Andreas Lossius

PhD Fellowship in Computational Systems Immunology (286608) | University of Oslo Job title: PhD Fellowship in Computational Systems Immunology (286608), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025

We’re recruiting a PhD Fellow in Computational Systems Immunology. Work on large-scale immune receptor datasets and develop computational models in close collaboration with experimental labs. Apply here: www.jobbnorge.no/en/available...

GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...

Interested in BCR analysis, including paired heavy-light chain and constant region?👀 Check out our new tool for reconstructing BCRs from scRNAseq! Compatible with 10x and Smart-seq🧬
www.biorxiv.org/content/10.1...

GATHeR: Graph-based Accurate Tool for Immunoglobulin HEavy- and Light-chain Reconstruction Recovering full-length, paired B-cell receptor (BCR) sequences from scRNA-seq reads remains difficult, especially in naive and memory B cells where immunoglobulin transcripts are sparse. Current metho...

New BCR reconstruction tool for scRNA-seq: assembles full heavy & light chains and annotates constant regions. Check it out:
www.biorxiv.org/content/10.1...

#scRNAseq #immunology

Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!

www.biorxiv.org/content/10.1...

Human genetic variation shapes the antibody repertoire across B cell development The peripheral antibody repertoire is shaped by inherited genetic variation and selection during B cell development. However, how the repertoire changes across developmental stages—and the relative im...

New preprint from our group in collaboration with the awesome Prof. Ranjan Sen (NIH). We show that IGH polymorphisms establish inter-individual differences in the pro-B antibody repertoire that persist into the naive B cell pool. Oscar L. Rodriguez is killing it! www.biorxiv.org/content/10.1...

Germline polymorphism in the immunoglobulin kappa and lambda loci explain variation in the expressed light chain antibody repertoire Variation in antibody (Ab) responses contributes to disease outcomes and therapeutic responsiveness, the determinants of which remain incompletely understood. This study demonstrates that polymorphism...

Turns out...just like in the antibody heavy chain repertoire, germline variants in the immunoglobulin lambda and kappa loci influence the composition of light chain B cell receptors!
Way to go Eric @e-engelbrecht1.bsky.social !!!!
www.biorxiv.org/content/10.1...

Lovisenberg Diakonale Sykehus Postdoctoral research fellowship in Bioinformatics and Immunology (3-year, full-time)

We have available a 3-year postdoc position in Bioinformatics in our lab at the University of Oslo focusing on the adaptive immune response in rheumatoid arthritis. Please see details here
lds.easycruit.com/vacancy/3490...

The human immunoglobulin heavy chain constant gene locus is enriched for large complex structural variants and coding polymorphisms that vary in frequency among human populations The immunoglobulin heavy chain constant (IGHC) domain of antibodies (Ab) is responsible for a variety of effector functions critical to Ab mediated immunity. In human, this domain is encoded by genes ...

Did you know that human immunoglobulin constant genes are crazy diverse? It's got me thinking...Proud of Uddalok Jana! And grateful for collabs @guryaari.bsky.social @williamlees.bsky.social @ayeletperes.bsky.social @e-engelbrecht1.bsky.social @yscientist.bsky.social
www.biorxiv.org/content/10.1...

Ultra-long sequencing for contiguous haplotype resolution of the human immunoglobulin heavy chain locus Genetic diversity within the human immunoglobulin heavy chain (IGH) locus influences the expressed antibody repertoire and susceptibility to infectious and autoimmune diseases. However, repetitive seq...

Check out long-read sequencing results in human IGH! HUGE duplications in constant gene regions...and 7 copies of IGHV3-23 on one haplotype! @lossiusandreas.bsky.social @williamlees.bsky.social

www.biorxiv.org/content/10.1...

Our collaborative paper on #Nanopore sequencing is now available on #BioRxiv. Among several new variants, we characterize a large duplication in the IGHC region, suggesting non-canonical class switching between the duplicated isotypes in #Bcells.
www.biorxiv.org/content/10.1...