Alex Y. Kreins

1/ We are celebrating the Novo Nordisk Prize Symposium: Inborn Errors of Immunity – a huge success yesterday at the @institutimagine.bsky.social in Paris featuring talks by 19 leading European researchers on human IEI

Delighted to be speaking at the Novo Nordisk Symposium: Inborn Errors of Immunity, celebrating Jean-Laurent Casanova (my PhD advisor) and his landmark contributions. Join us Sept 24 at Institut Imagine, Paris. Free to attend!
Details & registration 👇
#NNFPrize #Immunology

Exciting milestone for #HumanImmunity with the very first full issue of @jhumimmunity.org out now, including the #IUIS update on inborn errors of immunity + resources for clinicians. rupress.org/jhi/issue/1/1 #OpenAccess #IEI 👏👏👏

Delighted to share our manuscript highlighting the lessons learned from the clinical use of ex vivo T-lymphopoiesis assays to assist therapeutic decision-making btw #HCT and #thymus transplantation in patients without a molecular diagnosis after TREC-based newborn screening 👉 tinyurl.com/yzd8xe7p

1/ I was honored to accept the 2025 Novo Nordisk Prize from @novo-nordisk.bsky.social at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of The BioInnovation Institute, lunch at @novo-nordisk.bsky.social, and an evening award celebration and dinner.

1/ Today we spotlight @sanchoshimizu.bsky.social, a postdoc in our Paris branch from 2006-12 and now Reader/Associate Professor at @imperialcollegeldn.bsky.social in the department of infectious diseases and head of both of a lab there and a satellite lab at the @crick.ac.uk

Rockefeller University Press launches new journal in partnership with scientists - News Open access, peer reviewed, and co-owned, the Journal of Human Immunity represents a new business model in scientific publishing.

Open access, peer reviewed, and co-owned, @jhumimmunity.org from @rupress.org represents a new business model in scientific publishing. Rockefeller's Jean-Laurent Casanova is the founding editor-in-chief.

The #IBEX Knowledge-Base is an exciting initiative promoting open science and collaboration for immunofluorescence multiplexed imaging! New to this wonderful community and excited for the research ahead! Find out more 👇🏾

The @alexyema.bsky.social lab and colleagues show that dominant negative variants in ITPR3 impair T cell Ca²⁺ dynamics causing combined immunodeficiency. rupress.org/jem/article/...

📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025

Very grateful to have been introduced to the wonderful #IBEX Knowledge-Base community 👇🏾 and to this novel spatial proteomics technique. Looking forward to more multiplexed imaging!

1/ I am both delighted and relieved to share my inaugural editorial for the @jhumimmunity.org
rupress.org/jhi/article/...

Unjustified silence in the face of this new war in eastern DR Congo Since Jan 23, 2025, the rebel March 23 Movement (M23), with the support of Rwanda, has launched an offensive in eastern Democratic Republic of the Congo, further exacerbating the region's ongoing conf...

Unjustified silence in the face of this new war in eastern DR Congo
"Inaction implies resignation to the idea that the survival of the fittest governs the world's fate"

Correspondence in @thelancet.bsky.social

www.thelancet.com/journals/lan...

Our clinical experience using ex vivo T-lymphopoiesis assays to assist clinical decision-making between #HCT for #SCID & #thymus transplantation for #athymia in genetically undefined T-lymphocytopaenia is published 👉 doi.org/10.1016/j.cl...

Thank you to all collaborators and referring clinicians!

Journal of Human Immunity (JHI) @jhumimmunity.org is here! Read the inaugural editorial by @casanovalab.bsky.social outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. https://buff.ly/4hRGpOb
#OpenAccess

Our thymus, a critical source and trainer of T cells, involutes with aging. 2 new studies find a growth factor (FGF21) that delays involution (in mouse models) and may be a way to rejuvenate our immune system and promote healthy aging in the future.

For the full story 👉 doi.org/10.1084/jem....

Delighted & proud that this wonderful collection in @jem.org includes our study characterising dominant negative variants in ITPR3 in syndromic combined immunodeficiency patients due to calcium channel leakiness of the IP3 receptor, causing ER Ca2+ store depletion and impaired Ca2+ T cell dynamics.

A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.

Auschwitz was at the end of a long process. It did not start from gas chambers.

This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.

Auschwitz took time.

Welcome to the future of #HumanImmunity research! @rupress.org and the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) are launching the Journal of Human Immunity (JHI)! Stay tuned for groundbreaking, #OpenAccess research! 👉 https://buff.ly/4ajqm8W

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? A new study shows that some of our cells favor genes of one parent or the other and can explain a longstanding mystery of why some people with disease-causing genes experience no symptoms.

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)?
Latest from us. Published today. News here www.cuimc.columbia.edu/news/what-ha... article here: www.nature.com/articles/s41... @stewart_ojay @BogunovicLab and a huge international team thank you 🙏🏼

👏👏👏

European Society for Immunodeficiencies guidelines for the management of patients with congenital athymia Congenital athymia is a life-limiting disorder due to rare inborn errors of immunity causing impaired thymus organogenesis or abnormal thymic stromal …

On behalf of @ESIDsociety clinical working party, we have written guidelines with clinical practice recommendations focused on the diagnosis, investigation, risk stratification, and management of congenital #athymia with the aim to improve patient outcomes. Out now in @jacionline: bit.ly/4g4qkUs

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

last 2 days to apply! : We have a fully funded #PhD #studentship available in my lab for Oct25 @UCLchildhealth. Project will research new treatments/targets for airway inflammation during viral infection using complex in vitro models. Deadline 13th Dec
Apply here: forms.office.com/pages/respon...

We are thrilled to announce that Prof. Claudia Mauri will join Clinical & Experimental Immunology (CEI) as Editor-in-Chief from January 2025 🎊

Find out more and hear about Prof. Mauri's plans for the journal here👉 www.immunology.org/news/welcome...

RANKL treatment restores thymic function and improves T cell–mediated immune responses in aged mice RANK ligand administration reversed age-dependent thymic involution and rejuvenated T cell immunity in mice.

Excited to share our 1st post ! Thrilled to share our latest research in Science Translational Medicine ! @science.org
We show that RANKL administration reverses thymic involution and rejuvenates T cell immunity.
@ciml.bsky.social
#Aging #Thymus #Tcells #Immunology #Involution #Rejuvenation

Hi Neil, would love to be added! 🙋🏾‍♀️ Thank you

go.bsky.app/L7XhT8H

Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows

Know a #devbio post-doc about to enter the academic job market?

Would they benefit from a little support & mentoring?

Spread the word

Deadline 31 Jan 2025

journals.biologists.com/dev/pages/pi...

A spatial human thymus cell atlas mapped to a continuous tissue axis - Nature A quantitative morphological framework for the human thymus reveals the establishment of the lobular cytokine network, canonical thymocyte trajectories and thymic epithelial cell distributions in...

🚨Out now in Nature: Our spatial atlas of the developing thymus nature.com/articles/s41...
Together with the labs of Sarah Teichmann, Ron Germain & John Marioni we present insights into the establishment of the thymic organ structure in pre- and postnatal life through a new spatial mapping approach.

single cell RNAseq data showing shifts in fibroblast phenotypes after genetic deletion of Podoplanin in lymph node stroma.

Our latest preprint! - led by @makris1.bsky.social
we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations
doi.org/10.1101/2022...