AndrΓ© Marques's Avatar

AndrΓ© Marques

@amarques.bsky.social

A lover of chromosome biology πŸ§¬πŸ”¬πŸ”Ž Studying (not only) meiosis, centromeres & genome evolution in plants! Group leader at MPI for Plant Breeding Research in Cologne, Germany Lab website: https://www.mpipz.mpg.de/5028512/marques

2,244 Followers  |  1,086 Following  |  122 Posts  |  Joined: 05.12.2023  |  2.0725

Latest posts by amarques.bsky.social on Bluesky

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For decades, scientists puzzled over a genetic anomaly. They just solved it. By examining β€œjunk DNA,” scientists are finding clues to understanding human biology.

For decades, scientists puzzled over a genetic anomaly. They just solved it. wapo.st/3VyLmlx

24.09.2025 19:42 β€” πŸ‘ 21    πŸ” 7    πŸ’¬ 0    πŸ“Œ 2

Done!

13.09.2025 07:00 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

go.bsky.app/KqsM3kd

13.09.2025 07:00 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

My department at Dartmouth Medical School is hiring a tenure-track Assistant Professor. We are looking broadly for a biochemist or cell biologist. Please share this add! apply.interfolio.com/171438
@dartmouthbcb.bsky.social @futurepislack.bsky.social

27.08.2025 20:50 β€” πŸ‘ 53    πŸ” 56    πŸ’¬ 1    πŸ“Œ 4
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Head of Service Unit Proteomics

Attention plant proteomics specialists: We are looking for a Head of our new Proteomics Unit at our international and dynamic Max Planck Institute of Molecular Plant Physiology. @mpi-mp-potsdam.bsky.social Applications are welcome until 30. Sept 2025: jobs.mpimp-golm.mpg.de/jobposting/8...

23.08.2025 08:27 β€” πŸ‘ 36    πŸ” 54    πŸ’¬ 0    πŸ“Œ 0
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πŸŒΏπŸš— Between 29 Jul–12 Aug we covered more than 2,000 km across Northeast Brazil on an unforgettable plant collection trip. Huge thanks to my PhD student Ruiyi and collaborators Profs. AndrΓ© Vanzela & Leonardo P. Felixβ€”great teamwork, inspiring science, and breathtaking biodiversity! 🌱
#plantscience

21.08.2025 13:44 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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Our paper showing that variation in transcription factor binding sites underlies the majority of additive genetic variance for phenotypic variation in maize is finally out!

Sadly they didn't use our suggested cover image below (made by the inimitable Andi Kur).

www.nature.com/articles/s41...

11.08.2025 14:29 β€” πŸ‘ 253    πŸ” 75    πŸ’¬ 6    πŸ“Œ 5

Centromeres, polyploidy, carnivorous plant, instant bookmark.

28.07.2025 12:37 β€” πŸ‘ 10    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Contrasting centromere structures in carnivorous sundews uncover a dynamic evolutionary trajectory shaped by polyploidy and chromosomal remodeling Sundews (Drosera) are carnivorous plants that capture prey using mucilage-producing glands with both secretory and absorptive functions. Within a remarkably diverse clade that includes the Venus flytr...

Happy to share our new work with exciting findings, incl. different centromere organisations and all kinds of weird polyploids giving rise to the mysterious carnivorous sundews! Great word led by my postdoc Laura in collaboration with @plantgenomes.bsky.social
www.biorxiv.org/content/10.1...

28.07.2025 12:27 β€” πŸ‘ 17    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis

www.nature.com/articles/s41...

08.07.2025 16:11 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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#ERGAReads | Analysis of 3 pentaploid dogrose genomes provide insights into their unique reproductive strategies & advance our understanding of genome #evolution and meiotic mechanisms in organisms with asymmetrical inheritance systems 🏡️
πŸ”— www.nature.com/articles/s41...
@sgn.one @ceplas.bsky.social

09.07.2025 08:56 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Recruitment of Mre11 to recombination sites during meiosis The Mre11 nuclease, part of the conserved MRX complex involved in the repair of DNA double-strand breaks (DSBs), is also essential to initiate meiotic recombination in budding yeast by promoting Spo11-induced DSBs. Recruitment of Mre11 to meiotic DSB sites depends on Rec114-Mei4 and Mer2 (RMM) that organize the meiotic DSB machinery by a mechanism involving biomolecular condensation. Here, we explored the role of Mre11 during meiosis and its relationship to RMM condensation. We show that both Mre11 and MRX complexes form DNA-dependent, hexanediol sensitive condensates in vitro. In vivo, Mre11 assembles into DNA damage-dependent foci in vegetative cells and DSB-independent foci in meiotic cells. In vitro condensates and in vivo foci both depend on the C-terminal intrinsically-disordered region (IDR) of Mre11. Importantly, while the Mre11 IDR is dispensable for vegetative DNA repair it is essential during meiosis. The C-terminus of Mre11 forms a short alpha-helix that binds a conserved region of Mer2, and mutating residues within this interface reduces Mre11 foci and DSB formation. Finally, we identified a SUMO-interacting motif within the Mre11 IDR that enhances recruitment of Mre11 during meiosis and facilitates DSB formation. This work identifies multiple mechanisms that collaborate to recruit Mre11 during meiosis to initiate recombination. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, 802525 Fonds National de la Recherche Scientifique, Bruxelles, BE, T.0031.22 Research Council VUB, SRP95, OZR3939 National Institute of Health, US, R01GM074223

We’re happy to present a new preprint from the lab, where we identify new mechanisms that drive the recruitment of Mre11 to recombination sites during meiosis. Work led by star student Priyanka Priyadarshini with help from colleagues and funded by the ERC and FNRS.

www.biorxiv.org/content/10.1...

