The FEBS Journal

🔦 We are pleased to spotlight our November Editor's Choice article from our Immunity and Inflammation focus issue

📗 Melanoma cells suppress mast cell function via a melanin‐dependent mechanism

Discover the Open Access article, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

🔬 We are pleased to share this new article from our Immunity and Inflammation focus issue

📗 Nanoscale engagement of programmed death ligand 1 (PD-L1) in membrane lipid raft domains of cancer cells

Discover the article, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

Sadly we are unable to attend the @britsocimm.bsky.social 2025 Congress #BSI25 this year but we hope to be back in 2026!

We have some great #immunology content recently published within our Immunity and Inflammation focus issue ➡️ febs.onlinelibrary.wiley.com/toc/17424658... Go check it out! 📖

📣 Publication alert: Our paper, “A guide to building the matrisome interactome: from computational predictions to experimental validation” is now published in @febsj.bsky.social!
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology

FEBS Press The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth-promoting rhizobacteria play crucial roles in agric...

A small contribution from us & Edi Gerhardt @febsj.bsky.social

Highlighting the recent findings: Structure of the NifL-NifA complex controlling nitrogen fixation gene expression in Azotobacter

febs.onlinelibrary.wiley.com/doi/10.1111/...
@sfb1381.bsky.social @hhu.de @mibinet.bsky.social

The original publication:

Structural analysis of the NifL-NifA complex reveals the molecular basis of anti-activation of nitrogen fixation gene expression in Azotobacter vinelandii
@febsj.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Nitrate from food is first converted to nitrite by oral bacteria and then further processed in the intestine. The gut microbiota reduces nitrate and nitrite to ammonia or nitric oxide, preventing the....

Distribution and activity of nitrate and nitrite reductases in the microbiota of the human intestinal tract
#biochemistry #GutMicrobiota
@febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...

Paper by the Schneider lab( @schneian.bsky.social ) & collaborators w/co-first authors Corinne von Känel & Salome Aeschlimann "TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome" @febsj.bsky.social nccr-rna-and-disease.ch/news/article...

Interested in a career in scientific publishing?

Gain valuable publishing insights with a 3-month remote placement at @febsj.bsky.social @moloncology.bsky.social & a visit to the Heidelberg office 🌍

Apply by 06 Nov 2025 for an EACR-Molecular Oncology Editorial Fellowship: eacr.org/eacr-molecul...

FEBS Press The bacterial dynamin-like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane associat....

Binding of Bacillus subtilis dynamin-like protein DynA to the bacterial membrane is essential for effective phage defense

@febsj.bsky.social from @bramkamplab.bsky.social

febs.onlinelibrary.wiley.com/doi/10.1111/...

📗 The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis

Read the article from our Disease Mechanisms focus issue ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism dr...

We are pleased to spotlight a new #OA article from our Disease Mechanisms focus issue

🧠 Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

Read here ➡️
febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Phylogenetic analyses of glutamine synthetase (GS) in seed plants revealed that all three major evolutionary lineages (GS2, GS1a, and GS1b) must have been present in the common ancestor, with GS2 bei....

Phylogenetic reconciliation provides new insights into the evolutionary diversification of the glutamine synthetase gene family in seed plants febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social

We are proud to share this new State-of-the-Art-Review from our recent Structural Insights into Disease Mechanisms focus issue 🪰🧪

📗 In vivo and in silico models of #drosophila for #parkinsonsdisease

Read the review #openaccess here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l...

Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....

Excited that our work led by the Dere Lab is now published! This study is the first to identify KDM4A as a centrosome protein, revealing its chromatin-independent function in maintaining centrosome integrity and genomic stability!
#microscopy #nanoscale @febsj.bsky.social
doi.org/10.1111/febs...

FEBS Press In this issue of The FEBS Journal, we interviewed Małgorzata ‘Gosia’ Kosla, who together with her husband Piotr, established the PACS2 Research Foundation when their daughter Lena was diagnosed with ...

🩺 Małgorzata Kosla and her husband Piotr established the PACS2 Research Foundation when their daughter was diagnosed with this ultrarare syndrome.

Read the interview with FEBSJ Editor @hajrah-khawaja.bsky.social and Malgorzata Kosla, here ➡️ febs.onlinelibrary.wiley.com/doi/10.1111/...

Our Disease Mechanisms Focus Issue is out now 📗🪰 febs.onlinelibrary.wiley.com/toc/17424658...

Articles combine fundamental structural insight with mechanistic implications for disease, reinforcing how structural information is essential for unravelling the basis and guiding therapeutic strategies.

Excited to share our new paper in @febsj.bsky.social! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs...
@peterslab1.bsky.social

FEBS Press A plant homeodomain (PHD) at the C terminus of additional sex combs-like (ASXL) proteins is recurrently truncated in disease. In the current study, the ASXL PHD was shown not to bind histone modifica...

Excited to see this work led by Cameron Reddington and Annabel Walsh out in @febsj.bsky.social — ASXL proteins share a PHD domain that is not a PHD domain, evolved to bind an MBD domain that is not an MBD domain!

febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Ferredoxin-dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyano...

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer febs.onlinelibrary.wiley.com/doi/10.1111/... @febsj.bsky.social

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

🩸 Register today for the FEBS Workshop on Aging in Hematopoiesis that will take place in ☀️ Crete on October 20-24, 2025!

🩸 An outstanding scientific program in a beautiful location! More info: buff.ly/bSHhzR3

⏱️ ONE WEEK LEFT!
Travel Grants available for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24, 2025!
Phenomenal speakers, beautiful location & lots of opportunities to network!

⏱️ Deadline for applications: July 31. To apply ▶️: buff.ly/C1Ar5Sx

Very happy that our SIAH1 article - published online in February - was now chosen for the cover of the new issue of the @febsj.bsky.social . Thank you @spartelab.bsky.social for the wonderful collaboration and the lovely cellular images. febs.onlinelibrary.wiley.com/toc/17424658...

🍬 Looking for #WeekendReads?
Our latest issue is ready!

🍬 #CancerMetabolism takes centre-stage in our Reviews section
🕸️ A new Viewpoint discusses #ECM preparations' effects on the environment
📰 Rich crop of #MolecularLifeSicences research articles

🍬 buff.ly/wRbis26

FEBS Press Recent insights reveal that type I interferon (IFN-I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN-I activity is increasingly linked to neurologica...

New review out with Aysha in @febsj.bsky.social. We discuss how dysregulated type-I interferon signalling affects brain function, with a focus on the IFN-responsive state of microglia. Experimental work coming soon, stay tuned! febs.onlinelibrary.wiley.com/doi/10.1111/...

FEBS Press Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found t...

Now published @febsj.bsky.social @febspress.bsky.social

--> doi.org/10.1111/febs...

🧬 @febspress.bsky.social is hiring!

Join The FEBS Journal as a full-time Editor 📚

🌍 Fully remote, UK-based, permanent role
📅 Deadline: 31 May 2025
📩 Send your CV, cover letter, and a 200-word research highlight to: ruffell@febs.org

Learn more ➡️ febs.org/news/jobs-po...

FEBS Press The unfolded protein response (UPR) is engaged by perturbations of protein folding in the endoplasmic reticulum (ER). Here, we compile evidence that the UPR is activated by physiological and patholog...

A reviewer asked: but why is IRE1 activated when glucose is low?
A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation?
So we wrote a review about it.
Here it is!
@ericchevet.bsky.social @febsj.bsky.social
febs.onlinelibrary.wiley.com/doi/10.1111/...