Congratulations to Dr. Katerina Kiriakopulos and all co-workers! Tremendous efforts finalize a great story about a lncRNA driving a really important biological process.
16.12.2025 19:27 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
CISTRโs DNA and RNA have function. NuRD complex components bind CISTRโs locus, whilst transcription factor FOSL2 associates with CISTRโs RNA. In CISTRโs absence, FOSL2 is misguided which leads to differential regulation of cell morphogenesis genes and aberrant cell size.
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CISTR-ACT maintains cell size across cell types in human and mice by regulating cell morphogenesis genes in trans via guidance of the transcription factor FOSL2.
16.12.2025 19:27 โ ๐ 0 ๐ 0 ๐ฌ 1 ๐ 0
https://www.nature.com/articles/s41467-025-67591-x
CISTR-ACT was the 1st lncRNA involved in inter-chromosomal contacts and in Mendelian disease (brachydactyly). We now revealed CISTR-ACTโs molecular mechanism: tinyurl.com/CISTR-ACT, @sickkidsto.bsky.social, @uoftpress.bsky.social, @natcomms.nature.com, @natureportfolio.nature.com
16.12.2025 19:27 โ ๐ 1 ๐ 1 ๐ฌ 1 ๐ 0
tRNA-overlapping long non-coding RNA loci repress codon-biased genes
Ahmed et al. define tRNA-overlapping lncRNAs (tROLs). tROLs in gene-dense regions
interact between chromosomes and depend on each otherโs transcription. tROL perturbations
silence codon-biased genes i...
๐ข Paper Alert: tinyurl.com/yzy2d864. We characterized tRNA-overlapping lncRNA loci = tROLs! tROL perturbations silence
codon-biased genes in inter-chromosomal proximity. tROLs bridge the non-coding
and coding genomes. @sickkidsto.bsky.social @uoftpress.bsky.social
14.10.2025 14:33 โ ๐ 6 ๐ 3 ๐ฌ 0 ๐ 0
Register now and see you soon in Mexico for a great conference and speaker line up!
03.09.2025 00:41 โ ๐ 0 ๐ 0 ๐ฌ 0 ๐ 0
One of the world's best children's hospitals: The Hospital for Sick Children (SickKids) in Toronto. Our vision: Healthier Children. A Better World.โข
David Bartel's lab @WhiteheadInst @MIT @HHMI | microRNAs, mRNAs, and other RNAs
Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. Part of @natureportfolio.bsky.social
Repost/like=interesting/relevant, not necessarily endorsement.
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Independent Junior Group Leader at TUM - Postdoc in the Rinn & Meissner Lab (Harvard) - PhD in Denise Barlow's lab (CeMM)
We develop (non-coding) RNA therapeutics for incurable diseases using genomics and bioinformatics. PI: Rory Johnson
Scientist, mostly interested in genetics, lncRNAs and .... well, in everything that I deem relevant. (he/him), find me at https://georg-speyer-haus.de/en/
Cardiac developmental biologist. Oakland and San Francisco. Hi friends! ๐จ๐ฆ
Prof at Cornell, #firstgen, immigrant ๐ซ๐ท๐บ๐ธ. Transposons, viruses, and all the cool stuff genomes are made of. https://www.feschottelab.com
Independent research group leader @GoetheUni. PhD in Biomedicine. Non-coding genome, RNA biology & localization.
www.gdumboviclab.org/
Parent, scientist (zebrafish heart development), struggling athlete, lover of board games and RPGs.
The European Molecular Biology Laboratory drives visionary basic research and technology development in the life sciences. www.embl.org
EMBL's European Bioinformatics Institute (EMBL-EBI) provides open biological data resources and tools, and performs basic research in computational biology. https://www.ebi.ac.uk/
Research Group Leader at FMI, Switzerland | Expert in Gene Expression | Cycling Enthusiast & Rock Climber
Find me on X as @MarcBhler4 or instagram.com/maggi.buehler
๐ฌ๐พ๐จ๐ฆAssistant Professor @uoft.bsky.social Biochemistry, studying the forms and functions of genome organization during development. Canada Research Chair in 4D Genomics. https://sawhlab.netlify.app/
Postdoc @MCB_Harvard/@Biozentrum; PhD @McGillU
Physician-scientist & CSO @Amgen. Passionate about RNA, epigenomics & decoding gene regulation. Former HHMI Investigator & Stanford Prof. Building teams to solve biologyโs hardest problems & translate genomics into transformative medicines.
Molecular biologist interested in non-coding RNAs, nuclear organization, and gene regulation. Professor at Caltech
Looking at genomes with 3D glasses as part of http://marciuslab.org.
President of @SCB.iec.cat
Proud member of @icreacommunity.bsky.social.
Happy at @CNAG-eu.bsky.social and @CRG.eu in Barcelona.
#4DNucleome #3Dgenomics #microbiome #biogeography
Signal transduction, systems biology and proteomics lab focusing on cancer @Lunenfeld-Tanenbaum Research Institute (LTRI), Sinai Health, Toronto, https://gingraslab.org. (Anne-Claude is also VP of Research @ Sinai Health) #TeamMassSpec
