Rajat Kumar Jha

Congrats to the newly-minted Ph.D. from the @smithlabumbc.bsky.social Dr. Misti Cartwright @chemisti.bsky.social ! Way to go on an excellent thesis defense!!

19.08.2025 18:07 — 👍 4    🔁 2    💬 1    📌 0

Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi Nuclei define eukaryotes, enabling macromolecular compartmentalization and cellular regulation. Each nucleus is believed to contain one or more haploid sets of chromosomes (1N). However, we discovered...

Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi | Science www.science.org/doi/10.1126/...

23.05.2025 04:07 — 👍 0    🔁 0    💬 0    📌 0

Evolved gene editor inserts entire genes in human cells The new system is the first to use a DNA-mobilizing enzyme called a CRISPR-associated transposase to make targeted gene-sized edits at therapeutically useful levels in human cells.

Using laboratory-evolved versions of enzymes called CASTs, researchers have achieved a long-standing goal of genome editing: inserting entire healthy genes into human cells efficiently enough for potential therapeutic applications. @isaacwitte.bsky.social @eitzingersimon.bsky.social

15.05.2025 19:04 — 👍 14    🔁 6    💬 1    📌 0

Structure and mechanism of aminoacyl-tRNA-protein L/F- and R-transferases The aminoacyl-tRNA-protein transferases (also known as aa-transferases) are a class of enzymes that utilize a highly conserved GCN5-related N-acetyltr…

Here's one to add to your Friday reading list! 🚨Just in press in J. Mol. Biol.🚨: a beautiful review on the structures, mechanisms, regulation, and open questions of aminoacyl-tRNA-protein transferases by Misti and Rajat who work on amino acid transferases! Read the paper here:

tinyurl.com/mr386wsn

16.05.2025 12:44 — 👍 6    🔁 2    💬 0    📌 0

Measurements of molecular size and shape on a chip Size and shape are critical discriminators between molecular species and states. We describe a microchip-based high-throughput imaging approach offering rapid and precise determination of molecular pr...

An amazing new enabling technology. Measurements of molecular size and shape on a chip. Couldn't be prouder of our friend Madhavi Krishnan of @ox.ac.uk this was and is one among the must fun collaborations I ever had. www.science.org/doi/10.1126/...

09.05.2025 08:00 — 👍 70    🔁 35    💬 8    📌 6

The Cia1 and Cia2 subunits of the CTC mediate recognition of apo-FeS proteins with a C-terminal targeting complex recognition motif The cytosolic iron-sulfur cluster assembly (CIA) targeting complex is responsible for maturation of cytosolic and nuclear iron-sulfur enzymes, numbering >30 proteins critical for fundamental processes...

So excited to get this work out there! We have been working hard to "crack the CIA code" - more to come soon!
www.biorxiv.org/content/10.1...

27.03.2025 11:49 — 👍 5    🔁 2    💬 0    📌 0

In-cell architecture of the mitochondrial respiratory chain Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...

Wow. This is really stunning . www.science.org/doi/10.1126/...

21.03.2025 18:02 — 👍 55    🔁 8    💬 1    📌 2

NIH announces some key grant-review meetings will restart in late March Trump policy blocking required notices has frozen reviews of thousands of grants

At least some meetings essential to approving new grants by the National Institutes of Health will be back on track later this month. scim.ag/41FbfEg

03.03.2025 19:33 — 👍 91    🔁 22    💬 1    📌 1

AlphaFold has achieved significant success in protein prediction, even winning a Nobel Prize. AlphaFold3 now includes predictions for different molecules. What are the current limitations in predicting RNA structure? #3DRNAStructure #AlphaFold3 doi.org/10.1107/S205...

04.03.2025 15:28 — 👍 11    🔁 4    💬 0    📌 0