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Miron Lab

@mironlab.bsky.social

Lab @ Unity Health Toronto/University of Toronto & UK Dementia Research Institute/ University of Edinburgh studying myelin health across the lifespan. John David Eaton Chair of MS Research/ MRC Senior Fellow www.mironlab.ca

1,270 Followers  |  450 Following  |  54 Posts  |  Joined: 14.11.2024  |  1.757

Latest posts by mironlab.bsky.social on Bluesky

Careers | Department of Cellular & Physiological Sciences

Our department at The University of British Columbia in Vancouver (Canada) is running two faculty searches. One is a joint hire with the Institute for Healthy Aging, one a cohire with the Math Dept cps.med.ubc.ca/careers-2/ Click on β€œFaculty Positions” on the page. Please help spread the word!

30.07.2025 17:11 β€” πŸ‘ 33    πŸ” 40    πŸ’¬ 1    πŸ“Œ 2
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Seventeen research projects based at Unity Health Toronto have been awarded more than $17.5 million in funding from the Canadian Institutes of Health Research | Instituts de recherche en santΓ© du… | U... Seventeen research projects based at Unity Health Toronto have been awarded more than $17.5 million in funding from the Canadian Institutes of Health Research | Instituts de recherche en santΓ© du Cana...

Seventeen research projects at Unity Health have been awarded more than $17.5M from CIHR's 2025 spring project grant program. Congratulations to all of the scientists and teams who received funding to advance their innovative projects! Learn more: lnkd.in/g5XXfpUU

24.07.2025 16:26 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1

You... can provide input directly to the federal government, right now.
#cdnpoli

16.07.2025 10:48 β€” πŸ‘ 12    πŸ” 19    πŸ’¬ 3    πŸ“Œ 24

Congrats! Lol about the budget decapitation fairy, which I did not believe in until today....

17.07.2025 15:51 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We are thrilled to receive our first #CIHR project grant to investigate white matter changes driving cognitive decline in aging! Huge thanks to our superstar postdoc Georgie who is driving the project, all the colleagues who gave great feedback, and the reviewers for supporting the proposal.

17.07.2025 11:57 β€” πŸ‘ 38    πŸ” 3    πŸ’¬ 4    πŸ“Œ 0
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If you're attending @gliameeting.bsky.social #glia2025 check out Lucy Ryan's talk in the trainee symposia (17) on Thursday & poster T14-001A on heterogeneity of oligodendrocyte pathology in Alzheimer's disease!

06.07.2025 14:00 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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If you're attending @gliameeting.bsky.social #glia2025 check out Lucy Ryan's talk in the trainee symposia (17) on Thursday & poster T14-001A on heterogeneity of oligodendrocyte pathology in Alzheimer's disease!

06.07.2025 14:00 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

25.06.2025 14:56 β€” πŸ‘ 261    πŸ” 263    πŸ’¬ 1    πŸ“Œ 14
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Very proud of Jonathan for winning an oral presentation prize at the Toronto wide neuroscience program (CPIN) research day this week! πŸŽ‰πŸŽ‰πŸŽ‰

26.06.2025 11:16 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Come and join us! Start your group at Karolinska Institutet @ki.se!

18.06.2025 17:19 β€” πŸ‘ 18    πŸ” 15    πŸ’¬ 1    πŸ“Œ 1
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Assistant or associate professor-researcher in Neuroscience related to neurological disorders and/or neural regeneration and precision health DescriptionΒ  The Neuroscience Research Axis of the CRCHUM and the Department of Neuroscience of the UdeM are inviting applications for a position of assistant or associate professor-researcher in neur...

Call for an Assistant / Associate Prof. just opened at the @crchum.bsky.social in the Neuroscience Axis !

www.chumontreal.qc.ca/en/emplois/a...

13.06.2025 13:56 β€” πŸ‘ 24    πŸ” 23    πŸ’¬ 0    πŸ“Œ 0
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Really enjoyed @keystonesymposia.bsky.social #KSNeuroimmune25 & #KSNeurodegen25 , with Jonathan & I presenting new stories on oligodendrocytes being bad 😁 Big thanks for Jonathan's travel award, and to all the chairs for an exciting meeting

12.06.2025 21:11 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Congrats to Bianca Hill for passing her qualifying exam with flying colours, and is now officially a PhD candidate! πŸŽ‰

04.06.2025 19:20 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Happy Pride Month! Thrilled that I've always worked, and continue to work in, diverse research communities that are based on respect πŸ³οΈβ€πŸŒˆ

03.06.2025 12:53 β€” πŸ‘ 9    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Really enjoyed all the impressive trainee talks and posters at @unityhealthto.bsky.social research day & very proud of Jonathan for winning best oral presentation! He's on a roll πŸ’ͺ

27.05.2025 21:12 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Jonathan & I really enjoyed covering this tour-de-force paper by @janos-groh.bsky.social & Mika Simons as a News & Views for @natneuro.nature.com, demonstrating a deleterious role for white matter associated microglia in recruiting pro-neurodegeneration T cells in aging. Check it out below!

