Centromeres, polyploidy, carnivorous plant, instant bookmark.
28.07.2025 12:37 β π 10 π 1 π¬ 0 π 0
#ERGAReads | Analysis of 3 pentaploid dogrose genomes provide insights into their unique reproductive strategies & advance our understanding of genome #evolution and meiotic mechanisms in organisms with asymmetrical inheritance systems π΅οΈ
π www.nature.com/articles/s41...
@sgn.one @ceplas.bsky.social
09.07.2025 08:56 β π 6 π 2 π¬ 0 π 0
Recruitment of Mre11 to recombination sites during meiosis
The Mre11 nuclease, part of the conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs), is also essential to initiate meiotic recombination in budding yeast by promoting Spo11-induced DSBs. Recruitment of Mre11 to meiotic DSB sites depends on Rec114-Mei4 and Mer2 (RMM) that organize the meiotic DSB machinery by a mechanism involving biomolecular condensation. Here, we explored the role of Mre11 during meiosis and its relationship to RMM condensation. We show that both Mre11 and MRX complexes form DNA-dependent, hexanediol sensitive condensates in vitro. In vivo, Mre11 assembles into DNA damage-dependent foci in vegetative cells and DSB-independent foci in meiotic cells. In vitro condensates and in vivo foci both depend on the C-terminal intrinsically-disordered region (IDR) of Mre11. Importantly, while the Mre11 IDR is dispensable for vegetative DNA repair it is essential during meiosis. The C-terminus of Mre11 forms a short alpha-helix that binds a conserved region of Mer2, and mutating residues within this interface reduces Mre11 foci and DSB formation. Finally, we identified a SUMO-interacting motif within the Mre11 IDR that enhances recruitment of Mre11 during meiosis and facilitates DSB formation. This work identifies multiple mechanisms that collaborate to recruit Mre11 during meiosis to initiate recombination. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, 802525 Fonds National de la Recherche Scientifique, Bruxelles, BE, T.0031.22 Research Council VUB, SRP95, OZR3939 National Institute of Health, US, R01GM074223
Weβre happy to present a new preprint from the lab, where we identify new mechanisms that drive the recruitment of Mre11 to recombination sites during meiosis. Work led by star student Priyanka Priyadarshini with help from colleagues and funded by the ERC and FNRS.
www.biorxiv.org/content/10.1...
09.07.2025 05:56 β π 7 π 5 π¬ 1 π 0
Unequal inheritance
Against all odds the dog rose, Rosa caninae, manages to sexually reproduce with an uneven number of chromosomes. German and Czech researchers show in Nature hoe the dog rose manages this.
And still the dog rose Rosa Caninae manages to sexyally reproduce itself. German and Czech researchers show in Nature hoe the dog rose manages this.
Read more about how the dog rose manages this in my blog plantenzo.net/2025/07/08/u... 3/4
π§ͺ #PlantScience
08.07.2025 06:15 β π 2 π 1 π¬ 1 π 0
I like it that nature often finds a way against all odds. Take the dog rose, this rose bush manages to sexually reproduce even though it has an uneven number of chromosomes. 𧡠1/4
π§ͺ #PlantScience
08.07.2025 06:15 β π 10 π 8 π¬ 1 π 0
Did you see this June 2025 Nature article decoding dogrose reproduction? Hot off the press genomics advanced by EBP-affiliate Darwin Tree of Life genomes!
05.07.2025 22:31 β π 5 π 1 π¬ 0 π 0
πDouble congrats!! 1οΈβ£great science and 2οΈβ£ a really beautiful cover pictureπΉ! And actually, a third round of congratulations for that amazing cake π
04.07.2025 12:10 β π 3 π 1 π¬ 0 π 0
Thank you Stephan!
04.07.2025 04:40 β π 0 π 0 π¬ 0 π 0
π₯³ Well-deserved celebration π₯³π. What a wonderful tradition β fantastic science, brilliant cover picture @nature.com and awesome cake π° πΉ. Huge congratulations @amarques.bsky.social and team ππ
03.07.2025 14:20 β π 16 π 2 π¬ 0 π 0
(2/2) π¬ Looking for a recent success story? The June 2024 Nature article on decoding dogrose reproductionβpowered by @TreeofLife and @sangerinstitute genomesβis a stellar example of an EBP-affiliated project driving breakthroughs in plant evolution and breeding.
2025 Nature Article: bit.ly/44tjHqb
03.07.2025 15:13 β π 5 π 1 π¬ 0 π 1
(1/2) π EBP-affiliated projects worldwide are assembling genomes across the Tree of Lifeβbuilding a global reference library to accelerate research, unlock evolutionary insights, and drive biotechnological breakthroughs for the benefit of all.
@sangerinstitute.bsky.social
03.07.2025 15:07 β π 8 π 3 π¬ 1 π 0
Celebrating with our traditional paper cake! ππ°πΉ
03.07.2025 12:53 β π 33 π 2 π¬ 1 π 2
I am super happy to see our dog rose's paper featuring the cover of the July 3rd issue of @nature.com
read more here: tinyurl.com/dog-rose
02.07.2025 17:10 β π 52 π 6 π¬ 0 π 1
Congrats π
02.07.2025 10:29 β π 1 π 0 π¬ 0 π 0
Diagram of two types of reproduction based on their meiosis. A. shows typical meiosis taking place in individuals with two copies of each chromosome (diploids) resulting in both male and female gametes carrying one copy of each chromosome. Fertilization restores the double copy for each chromosome. B. shows Canina meiosis in individuals carrying five copies of each chromosome (pentaploids) where male gametes only carry one copy of each chromosome and female gametes carry four copies of each chromosome. Fertilization restores the five copy for each chromosome.
Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu.
Explained for non-experts!
01.07.2025 10:27 β π 24 π 13 π¬ 0 π 1
What an awesome surprise from @adriangonzalo.bsky.social and Joiselle! I definitely recommend reading it π
01.07.2025 15:26 β π 6 π 0 π¬ 0 π 0
Indeed π€©
23.06.2025 02:04 β π 0 π 0 π¬ 0 π 0
Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature
Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.
βͺ#Forschungsnews: Vererbung nach eigenen Regeln β Die scheinbar unmΓΆgliche Fortpflanzung der Hundsrosen πΈ
Einem Forschungsteam mit @amarques.bsky.social, Christiane Ritz und AleΕ‘ KovaΕΓk ist ein Durchbruch in der Erforschung der Fortpflanzung von Hundsrosen gelungen. π www.nature.com/articles/s41...
20.06.2025 07:42 β π 6 π 2 π¬ 0 π 0
19.06.2025 20:36 β π 0 π 0 π¬ 0 π 0
DRIVE TO SURVIVE: The seemingly impossible reproduction of dogroses hinges on a centromere trick
Max Planck Institute for Plant Breeding Research - DRIVE TO SURVIVE: The seemingly impossible reproduction of dogroses hinges on a centromere trick www.mpipz.mpg.de/pr-marques-2...
@mpipz.bsky.social @maxplanck.de
19.06.2025 13:19 β π 5 π 0 π¬ 0 π 0
Yes, that's very interesting but I am not sure these annelids are holocentric...
18.06.2025 21:28 β π 1 π 0 π¬ 0 π 0
Genome Scientist | Tree of Life Wellcome Sanger
Postdoc @ Marian University | polyploidy | science outreach & mentorship | #proudappalachian #firstgen
Associate Professor of Biological Sciences. We study genomes (WGD, etc.), and the ecology and evolution of fishes.
π±πͺ΄πΏπ¬π³οΈβπ
Lover of plants and microscopy.
Assistant Professor, Department of Plant and Microbial Biology, Univerisity of Minnesota.
Lab: radinlab.org/
Instagram: radinbio
π¬ Evolutionary genetics/genomics, repeated adaptation, πΈ pigmentation, ποΈ alpine environment, polyploidy
MSCA fellow at Charles Uni π¨πΏ and Uni Bernπ¨π
X @MajdaHolcova
Plant Meiosis Researcher. Group Leader and Royal Society University Research Fellow. John Innes Centre, UK
Chromosome focused | Couldn't live without: coffee buddies, music, challenges
Scientific Curator of Seed Conservation @ntbgarden.bsky.social, Affiliate Graduate Faculty in Botany @ U Hawaii, Deputy Chair @IUCN Seed Conservation Specialist Group. Ph.D. from @nhmdk.bsky.social. #Iamabotanist
Assistant Prof. @Utrecht University (NL). I study epigenetic regulation of cell fates using single-cell genomics and data science. Previously at Max Planck-IE (DE) and Hubrecht Institute (NL). https://vblab.org
Biologist, interested in the evolution of networks and genomes. Senior Lecturer in Microbiology at Nottingham Trent University. she/her
Incoming Assistant Professor, NJIT Biological Sciences (Fall '26) | Current postdoc, University of Lausanne, Benton Group | GSU & UF alumnus | sensory biology, genetics, behavior, and evolution (especially in the Twilight Zone)
https://himmellab.org
Studying stem cells/i-cells, regeneration, cellular plasticity, & differentiation in the colonial cnidarian Hydractinia at the Whitney Laboratory, University of Florida. Cnidofest meeting organizer.
Lab Website: https://tinyurl.com/39u637tt
Studying behavioral evolution, from mosquitoes to mole-rats | Leon Levy Scholar at Columbia Zuckerman Institute working w/ Ishmail Abdus-Saboor | PhD Princeton (w/ Lindy McBride), MA Columbia (w/ Dustin Rubenstein) | ιΊ»εΈ/ζ±ε€§ alum π―π΅ | yukihaba.github.io
Interested in the spatially organized interaction of physical and biochemical root barriers and the root microbiome π±π¦ π§¬π¬
Biophysicist & computational biologist | Genome organization, chromatin modeling
Postdoc at Institut Curie, Paris (Leonid Mirny group) | Formerly at IMBA, Vienna (Anton Goloborodko group)
Scientific illustrator and wildlife artist.
Former scientist - biologist
Commissions: lazaroillustration@gmail.com
Prints store: https://www.inprnt.com/gallery/javi_lazaro/
Web: https://www.lazaroillustration.com/
Human artist. No AI art.
We are a biodiversity genomics community to generate reference quality genomes for all European species. #Genomes for #Biodiversity
https://www.erga-biodiversity.eu/ | https://linktr.ee/erga_biodiversity
Scientist | Collaborative Leadership Consultant for STEM Leaders and Organizations at BridgUs Lab
the unculturables: exploratory research & beyond. EMBO-YIP 2003, EAM 2012, adERC 2013, EMBO 2024. https://beja.net.technion.ac.il/