09.07.2025 05:56 β€” πŸ‘ 7    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis www.nature.com/articles/s41...

08.07.2025 07:08 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Unequal inheritance Against all odds the dog rose, Rosa caninae, manages to sexually reproduce with an uneven number of chromosomes. German and Czech researchers show in Nature hoe the dog rose manages this.

And still the dog rose Rosa Caninae manages to sexyally reproduce itself. German and Czech researchers show in Nature hoe the dog rose manages this.
Read more about how the dog rose manages this in my blog plantenzo.net/2025/07/08/u... 3/4

πŸ§ͺ #PlantScience

08.07.2025 06:15 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

Interesting paper on the reproduction of odd ploidy plants. www.nature.com/articles/s41...

08.07.2025 06:37 β€” πŸ‘ 10    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
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Unequal inheritance Against all odds the dog rose, Rosa caninae, manages to sexually reproduce with an uneven number of chromosomes. German and Czech researchers show in Nature hoe the dog rose manages this.

Very nice summary from @plantenzo.bsky.social about our recent paper on pentaploid dog roses

Unequal inheritance plantenzo.net/2025/07/08/u...

08.07.2025 12:39 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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I like it that nature often finds a way against all odds. Take the dog rose, this rose bush manages to sexually reproduce even though it has an uneven number of chromosomes. 🧡 1/4

πŸ§ͺ #PlantScience

08.07.2025 06:15 β€” πŸ‘ 10    πŸ” 8    πŸ’¬ 1    πŸ“Œ 0

Did you see this June 2025 Nature article decoding dogrose reproduction? Hot off the press genomics advanced by EBP-affiliate Darwin Tree of Life genomes!

05.07.2025 22:31 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

🎊Double congrats!! 1️⃣great science and 2️⃣ a really beautiful cover picture🌹! And actually, a third round of congratulations for that amazing cake πŸ˜‹

04.07.2025 12:10 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Thank you Stephan!

04.07.2025 04:40 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

πŸ₯³ Well-deserved celebration πŸ₯³πŸŽ‰. What a wonderful tradition – fantastic science, brilliant cover picture @nature.com and awesome cake 🍰 🌹. Huge congratulations @amarques.bsky.social and team πŸ‘πŸ‘

03.07.2025 14:20 β€” πŸ‘ 17    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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(2/2) πŸ”¬ Looking for a recent success story? The June 2024 Nature article on decoding dogrose reproductionβ€”powered by @TreeofLife and @sangerinstitute genomesβ€”is a stellar example of an EBP-affiliated project driving breakthroughs in plant evolution and breeding.
2025 Nature Article: bit.ly/44tjHqb

03.07.2025 15:13 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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(1/2) 🌍 EBP-affiliated projects worldwide are assembling genomes across the Tree of Lifeβ€”building a global reference library to accelerate research, unlock evolutionary insights, and drive biotechnological breakthroughs for the benefit of all.
@sangerinstitute.bsky.social

03.07.2025 15:07 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

Celebrating with our traditional paper cake! πŸ“„πŸ°πŸŒΉ

03.07.2025 12:53 β€” πŸ‘ 33    πŸ” 2    πŸ’¬ 1    πŸ“Œ 2
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I am super happy to see our dog rose's paper featuring the cover of the July 3rd issue of @nature.com

read more here: tinyurl.com/dog-rose

02.07.2025 17:10 β€” πŸ‘ 52    πŸ” 6    πŸ’¬ 0    πŸ“Œ 1

Congrats πŸŽ‰

02.07.2025 10:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Diagram of two types of reproduction based on their meiosis. A. shows typical meiosis taking place in individuals with two copies of each chromosome (diploids) resulting in both male and female gametes carrying one copy of each chromosome. Fertilization restores the double copy for each chromosome. B. shows Canina meiosis in individuals carrying five copies of each chromosome (pentaploids) where male gametes only carry one copy of each chromosome and female gametes carry four copies of each chromosome. Fertilization restores the five copy for each chromosome.

Diagram of two types of reproduction based on their meiosis. A. shows typical meiosis taking place in individuals with two copies of each chromosome (diploids) resulting in both male and female gametes carrying one copy of each chromosome. Fertilization restores the double copy for each chromosome. B. shows Canina meiosis in individuals carrying five copies of each chromosome (pentaploids) where male gametes only carry one copy of each chromosome and female gametes carry four copies of each chromosome. Fertilization restores the five copy for each chromosome.

Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu.

Explained for non-experts!

01.07.2025 10:27 β€” πŸ‘ 24    πŸ” 13    πŸ’¬ 0    πŸ“Œ 1

What an awesome surprise from @adriangonzalo.bsky.social and Joiselle! I definitely recommend reading it πŸ˜…

01.07.2025 15:26 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Indeed 🀩

23.06.2025 02:04 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis - Nature Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

β€ͺ#Forschungsnews: Vererbung nach eigenen Regeln – Die scheinbar unmΓΆgliche Fortpflanzung der Hundsrosen 🌸
Einem Forschungsteam mit @amarques.bsky.social, Christiane Ritz und AleΕ‘ KovaΕ™Γ­k ist ein Durchbruch in der Erforschung der Fortpflanzung von Hundsrosen gelungen. πŸ‘‰ www.nature.com/articles/s41...

20.06.2025 07:42 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

@amarques is following 20 prominent accounts