Andreas Lossius

@biorxivpreprint.bsky.social @lossiusandreas.bsky.social
Putative target antigens of the stereotyped intrathecal B cell response in multiple sclerosis
www.biorxiv.org/content/10.6...

Postdoctoral Research Fellowship in Immunology A 3-year postdoctoral fellowship is available at the Department of Immunology, Oslo University Hospital. The position will be located in the lab of Dr. Rasmus Iversen and will be available from March ...

A 3-year postdoc position in experimental immunology is available in our lab at Oslo University Hospital. If you know someone who is interested in B cells and autoimmunity, please spread the word! You can find more information and apply for the position here: 2411.webcruiter.no/Main2/Recrui...

PhD fellowship in cancer research - Oslo, Østlandet (NO) job with Oslo University Hospital - Department of Pathology | 12851095 A fully funded three-year full-time PhD fellowship in cancer research is available at the Department of Pathology, Oslo University Hospital, Norway.

A PhD fellowship in our lab is available. If you or someone you know is interested in exploring how we can activate antiviral responses to kill cancer cells, please spread the word!

Don't hesitate to get in touch if you have any questions. Link:
www.nature.com/naturecareer...

Happy to see this work on IG light chains from @e-engelbrecht1.bsky.social in press www.nature.com/articles/s41...
How else will germline variation impact the expressed repertoire? Can't wait to see!
Thanks to awesome collabs:
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase Abstract. Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune respons

🧬 VDJbase and OGRDB: 3000+ IG/TR samples across human and rhesus macaque with curated AIRR-seq and long-read genomic data.
LET'S CHANGE THE WAY WE UTILIZE IG/TR GENOMIC AND REPERTOIRE DATA! @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social
academic.oup.com/nar/advance-...

The human IG heavy chain constant gene locus is enriched for large structural variants and coding polymorphisms that vary among human populations Genetic variation within immunoglobulin heavy chain constant (IGHC) genes modulates interactions between antibodies and other immune receptors and effector cells, directing cell killing and the cleara...

Happy to announce the publication of our work exploring under-appreciated genetic diversity in the human IGHC region. Awesome work by @uddalok.bsky.social. So grateful for our amazing co-authors.
@williamlees.bsky.social @guryaari.bsky.social @ayeletperes.bsky.social

www.cell.com/cell-genomic...

📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...

PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025

We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...

GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...

Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬
www.biorxiv.org/content/10.1...

GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...

New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...

#scRNAseq #immunology

Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!

www.biorxiv.org/content/10.1...

Human genetic variation shapes the antibody repertoire across B cell development The peripheral antibody repertoire is shaped by inherited genetic variation and selection during B cell development. However, how the repertoire changes across developmental stages—and the relative im...

New preprint from our group in collaboration with the awesome Prof. Ranjan Sen (NIH). We show that IGH polymorphisms establish inter-individual differences in the pro-B antibody repertoire that persist into the naive B cell pool. Oscar L. Rodriguez is killing it! www.biorxiv.org/content/10.1...

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...

Lovisenberg Diakonale Sykehus Postdoctoral research fellowship in Bioinformatics and Immunology (3-year, full-time)

We have available a 3-year postdoc position in Bioinformatics in our lab at the University of Oslo focusing on the adaptive immune response in rheumatoid arthritis. Please see details here
lds.easycruit.com/vacancy/3490...

The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...

Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social

www.biorxiv.org/content/10.1...

Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells.
www.biorxiv.org/content/10.1...