Yasmin Dabiri

Pancreatic cancer relies on opposing signalling pathways to drive its cellular diversity Communication between epithelial and mesenchymal cells in pancreatic cancer leads to a poor prognosis. The molecular basis for this signalling has now been revealed.

new out in Nature, a News & Views www.nature.com/articles/d41...

Registration for Cancer Cell Plasticity closes on Monday 03 November!

Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels:

eacr.org/conference/c...

Exciting study from @batllelab.bsky.social, showing a new “cell trajectory” (EMP1-positive to LGR5-positive) underpinning RAS inhibition in pre-clinical models of metastatic CRC. The rapid re-population of CRC organoids with Lgr5-positive stem cells upon RMC-9945 treatment is super cool!! 👏🏻

Many congrats, Katharina!! Officially, the senior author 😊

Identification, functional insights and therapeutic targeting of EMT tumour states - Nature Reviews Cancer In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.

It is now know that #EMT is not a simple binary switch but occurs through a series of different tumour states. In this Review, Dong and Blanplain discuss this and the pharmacological implications for targeting EMT to overcome therapy resistance.

Exciting study on paracrine regulation of EMT plasticity in PDAC, showing the critical role of soluble factors, SPP1 and Gremlin1. 👏🏻 @nature.com

PhD position available in my group in Frankfurt. Explore adaptive immune responses in metastatic colorectal cancer using multi-omics and AIRR profiling. #TRR417 @loewe-fci.bsky.social

georg-speyer-haus.de/karriere/ste...

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

elegant study, on the use of CAFs’ intrinsic vulnerabilities to overcome the immune-suppressive TME, enhancing anti-tumour immunity.

Endoplasmic reticulum stress responses in anticancer immunity - Nature Reviews Cancer The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the function of intratumoural immune cells and the efficacy of immunotherapy, highlighting the potential of unfolded protein response-targeted interventions to improve cancer outcomes.

REVIEW🚨

Rodriguez, Cubillos-Ruiz &Co discuss how the #ERstress response affects intratumoural immune cells & highlight the potential of #UPR-targeted interventions to improve cancer outcomes.

👀⬇️

Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

new out in Nature, a really cool study www.nature.com/articles/s41...

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social‬
www.nature.com/articles/s41...

The mysterious stem cells that could hold the key to beating bowel cancer - Cancer Research UK - Cancer News Using organoids, researchers have found that 'revival' stem cells could hold the key to why people's cancers respond differently to treatment

Thanks to @cancerresearchuk.org for featuring our work on stem cell plasticity in CRC: news.cancerresearchuk.org/2025/05/09/s...

We are recruiting for a new Research Technician to join the @cruk-cityoflondon.bsky.social Organoid Platform!

Full details at: www.ucl.ac.uk/work-at-ucl/...

YouTube video by yEFIS yEFIS Women in Immunology: Interview with Professor Johanna Joyce

Many thanks to the young immunologists of @yefis-immunology.bsky.social for this interview as part of their #WomeninSTEM 🧪 series!

Really enjoyed discussing ways to improve #gender #equality and all forms of #inclusion & #diversity - esp. important now 🙏

Interview 🎥
www.youtube.com/watch?v=4CRx...

#ResearchHighlight 🚨

The #PROTAC 753b, which targets BCL-xL and BCL-2 to the E3 ligase VHL can remove #senescent cells specifically from the liver of mice, reducing the progression of chronic metabolic liver disease to liver cancer.
#senolytics @uthealthbarshop.bsky.social‬

Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status - Journal of Experimental & Clinical Cancer Research Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential...

New paper online on Head and Neck Cancer Organoids. Congrats to Christian and the entire team who contributed

jeccr.biomedcentral.com/articles/10....

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity.

www.nature.com/articles/s41...

Join iHOME 2025 (Mar 20–21 in Heidelberg) for cutting-edge organoid research spanning basic to clinical science! One of many highlights is the keynote speaker, Barbara Treutlein, ETH Zurich, discussing using single-cell tech to map organoid development. Register by Feb 28: indico.dkfz.de/event/1249/

We are recruiting for a Senior Scientific Officer to work with @npentinmikko.bsky.social in Owen Sansom's lab investigating cell interactions during tumour initiation and regeneration

📅Closing date: 31 January 2025

🔗Find out more and apply here: www.crukscotlandinstitute.ac.uk/careers/scie...

Among nearly 35,000 biological scientists who authored their first paper in 2000, women were more likely than men to have stopped publishing after 5, 10 or 20 years. The size of this gender gap varies between disciplines.

Disappointing new study showing - once again - that women are leaving research careers at far higher levels than men

If you're interested to read about strategies to reverse these types of curves, check out our recent #Cell perspective- link below ⤵️

#WomeninSTEM 👩‍🔬👩🏾‍🔬🧪

www.nature.com/articles/d41...

indeed if we (you!) could come up with a set of distinguished markers is very useful and clinically-relevant! Congrats again 👏🏻

Massive congrats to Shania, Svetlana & Noha (not on Bsky) identifying the mechanistic and phenotype cascades underpinning the anti-metastatic response triggered by viral mimicry

TLDR; aggressive CMS4 tumours can be reprogrammed towards less aggressive CMS1

biorxiv.org/content/10.1...

thread 👇

Congrats, very interesting, have to read carefully-but then the good RSCs are induced by an inflammatory niche? and any specific marker for them?

#Colorectal #Cancer #Starterpack.
Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer.
Please comment/text to be added!
go.bsky.app/PGqU6zP

The #intestine's dynamics (environment/movement/stiffness/flow) shapes stem cell fitness and function, shown here via PIEZO channels and is reflected in in-vitro models. So, are static 3D cultures sufficient? Could microphysiological systems #MPS #Organ-on-chip offer a better approach here?