Prof John Gordon

Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer Osorio et al. report a first-in-human study of intratumoral 2141-V11, an Fc-engineered CD40 agonistic antibody, showing it is safe and induces systemic and durable antitumor immunity in patients with ...

#cancersky #immunosky #antibodysky

Major #CD40 #TherapeuticAntibody Success now breaking
@cp-cancercell.bsky.social

First-in-Human study of Fc-optimised CD40 agonistic Antibody elicits #TertiaryLymphoidStructures & systemic anti-Tumor #Immunity in Metastatic #Cancer

Fantastic work 👏

Dr Neil Bodie (June 13, 1955 - July 19, 2025)

It is with a heavy heart that I report the sad news that my "LinkedIn Friend" & Colleague Dr Neil Martin Bodie, passed away on July 19th.

For more about Neil please see: www.linkedin.com/feed/update/...

R.I.P. Dear Friend

Thoughts are with his family

Major study, great work 👍

St David’s 🤔 🏴󠁧󠁢󠁷󠁬󠁳󠁿

Inflammation Perfect Storm: Cancer, Climate and Polarisation Interplay between major global challenges and human health. Climate change and sociopolitical polarisation act as overarching amplifiers, driving specific environmental and psychosocial/policy-relate...

#immunosky #cancersky #climatechangesky

#PsychoNeuroImmunology

#ClimateChange / #SocialDivision: A Perfect Storm for Chronic #Inflammation to Seedbed #Cancer?

Intriguing, OPEN ACCESS Opinion Piece now breaking at @wiley.com #Immunology

A Perfect Selection 😉

Fantastic advance 👏

Clucking Awesome 🐓

A fantastic #MS resource from @britsocimm.bsky.social 👍

Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell ...

#Immunosky #Cancersky

Antidepressants: A “Dead SERT” for #Immunotherapy!

Open Access @cellpress.bsky.social

@gilliangrafton.bsky.social 😎

Tissue mechanics in tumor heterogeneity and aggression Tumorigenesis ensues within a heterogeneous tissue microenvironment that promotes malignant transformation, metastasis and treatment resistance. A major feature of the tumor microenvironment is the he...

#CancerSky #MedSky

"When #Cancer #Therapy faces STIFF competition"

OPEN ACCESS Review @cp-trendscancer.bsky.social

GLUT5 armouring enhances adoptive T cell therapy anti-tumour activity under glucose-limiting conditions AbstractBackground. Cancer immunotherapy with engineered T cells has become a standard treatment for certain haematological cancers. However, clinical tria

#ImmunoSky #MedSky #CancerSky

"Strengthening the #GLUT5" for #ACT vs Solid #Tumours"

Breaking OPEN ACCESS Study @britsocimm.bsky.social journal @imtadvances.bsky.social 👏

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

#ImmunoSky #InflammationSky #DietSky

#ILC3s #Immunity #Inflammation #Mucosa #Metabolism #Nutrition #Diet #IL22

"Trust Your #Gut" & Stay Off those Big Macs 🍔

@wehi-research.bsky.social researchers Cyril Seillet & Friends "Chew the #Fat" in Breaking OPEN ACCESS Study @cp-immunity.bsky.social

#ImmunoSky #MedSky #CancerSky #PharmaSky #DrugSky

**BREAKING: Massive layoffs hit the rodent workforce!**

In a historic shift, the FDA is exploring a future without animal studies for drug approvals.

BRILLIANT Joseph Arboleda Velasquez @harvard.edu 🤩👍👏

www.linkedin.com/posts/joseph...

#CancerSky #ImmunoSky #MedSky

#Cancer #Aging #Metabolism

#TIME to Watch you Eat'

#Age- & #Diet- instructed Metabolic Rewiring of the #TumorImmuneMicroEnvironment

#TIME-ly review from @unil.bsky.social authors now breaking at @jem.org

rupress.org/jem/article/...

…though #Bcells #Antibodies ARE important 😉

The antipsychotic drug thiothixene stimulates macrophages to clear pathogenic cells by inducing arginase 1 and continual efferocytosis Macrophages perform repeated rounds of phagocytosis in response to an FDA-approved dopamine blocker.

#ImmunoSky #MedSky

#drugrepurposing

#Inflammation: "Time to halt the #Dopamine rush"

An anti- #Psychotic Drug stimulates #Macrophages to clear #Pathogenic Cells by inducing #Arginase-1 & continual #Efferocytosis

Now @science.org signaling

😊

From Serendipity to Success - Researcher blogs % | John Gordon #Serendipity | Delighted to share this lovely post from the hugely talented Austeja Baleviciute of the Karolinska Institutet 😊 Hopefully will offer some useful tips to early career researchers as they...

#ImmunoSky
#MedSky
#EarlyCareerResearchers
#Careers
@ki.se

#ImmunoSky

#Immunotherapy
#ImmuneRelatedAdverseEvents
#Biomarkers

#ICOS+ CD4 #Tcells define #Susceptibility to anti-PD1-induced #Lung #Pathology in the #Aged

#Bcells #Antibodies #TertiaryLymphoidStructures

Breaking Open Access Study @jci-insight.bsky.social

insight.jci.org/articles/vie...

Maximizing activity & selectivity of #TherapeuticAntibodies mediated effector functions using Antibody mixtures

Breaking Open Access Study* @tandfresearch.bsky.social #mAbs

*https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2480666?src=exp-la#abstract

#flu #vaccine #protective #antibody #jem #bcells #vaccinessavelives | John Gordon Towards a pan-#Flu #Vaccine | Identification of a Seasonal Influenza Vaccine-induced Broadly #Protective Neuraminidase #Antibody | Breaking Open Access Study at Rockefeller University Press #JEM | #Bc...

#Bcells & #VaccinesSaveLives

Towards a pan- #Flu #Vaccine

Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody

Breaking Open Access Study* @jem.org

*https://rupress.org/jem/article/222/6/e20241930/277361/Identification-of-a-seasonal-influenza-vaccine

#biohubis10 | University of Birmingham Enterprise BioHub-based Celentyx Ltd is a highly specialised contract research organisation (CRO) that delivers services across a broad range of therapeutic areas…

#Celentyx

Frontiers | Decoding plasma cell maturation dynamics with BCMA

#Bcells #Antibodies #PlasmaCells

It’s #APRIL 😎

Don’t be a Fool - Read this 👍

Surely you should have Tweeted this Gillian 🧐 Oops! Forgot - that’s now X-rated 🤓

#bcells #gag #syndecans #plasmacell #cd138 #pc #antibodies #bespoke… | John Gordon #Bcells are "#GAG"-ing for it | #Syndecans Impact Development & Activation | Multiple Highlights in Breaking Study at EMBO Reports: incl. that Quintessential…

FANTASTIC #BCELLS WORK 👏

Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress - BioDrugs Autoimmune diseases are highly prevalent and affect people at all ages, women more often than men. The most prominent immunological manifestation is the production of antibodies directed against self-...

Targeting the #FcRn in #AutoimmuneDiseases: Pipeline & Progress

Torleif Tollefsrud Gjølberg & Colleagues Dig Deep into the Biology of the Neonatal Fc Receptor & its Antagonism in Superlative Breaking Open Access Review

#MyeloidCell path to #Malignancy: insights into #Liver #Cancer

SUPERLATIVE OPEN ACCESS REVIEW from Christel Ramirez & @leilaakkari.bsky.social at @cp-trendscancer.bsky.social 👏

www.cell.com/action/showP...

🐑👍

Time to Zap moDc to reverse #Radiotherapy resistance ☢️

Breaking Open Access Study @jem.org 👍