Ksenia Stankevich

London Biotechnology Show The London Biotechnology Show aims to accentuate the progress of biotechnology in the United Kingdom and around the world by bringing together leading industry experts and key stakeholders from the en...

Attending londonbiotechshow.com today in London! I’d love to connect and discuss our novel deuteration technology - let’s talk science, strategy, and potential collaborations with @spicerlab.bsky.social
See you there!

19.06.2025 05:37 — 👍 0    🔁 0    💬 0    📌 0

Today & tomorrow I will be at #chemuk to connect with companies and researchers interested in user-friendly deuteration platform we developed at @spicerlab.bsky.social If you're attending and curious about the potential for collaboration - I’d love to meet!

21.05.2025 11:54 — 👍 0    🔁 1    💬 0    📌 0

www.organic-chemistry.org/abstracts/li...
The use of a Claisen-Sakurai reaction in a one-pot sequence provides highly substituted cyclopentenols in high stereoselectivity.

17.04.2025 10:19 — 👍 1    🔁 1    💬 0    📌 0

Effect of Pyridinecarboxaldehyde Functionalization on Reactivity and N-Terminal Protein Modification The site-selective modification of protein N-termini represents a powerful strategy for producing homogeneous bioconjugates. 2-Pyridinecarboxaldehydes have emerged as a leading reagent class in this area. However, these conjugations suffer from relatively slow rates and a degree of reversibility. In this work, we therefore studied the effects of pyridinecarboxaldehyde functionalization on N-terminal modification. This allowed us to provide insight into the factors governing relative contributions from competing reaction pathways and design criteria for second generation reagents for protein labeling. Importantly, 3-methoxy-2-pyridinecarboxaldehydes were identified as providing both accelerated and more stable protein labeling, enabling further applications of this powerful technology.

Our latest paper from Lydia and @kstankevich.bsky.social
is out in JACS Au! We wanted better reagents for selectively labelling protein N-termini, so looked at how functionalisation affected each step of the complex equilibrium, leading to faster and more stable probes.
pubs.acs.org/doi/10.1021/...

09.04.2025 11:39 — 👍 2    🔁 2    💬 0    📌 0