Gavin Williams

Excited to share our #polyketide #biosensor artwork featured on the cover of Biochemistry! Thanks to several group members for your help with this! #MyACSCover

Engineering the Specificity of Acetyl-CoA Synthetase for Diverse Acyl-CoA Thioester Generation CoA thioesters are valuable intermediates in numerous biosynthetic routes and metabolic processes. However, diversifying these compounds and their corresponding downstream products hinges on broadenin...

pubs.acs.org/doi/full/10....

Thrilled to share our latest enzyme engineering in ACS Chemical Biology! We improved an enzyme involved in #polyketide starter unit biosynthesis and used it to generate polyketide acceptor substrates in vitro. Kudos to Jared and the team of authors! @pubs.acs.org

Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative The prenyl motif determines the biological activity of many natural products. Yet, structural diversification of the prenyl site has been restricted due to the limitations of native biosynthetic pathw...

pubs.acs.org/doi/10.1021/...

Excited to share our @pubs.acs.org Syn Bio publication on the production of non-natural alkylated Trp derivatives in E. coli. Potential applications for #terpene diversification. Kudos to everyone who contributed to this work.

Directed Evolution of a Macrolide-Sensing Transcription Factor Biosensor for the Detection of Macrolactone Aglycones via “Effector Walking” and Efflux Pump Deletion Glycosylated macrolactones (macrolides) often display broad and potent biological activities and are targets for drug development and discovery. The modular genetic organization of macrolide polyketid...

I am thrilled to share our latest biosensor publication in ACS Biochemistry. In this work, we engineered a #biosensor strain for detecting polyketide macrolactones as a step toward applying high-throughput #synbio to polyketide synthases. pubs.acs.org/doi/10.1021/... @ncstatechem.bsky.social