Drew Kiraly, MD, PhD

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

ReThink - The Gene Lay Institute

‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/

New publication from our CFAR members!
PET imaging with [11C]MPC-6827 reveals disrupted microtubule integrity in a nonhuman primate model of alcohol use disorder.
Check out the full study: doi.org/10.1016/j.dr...

Headshot of Dr. Jibran Khokhar

We are delighted to welcome Dr. Jibran Khokhar @drjkhokhar.bsky.social to our Editorial Board!!

Dr. Khokhar's research focuses on the mechanisms underlying co-occurring mental illness & substance use disorders, and assessing how long-term adolescent cannabis use might contribute to disease risk.

Does anyone on here have experience with ELK Biotech products? I want to measure something by ELISA and theirs is significantly cheaper than the few others available, but want to make sure it is quality enough.

Window birb

100% Seemed to happen when all the companies started pushing that they were using AI to make it "better" and "smarter"

The thing about scientific research is that it’s one of the few national investments that’s a clear public good even if you entirely discount the actual ostensible point of it.

benion Grieving a wasted life At a point in life when there are far too many days behind than ahead, one tends to re-elected in contrast to standing up for the reflect on a life lived. In my lifetime decades greater good? were devoted to protecting America. Sacri A compromised Supreme Court recently fices were made both by myself and my fam- trotted out a shallow token standards of Ily in military service. The tip of the spear: conduct for themselves. Apparently it's Countless weeks over the years were spent not a bribe to accept favors after a deci-sion; only before. Corporations are people? living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since. way?" The purpose: if required, be airborne Pay-to-play is the theme of the day. Un- in minutes on a one-way trip bringing a challenged and uncontested blatant conflicts nuclear Armageddon to an adversary. Fly: of interest abound. The rule of law is situ- ing the unfriendly skies over North Viet- ational if adhered to at all. America can no nam provided a brief interlude, but overall, longer be trusted. The unbridled pursuit of this long line of silent sentinels stood firm power and wealth driven by unquenchable to protect America by deterring external greed has left service above self and Con- threats to our freedoms and way of life stitutional norms in the dustbin of a quaint across the decades. I was privileged to serve past. with men and women of integrity imbued Recently the VA said exposure to Agent with a sense of service. Orange is the probable cause of the can- I'm truly grateful that the B-52s we flew, which were built tough, were engineered cers I live with. Actually I suspect it's more from yet unspecified sources, which cause on scientific principles and fabricated by experienced, skilled workers rather than military pilots to have significantly higher founded on mere beli…

This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.

Our next CFAR 2024 Research Round-Up post features work from the Kiraly Lab examining clinical and preclinical evidence for gut microbiome mechanisms in substance use disorders.

Our next CFAR 2024 Research Round-Up post features work from the Egan Lab examining perceptions of disposal options for unused opioid analgesics among individuals prescribed opioids in North Carolina.

Our next CFAR 2024 Research Round-Up post features work from the Rhodes Lab examining youth and young adult knowledge of and access to opioid harm reduction policies and interventions in North Carolina.

Our next CFAR 2024 Research Round-Up post features work from the Hurley Lab on the NIH Pain Common Data Elements, highlighting progress, challenges, and future directions for improving pain assessment and data integration.

Our next CFAR 2024 Research Round-Up post features work from the Nader Lab on behavioral and extracellular vesicle biomarkers linked to nicotine’s enhancement of cocaine reinforcement in male and female monkeys, highlighting sex-specific mechanisms in polysubstance use.

Our first CFAR 2024 Research Round-Up post features work from the Nader Lab showing that the D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys, offering insight into potential treatments for stimulant addiction.

A great thread highlighting recent work from our Center for Addiction Research. Would encourage anyone interested to follow along.

Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice - Nature Communications Here, the authors show that different formulations of medical ketogenic diets, and dietary fiber content in particular, differentially impact seizure outcome in mice, via modifying the gut microbiome ...

Very happy to share new findings by Ezgi Özcan and colleagues showing that differences in fiber content in medical ketogenic diets can influence their anti-seizure effects! www.nature.com/articles/s41...

Shumanji!

Screenshot of article entitled "Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy" by Yu Feng, Keziah S. Diego, Zhe Dong, ..., Nadia N. Khan, Denise J. Cai, and Tristan Shuman. In brief: Feng et al. demonstrate that memory deficits in temporal lobe epilepsy involve multiple discrete mechanisms with distinct time courses. In epileptic mice, early-onset memory deficits are associated with disrupted hippocampal synchronization, while more severe, lateonset impairments are associated with disrupted synchrony of medial entorhinal cortex circuits.

New paper out in Cell Reports! Led by @susieyufeng.bsky.social, we found that chronic epilepsy in mice drives distinct synchronization deficits in hippocampus and MEC, with early changes in HPC and late-onset changes in MEC that align with progressive memory impairment.
www.cell.com/cell-reports...

a short think piece on one of the most mysterious substances in the brain - and one of my favorite topics @thetransmitter.bsky.social

First ever post on here to show off an exciting manuscript from the lab that has been a long time coming. Interactions of the microbiome and response to opioids in adolescent and adult mice: www.biorxiv.org/content/10.1...