Jeyakumar Meyyappan

Sometimes more lessons are learned from failures than successes. I've learned quite a bit from working through the challenges of this trial. #NephJC

The HiLo Trial - Visual Abstract — NephJC Is a lower versus higher phosphate target beneficial to patients undergoing hemodialysis? Check out this crisp VA by Dr Sejal Lakhani

😎Check out the VA for HiLO by @sejalplakhani.bsky.social
🆒 This should be quite the discussion, don't miss it!
#NephJC #NephSky
www.nephjc.com/news/2025/8/4/the-hilo-trial-visual-abstract

High or Low Phosphate? Are we Missing the (P)oint? — NephJC This week, we will discuss the phosphate targets in dialysis. Are you aiming for HIgh or Low?

HiLo, HiLo it's off to work we go! ⛏️
Join us 9 pm EST 8/5/25 to discuss. #NephJC #NephSky
Controlling Phos in patients on HD is a lot of work, but is it worth it? HiLo looks at hospitalization & death in low/high Phos goals. Will we finally have a RCT with answers ⁉️
www.nephjc.com/news/hilo-tr...

Severe AKI in the ICU: Management ca. 2025
#Nephpearls #AKIinICU #NephSky

👉🏼 pubmed.ncbi.nlm.nih.gov/40578821/

#nephjc
Hello all ,
Jeyakumar from India .
I stick to creatinine for most decisions.
Would love to know about the gap though

Great job Marc @msocomd.bsky.social . :) #NephJC

Agree. The trial meant to see if starting agents upfront can make adifference. The point is these patients anyway wud have started the other pillars in sequence if made available. UACR (already < 1 gram ) & its reduction by 52% not strong point to start 2gether. Can still go in sequence #NephJC

The next trial should measure hard outcomes like mortality and ESKD.
Albuminuria reduction and the eGFR are dip were expected and go hand in hand. #NephJC.

Also the reason why they must have had screening failure of more than 50 percent .
In reality , I don’t mind if my patient s eGFR was more than 45 and his potassium is 5.5.
Would just Flozinate and be happy.
#NephJC

My approach with the #nsmra when egfr less than 45-50 ie #flozin first. If egfr over 45 start both at the same time because #YOLO

#Nephjc

98% on ACEi /ARB and still have potassium less than 4.8 . Not what we see always #NephJC

SGLT2 also phylogenetically an older system than RASi #NephJC

#NephJC

I think 30 mg /day will be where we are headed. ( The Push just like how lipid targets in CVD kept getting lower) #NephJC. But 500 mg/day for now

Thank you Swap. With plenty of help from the NephJC faculty . Thanks to you and all of them . I am more CONFIDENT #NephJC

#NephJC

Hello all.
This is Jeyakumar from Lucknow.
No COI

A dose of CONFIDENCE: Building evidence for finerenone-empagliflozin synergy in diabetic kidney disease — NephJC This week, we will discuss how the CONFIDENCE trial gets nephrology closer to the magic CKD polypill of CKD.

With unshakable CONFIDENCE, finerenone and empagliflozin waltz into diabetic kidney disease - turning 'maybe someday' into 'why not today?'

#NephJC summary by @sejalplakhani.bsky.social and @jeyakumarmeyyappan.bsky.social

#MedSky

www.nephjc.com/news/confide...

A dose of CONFIDENCE: Building evidence for finerenone-empagliflozin synergy in diabetic kidney disease — NephJC This week, we will discuss how the CONFIDENCE trial gets nephrology closer to the magic CKD polypill of CKD.

Check out the blog summary . CONFIDENCE
How confident are we starting sglt 2 i + nsmra upfront for patients with diabetes and kidney diseases ?
www.nephjc.com/news/confide...

Check out the latest KDIGO Direct: kdigo.co/KDIGO-Direct...
In this issue:
📗 Nephrotic Syndrome in Children GL publishes
📢 Dr. Wanner elected KDIGO Co-Chair
💔 KDIGO mourns Dr. Rinaldo Bellomo
🌍 KDIGO convenes Green Dialysis Conference
🏛️ KDIGO at #ERA25
🎥 New resources on #ADPKD, #C3G, #CKM & #IgAN

Desmopressin for kidney biopsy - The Visual abstract — NephJC Does desmopressin reduce the risjk of post kidney biopsy bleeding? Checkout the beautiful VA answering this practical question by NSMC faculty Dr Divya Bajpai

👋Want to get my attention...start bleeding 🩸
Hey #NephSky #NephJC fans!
Check out the VA on ddAVP and kidney biopsy bleeding for tonite's discussion on #bluesky at 9pm by Dr. Divya Bajpai
www.nephjc.com/news/2025/5/13/desmopressin-for-kidney-biopsy-the-visual-abstract