Adam Pickrum

We're hiring! Check out our ad and please re-post or forward to interested #Microbiology parties: apply.interfolio.com/174783

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...

Thrilled to share my work from the @jkagan1.bsky.social lab!

TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!

www.biorxiv.org/content/10.1...

#microsky #immunosky

Dual transposon sequencing profiles the genetic interaction landscape in bacteria Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform for assaying the fitness of a comprehensive double ...

Dual transposon sequencing profiles the genetic interaction landscape in bacteria | Science https://www.science.org/doi/full/10.1126/science.adt7685?af=R

Microbiology and Immunology – Faculty Position (Ladder Rank) – Assistant Professor University of California, San Francisco is hiring. Apply now!

Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807

Last month I attended the #GRS and #GRC on Staphylococcal Diseases. The conference was an excellent opportunity to meet new colleagues, learn with and about the vibrant #Staphylococcal community, and get ideas on #Zinc #ZNG1 research, coming soon

Faculty Professor Associate - Full-Time | Vaughn Cooper We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Vibrio2026: The International Meeting on the Biology of Vibrios Fourwaves - Vibrio2026: The International Meeting on the Biology of Vibrios

Delighted to announce that The International Meeting on the Biology of Vibrios will be back next year!

Vibrio2026 will be held in Berlin in September 13-16. See you there Vibriologists!

event.fourwaves.com/vibrio2026/p...

Wrapped up another great #cshlhost25 meeting! Such a special place to share the awesome science going on around the world.

How to protect yourself from Vibrio vulnificus, the bacteria found in some coastal waters States are warning beachgoers about a summertime surge in infections from a frightening, flesh-eating bacteria found in coastal waters.

Interview with yours truly on what to do to protect yourself against the flesh-eating pathogen Vibrio vulnificus for the Associated Press

apnews.com/article/vibr...

Come be my colleague!

I've been very happy at UTSW Micro. Why?

Its a supportive environment full of excellent people. There's strong ambition, reflexive empathy, and excellent resources.

Nice! Congrats to you and the team. Looking forward to reading this one.

After some time in sunny Barcelona, I’m excited to kick off the #staphGRC this week! Ready for some awesome science.

Staphylococcus aureus exploits lipoic acid salvage to combat host oxidative stress Acosta et al. find that ADP-ribosylation of the lipoic acid carrier protein GcvH-L promotes Staphylococcus aureus resistance to oxidative burst and facilitates infection. ADP-ribosylation leads to a s...

Happy to share Iván’s first-author pub from the lab! www.cell.com/cell-reports...

Staphylococcus aureus: a model for bacterial cell biology and pathogenesis | Journal of Bacteriology When talking about Staphylococcus aureus, one usually has in mind the diseases that can be caused by this bacterium, ranging from mild skin and soft tissue infections, such as abscesses and furuncles,...

"Among all bacterial species, S. aureus ranks second only to E. coli in the number of scientific publications."
It was a pleasure to contribute to this review, with @pinholab.bsky.social and Friedrich Götz
journals.asm.org/doi/10.1128/...

Excited to share this collaborative study with @ritatamayo.bsky.social showing that E. faecalis influences C. diff morphology through the phase variable CmrRST system! This work was co-led by the amazing team of @ashleyweiss.bsky.social and Jilarie Santos-Santiago!

Infection and Immunity is now welcoming nominations for highly promising scientists at the assistant professor level (or equivalent) to submit research to the next New Voices in Microbiology Collection!

Please nominate by the August 18 deadline using the below link:
app.asm.org/account/logi...

An illustration of a woman standing at a dead end looking at different roads and buildings. Text reads: My academic job offer was rescinded. I’ll keep going—but U.S. researchers are running out of road.

"I can’t predict the next hiring cycle or the next election. But I can keep doing the science I love while I still have a bench." #ScienceWorkingLife scim.ag/4lXUwDa

Methylglyoxal is an antibacterial effector produced by macrophages during infection Infected macrophages that transition to aerobic glycolysis produce the reactive aldehyde methylglyoxal. In this study, Anaya-Sanchez et al. use both host and bacterial genetics to show that methylglyo...

Methylglyoxal: antibacterial effector

Methylglyoxal produced by infected macrophages upon transition to aerobic glycolysis acts as an innate immune antimicrobial effector that bacteria must detoxify for virulence and to prevent mutations
www.cell.com/cell-host-mi...

Excited to post our first S. aureus preprint on biorxiv! Big congrats to co-first authors, postdocs @anjali20anil.bsky.social and Rezia Braza, and really enjoyed the collaboration with @torreslab.bsky.social !

Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...

Excited to share with you my postdoctoral work published today in Nature Microbiology!

www.nature.com/articles/s41...

We have known for a while that stress can impact the outcome of infectious diseases; however, we reveal in our paper that it is not always detrimental.

Microbial Pathogenesis & Host Response Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...

Infant immune systems respond differently to severe COVID-19 Infants show unique immune responses to COVID-19, differing from adults and children. New study may guide better treatments for severe infant infections.

Infants hospitalized with severe #COVID19 have different immune responses than adults or older children

@dnehar.bsky.social @jacksonlab.bsky.social

Judge rules against NIH grant cuts — and calls them discriminatory The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.

A US judge has ordered hundreds of terminated research projects at the US National Institutes of Health to be reinstated, calling the processes that led to their cancellation “bereft of reasoning”.

https://go.nature.com/4kOmXDy

Registration for MMPC 2025 opens today! We can’t wait to see you in St. Charles, IL, for the first MMPC hosted by Loyola University Chicago!
www.mmpconference2025.com/registration

NIH indirect cost cuts will affect the economy and employment - Nature Human Behaviour Nature Human Behaviour - NIH indirect cost cuts will affect the economy and employment

www.nature.com/articles/s41...
Every $1 spent on NIH funding returns nearly $3 to the economy - an almost 200% return on investment💰.
Also 99% of drugs developed 2010-2019 were funded by NIH ‼️🤯
Cutting NIH funding not only hurts the economy but will hurt families and patients 😔💔

Cutting the NIH—The $8 Trillion Health Care Catastrophe This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

Viewpoint in JAMA details the consequences of the proposed cuts to NIH:

❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually

All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...

Congrats to you and the team, Salvador!

Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence | PNAS The underlying factors that lead to specific strains within a species to emerge as human pathogens remain mostly enigmatic. The diarrheal disease c...

Pathogen emergence is a complex and rare phenomenon

Out of >40,000 named bacterial species only a fraction can cause disease in humans

What leads to this quantum leap? In our recent paper @pnas.org we decided to investigate this puzzling conundrum.

www.pnas.org/doi/10.1073/...