24.05.2025 16:59 β€” πŸ‘ 12    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Microglia conduct the symphony of white matter degeneration in aging through T cell recruitment - Nature Neuroscience Aging induces pathological changes in central nervous system (CNS) myelin, which in turn induce microglia dysregulation. What is the consequence of this microglial response on white matter pathology i...

See also this excellent News & Views from Jonathan Monteiro and Veronique Miron @mironlab.bsky.social.
www.nature.com/articles/s41...

22.05.2025 10:39 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Was so impressed with the exciting glia research going on across Canada showcased at #CANglia yesterday. Especially proud of Jonathan Monteiro for chairing a session & Georgie Craig for winning best oral presentation by a senior trainee!

21.05.2025 11:05 β€” πŸ‘ 16    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Had a lovely time visiting the University of Manitoba yesterday (despite the weather) and hearing about all the interesting science, but most of all impressed by how nice everyone is! Thank you to Soheila Karimi for being a wonderful host

16.05.2025 14:10 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Grateful to ACTRIMS for hosting our PhD students Jonathan & Bianca for the Young Scientist Summit last week, and very proud of Jonathan for winning the poster prize!

14.05.2025 16:13 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Canadian Association for Neuroscience Conference Childcare, Dependent, or Disability Care Subsidy – Canadian Association for Neuroscience

As the Canadian Association for Neuroscience meeting approaches, we are still offering subsidies for Childcare, Dependent, or Disability Care.
Please apply or share with others who may benefit: can-acn.org/meeting-2025...

09.05.2025 12:32 β€” πŸ‘ 8    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

09.05.2025 08:33 β€” πŸ‘ 10    πŸ” 11    πŸ’¬ 0    πŸ“Œ 1

Do you have multiple sclerosis (MS) or are you the family member of someone with MS? Dr. Marrie, a researcher at NS Health, is doing a research study to find out how future MS research should take account of equity, diversity and inclusion. For more information: msresearch.ca/study/priori...

09.05.2025 13:27 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Professor, Senior Lecturer/Lecturer and Lecturer posts - Glasgow City (GB) job with University of Glasgow | 12838283 University of Glasgow College of Medical, Veterinary and Life SciencesΒ  School of Psychology & Neuroscience Professor in Cognitive Neuroscience/Psy...

Brain/behaviour people - come to beautiful Scotland - we are recruiting in psychology and neuroscience across all grades! Closes May 12. Details below, and please re-post πŸ™

www.nature.com/naturecareer...

More about us here: www.gla.ac.uk/schools/psyc...

#neuroskyence #neurojobs

08.05.2025 07:04 β€” πŸ‘ 47    πŸ” 45    πŸ’¬ 1    πŸ“Œ 1

Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...

05.05.2025 22:47 β€” πŸ‘ 72    πŸ” 57    πŸ’¬ 0    πŸ“Œ 5

β€œHow might the narrative about senior women be challenged or changed in order to respect these women who have achieved enough success to earn promotion? How do we stop this generational cycle so that women's wings aren't clipped as soon as they approach the power to soar.”

03.05.2025 14:06 β€” πŸ‘ 107    πŸ” 32    πŸ’¬ 6    πŸ“Œ 8

If you're at #BNA2025 check out @cmbneuro.bsky.social 's poster using spatial transcriptomics to identify mechanisms of human white matter vulnerability in Alzheimer's disease!

27.04.2025 22:56 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 2    πŸ“Œ 0
Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 ΞΌm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 ΞΌm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

Top left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Csf1r-iCre;Porcfl/fl compared to Porcfl/fl control mice at 14 dpl, counterstained with Hoechst. Scale bar, 20 ΞΌm. Bottom left: Representative immunofluorescent labeling of oligodendrocyte lineage cells (Olig2+, green) which are mature (CC1+, magenta) in Vehicle-treated and C59-treated monocyte transplanted mice at 10 dpl, counterstained with Hoechst. Scale bar, 20 ΞΌm. Right: Graphical abstract of results: Classical monocytes support oligodendrocyte differentiation and myelin protein expression, yet impede myelin production during remyelination in a Wnt-dependent manner.

#Remyelination in the CNS is influenced by myeloid cells, including resident #microglia & infiltrating #monocytes. @mironlab.bsky.social &co show that infiltrating monocytes inhibit the efficiency of CNS remyelination @plosbiology.org πŸ§ͺ plos.io/3RryCLF

22.04.2025 17:21 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
AURORA - Your Blood
YouTube video by iamAURORAVEVO AURORA - Your Blood

Thanks to all our collaborators, and funders @mssocietyuk.bsky.social & St Michael's Hospital Foundation in Toronto (John David Eaton Chair & Hall-Sloan Basic Science Research Fund).
Paper soundtrack Your Blood by Aurora: youtu.be/_kVSFFaD5io?...

22.04.2025 21:43 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Relevance to MS:
1. Wnt signature in monocytes in both mouse lesions & MS mixed lesions
2. Wnt signature increased in blood monocytes in people with MS with high vs low disability
3. Inhibiting Wnt release from monocytes genetically or pharmacologically enhanced remyelination in mice

22.04.2025 21:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

@mironlab is following 20 prominent accounts