Kenji Sugioka

Cadherin flow translates cortical chirality into left-right asymmetric cell division dynamics in Caenorhabditis elegans embryos Khor et al. show that cadherin, a major adhesion molecule in animals, undergoes sequential polarized flows in Caenorhabditis elegans embryos. These flows establish a chiral cell-cell adhesion pattern ...

Adding another link. www.cell.com/current-biol... #Devbio

The work was spearheaded by MSc student Mi Jing Khor, with support from PhD candidate Yuxuan Rain Xiong and undergrad Gagan Sangha.

The established chiral cadherin patch interacts asymmetrically with the contractile ring, likely driving its rightward closure, the first detectable left–right asymmetry in C. elegans.

We showed that both ventral and left–right asymmetric cadherin flows are required to generate a chiral cadherin patch pattern.

We found that cadherin at cell–cell contacts exhibits two distinct flows, such as ventral flow and left–right asymmetric flow, each driven by ECM and RhoA signaling (left movie). The resulting cadherin patch pattern is chiral, meaning it cannot be superimposed on its mirror image

Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis - Nature Communications Contractile ring formation, positioning, and closure is influenced by tissue mechanics, though how this information is transmitted is unclear. Here they show that Anillin is critical for a mechanosens...

We used the 2nd mitosis of C. elegans as a model system, which shows both chiral cortical dynamics and L-R asymmetric closure of the contractile ring. Our past study shows that cell adhesion drives asymmetric ring closure in this cell type. www.nature.com/articles/s41...

New paper from the lab! Many animal cells exhibit chiral cell surface dynamics, which are proposed to drive left–right asymmetric patterning. However, the molecular mechanisms linking these events remain unclear. authors.elsevier.com/a/1l%7E7B3QW...