsky.social
doi.org/10.1093/brai...

Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!

How can we improve the chance to record seizures during intracranial monitoring of people with drug resistant epilepsy?
Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!)
--> doi.org/10.1111/epi....

Pupil size reveals arousal level fluctuations in human sleep - Nature Communications Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...

Pupil size as an index of sleep states -->
www.nature.com/articles/s41...

See also www.nature.com/articles/s43...

Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.

Very interesting paper by Alfonsa et al. @currentbiology.bsky.social. Switch in EGABA associated with long period of wakefulness shapes LTP.
@vyazovskiy.bsky.social
doi.org/10.1016/j.cu...

Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson’s disease Pasquini et al. explore microstructural abnormalities in LC and SN through neuromelanin and diffusion MRI in Parkinson’s disease and iRBD. They also show a

Great work on substantia nigra and locus ceruleus microstructural abnormalities in REM sleep behavior disorder and Parkinson's disease. Now in @braincomms.bsky.social
doi.org/10.1093/brai...