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The baby whose life was saved by the first personalized CRISPR therapy KJ Muldoon is part of Nature’s 10, a list of people who shaped science in 2025.

Biotech is just inherently slow compared to other fields. Here’s the best CRISPR story from last year.

www.nature.com/articles/d41...

halftime show fromt eh supebowl showing a set on the field featuring a nyc bodega

This kind of smart, walkable, mixed-use urbanism is illegal to build in most American cities.

It’s partially downstream from education polarization

Looks like a UFO invasion… but very pretty. Heavy air traffic at #ORD tonight. #timelapse #lakemichigan #chicago ✈️

It’s actually insane to read the business section of his wikipedia page.

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia | NEJM In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is d...

Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....

Congestion pricing after one year: How life has changed. (Gift Article) How life has changed in the New York area, according to data on traffic, transit and the responses of 600 readers.

The latest numbers are in: Congestion pricing cut 27M car trips in 2025.
Commutes got faster
Streets got safer
And business went up
See more exclusive analysis - and feedback from 600+readers - in our latest collab with @upshot.nytimes.com
Free link:

www.nytimes.com/interactive/...

The names of our most important streets still carry their historical roots at heart. Avenues, parkways, and boulevards bear a proud civic legacy—spaces once meant for recreation, gathering, and promenade. To uncover these layered histories is to glimpse another way of inhabiting the city.

These medical breakthroughs and advances gave patients new hope in 2025 Advances delivered what may feel like medical miracles, including the first bladder transplant, a lifesaving personalized gene therapy and more.

American science took a beating this year, with cuts to funding and jobs. And yet, scientists persisted and made progress. These advances in 2025 spotlight how crucial it is to support biomedical research — and how much of an impact it can have on people’s lives.
www.sciencenews.org/article/medi...

When you're brainstorming about bioproduct ideas one thing you look for is signs of an unmet market need

photo of the inside of a cta train with a blur of lights outside

yellow line
skokie, illinois

The first patients have been helped by cancer-fighting cells made directly in their bodies Novel approach could be faster, and cheaper, than making the cells in the lab—but safety concerns linger

www.science.org/content/arti...

the people of this great republic yearn for locomotive transport

Holiday Lights of Chicago.

An almost all white, snowy scene in Chicago's Grant Park. A few sledders come down a hill in the foreground and mid ground. A statue of General John Logan is covered in snow in the middle of the frame, while blotted out skyscrapers are barely visible in the background.

Sledding amongst skyscrapers in #Chicago on an incredibly snowy Novemeber day

Snowy day at the corner of Clark and Addison. Good morning from Chicago.

They did it again! NYC subway Thanksgiving 2025, via @scootercaster.com!

a few of my favorite snowy owl shots from yesterday in Chicago #birds 🪶

CTA Holiday Train!!!

Fun fact: dialysis consumes about 1% of the total spending by the federal government each year.

40 years of life: the miracle of ‘Baby Moses’ and the heart that changed medicine | News First and longest-living infant-to-infant heart transplant recipient celebrates 40th birthday at reunion event.

Via a friend: the recipient of the first successful neonatal heart transplant celebrated his 40th birthday a few days ago, still with the same donor heart transplanted into him when he was just days old: news.llu.edu/patient-care...

It shouldn’t be forgotten that a big piece of Mamdani’s campaign was simply “cities are cool and lots of people enjoy living in them” which in and of itself dismantles alot of rightwing talking points

Below, GSK CEO Emma Walmsley meets Baby KJ, the child who was treated with CRISPR gene editing by researchers at Children's Hospital of Philadelphia.

It was one of the biggest moment from #STATSummit. You can read about that moment and more here: www.statnews.com/2025/10/24/p...

To be fair to Illinois, the current map is pretty brutal for Republicans.

Candle in the Windy City. This morning's sunrise highlights the steam coming off the top of the St. Regis building in Chicago.

Magnificent Monday Morning. Today's sunrise in Chicago.

DB-OTO Gene Therapy for Inherited Deafness | NEJM Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...

New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

New England’s last coal plant has stopped operating, according to its owners Granite Shore Power, the company that owns the coal plant in Bow, New Hampshire, said they ceased commercial operations Sept. 12, about a year and a half after they announced they would retire their f...

With Merrimack Station shutting down in New Hampshire, there will no longer be coal burned in New England to power the grid.