Chris Byrne

Word of the day is ‘forwallowed’ (15th century): extremely weary from tossing and turning all night.

🤣🤣 Off her head

The figure shows the percentage of patients with fibrosis stage 2 or 3 who had resolution of steatohepatitis with no worsening of liver fibrosis (Panel A) and reduction in liver fibrosis with no worsening of steatohepatitis (Panel B) after 72 weeks, with the estimated difference expressed in percentage points.

In this interim analysis of a phase 3 trial involving 800 patients with metabolic dysfunction–associated steatohepatitis, once-weekly semaglutide improved liver histologic results at 72 weeks. Full ESSENCE trial results: nej.md/3EVFAFM

#MedSky #EndoSky #GastroSky

Public-health experts should be more political, not less Health has always been political, long before Donald Trump and Robert F. Kennedy Jr took power. Denying this is what’s been killing us.

“The real crisis is not that public health — which is fundamentally about policies dictating the distribution of resources required to protect human life — has been politicized. It is that it has not been politicized nearly enough,” writes Eric Reinhart in Nature. 🧪

The general trend is crazy. Here is Twitter vs Bluesky volumes for the last week. On some days they are equal in volume.

Every year, there are an estimated 833 760 (95% UI 493 716–1 544 395) new HCV infections attributable to injecting drug use globally

The global decline needed to meet the 2030 WHO target is 76·7% (95% UI 71·8–81·3)

#HepSky #IDSky #MedSky #LiverSky

Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment Nature Reviews Gastroenterology & Hepatology, Published online: 17 February 2025; doi:10.1038/s41575-025-01045-zThis Review discusses the link between metabolic dysfunction-associated steatotic liver disease (MASLD) — a heterogeneous health condition —…

New online! Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment

100%.

Publishers’ profits are colossal and these APC figures speak to that.

When care causes harm: a systematic review of adverse experiences in mental health wards - National Elf Service New review takes a broad approach to understanding and categorising adverse inpatient experiences, informing how best to respond to prevent harms.

When care causes harm: a systematic review of adverse experiences in mental health wards www.nationalelfservice.net?p=210756

#MentalHealthCare #InpatientCare #Harm #PatientExperiences #Qualitative #Seclusion #Restraint #Coercion #Safety #Dignity #Respect #MentalHealthServiceDesign

The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh - Harm Reduction Journal Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. ...

🚨 New paper: ‘The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh’

harmreductionjournal.biomedcentral.com/articles/10....

My very last issue (on ♿️) has now come out with BMJ Medical Humanities: I have stepped down from my role as Editor in Chief. There are a lot of factors—after 17 years editing two consecutive journals, it was time. But there’s more, and I feel we should talk about the climate of #academic publishing

Trend chart showing rate of alcohol deaths in England per 100,000 between 2006 and 2023. Shows rise from 10.8 per 100,000 in 2019 to 15.0 per 100,000 in 2023. A rise of 39% (and an absolute increase in numbers of 42%). Data from https://fingertips.phe.org.uk/profile/local-alcohol-profiles/data#page/4/gid/1938132984/pat/159/par/K02000001/ati/15/are/E92000001/iid/91380/age/1/sex/4/cat/-1/ctp/-1/yrr/1/cid/4/tbm/1

Today's OHID data shows the number of deaths caused by alcohol in England have now risen for *five years in a row* and are 40% higher than pre-pandemic.

England hasn't had an alcohol strategy for over a decade.

The case for action has never been stronger 👇
www.telegraph.co.uk/global-healt...

Report published in @AddictionJrnl here: onlinelibrary.wiley.com/doi/10.1111/...

If you hate statistics like I do, then you'll love my free lectures. Putting science before statistics, 20 lectures from basics of inference & causal modeling to multilevel models & dynamic state space models. It's all free, made with love and sympathy. 🧪 #stats www.youtube.com/playlist?lis...

This is why funders should pay for project managers. For my recent multinational, 5-year project across 4 countries, NIH cut our only 0.5 administrator - so now all admin needs to be done by the researchers. Crazy.

Leveraging Old Hepatitis C Therapies | NEJM Older drugs could potentially advance U.S. hepatitis C elimination efforts. The government could act like a business and use all current and historical market information to its advantage.

Leveraging old hepatitis C therapies

via @nejm.org

www.nejm.org/doi/full/10....

#LiverSky #HepSky #IDSky

NEW: Is the NHS still good value for money?

Billions of pounds are being ploughed into Britain’s health service — with little noticeable improvement in health since 2019.

Critics say the NHS has become bloated and inefficient. Is it?

@thetimes.com

🔗 www.thetimes.com/article/1130...

1/7

LJMU Drug Related Deaths conference 2025 slide image

We're pleased to announce that our LJMU Drug Related Deaths Conference 2025 will take place online on Friday 28th March. Previous events have seen some great discussions and networking so we expect a really worthwhile event. Registration is now open here: ims.ljmu.ac.uk/DRDconference #DRDevent

🚨 New review in @natrevgastrohep.bsky.social:
Should you take probiotics with antibiotics?
www.nature.com/articles/s41...

Bottom line: current evidence does not support the common perception that probiotics can facilitate the gut microbiome's recovery from antibiotics. BUT! 1/🧵