Agnieszka Konopacka

Structural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome - Nature Communications K11/K48 branched ubiquitin chains regulate protein degradation and cell cycle progression. Here, the authors report the structural basis of how such a branched ubiquitin chain is recognized by the hum...

If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications:
doi.org/10.1038/s414...

Highly recommended!

🌟 Speaker Spotlight: Target ID and Validation in Drug Discovery – Oct 24th 2025 🌟 | Society for Medicines Research 🌟 Speaker Spotlight: Target ID and Validation in Drug Discovery – Oct 24th 2025 🌟 We are excited to welcome Dr David Hulcoop, the Executive Director at Open Targets European Bioinformatics Institute...

www.linkedin.com/posts/societ...

Highly recommended!

🎉 2025 DFCI TPD event registration is open!
📆 Sep 11, 11:30 AM–8 PM ET, Boston
🔑 Keynote: Nathanael Gray
📝 Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI

Expanding the reach of molecular glue degraders An epitope-centric screening approach widens the neosubstrate landscape for targeted protein degradation

getting less sticky…

www.science.org/doi/10.1126/...

SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

The legendary EMBO Integrative Modeling Course is back! If you want to be in this picture in the 2025 edition, just go ahead and register at meetings.embo.org/event/25-bio...

Organized by myself & @amjjbonvin.bsky.social & @arneelof.bsky.social & @lindorfflarsen.bsky.social

Five people at a restaurant table, looking in to the camera and smiling.

Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!

YouTube video by ukjoncollins ICR - The Unfinished Symphony

Unfinished Symphony
@icr.ac.uk @temt-icr.bsky.social

youtu.be/yjelh9iQWMA?...

Target Engagement Assays in Early Drug Discovery In target-based drug discovery, quantification of target engagement is required to build structure–activity relationships and develop a potent clinical candidate. Target engagement data also provides evidence of a drug’s mechanism of action (MoA) which although is not required for approval, can increase the chance of a successful clinical outcome. Consequently, a plethora of assays has been developed to provide information about target engagement on isolated proteins and in cells. These techniques monitor changes in stability, structure, optical properties or mass difference between proteins and their complexes with ligands. They also provide characterization of the compound with thermodynamic, kinetic and structural binding parameters. The diversity of approaches reflects the challenges faced when drugging different protein classes, with each method having advantages, trade-offs and target specificity.

A timely and useful JMC Perspective: St John-Campbell & Bhalay (2025) Target Engagement Assays in Early #DrugDiscovery | #OpenAccess #MedChem #ChemBiol #DrugDesign #cheminformatics #chemsky 🧪
doi.org/10.1021/acs....

#womenshealth #drugdiscovery #biotech #pharma #smr2025 #endometriosis… | Society for Medicines Research 🔬Join Us for the 1st SMR Women’s Health Meeting 📣 📣 📣   The SMR is delighted to launch its first Women’s Health meeting - a focused, one-day scientific event aimed at accelerating therapeutic discove...

www.linkedin.com/posts/societ...

Cellular parameters shaping pathways of targeted protein degradation - Communications Biology This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs.

New review from authors Annabel Cardno, Bryony Kennedy, and Catherine Lindon from University of Cambridge comes a review of the important aspects to consider for obtaining optimal degrader activity. From localization to activity of ligase to target accessibility!
www.nature.com/articles/s42...

The SMR @socmedres.bsky.social is a non-profit UK organisation that brings together great pharma industry, biotech, academia and funders communities to foster excellence in drug discovery. Highly recommended.

The SMR @socmedres.bsky.social brings together great research communities from academia and industry. Highly recommended! 🌟

A method for the detection and enrichment of endogenous cereblon substrates C-Terminal cyclic imides are posttranslational modifications on proteins that are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN). Despite the observation of these modificati...

New preprint out co-led by Hannah Lloyd and Christina Woo at Harvard along with colleagues at the Broad and CeTPD Dundee gives insight on how to detect and discover native substrates of CRBN!
www.biorxiv.org/content/10.1...

Global analysis of protein turnover dynamics in single cells The SC-pSILAC method enables single-cell measurement of both protein abundance and turnover, providing notable advances in the depth and versatility of proteomic technologies.

🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!

www.cell.com/cell/fulltex...

Congratulations to The Institute of Cancer Research for winning the Award… | Tatiana McHardy Congratulations to The Institute of Cancer Research for winning the Award on the category for Best Performing Non-Profit Research Organisation of the Year on…

Kudos to all colleagues at the Institute of Caner Research! Proud to be part of the team! @icr.ac.uk

ICR Centre for Protein Degradation on LinkedIn: Higher Scientific Officer - Drug Discovery Biology, Centre for Protein… 🤝 Are you passionate about Targeted Protein Degradation and want to join us on our mission to make the discoveries that defeat cancer? Dr Agnieszka…

🌟🌟🌟 Join our cancer drug discovery team in London-Sutton! 🌟🌟🌟
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR

Great opportunity for experienced cancer biology drug discovery leaders 📣📣📣

📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀

🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities

📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...

December 2022, at the Humanitarian Hub at London Stansted Airport supporting refugees fleeing the war in Ukraine 💛💙🇪🇺🇪🇺🇪🇺🇪🇺

ICR Centre for Protein Degradation on LinkedIn: Higher Scientific Officer - Drug Discovery Biology, Centre for Protein… 🤝 Are you passionate about Targeted Protein Degradation and want to join us on our mission to make the discoveries that defeat cancer? Dr Agnieszka…

🌟🌟🌟 Join our cancer drug discovery team in London-Sutton! 🌟🌟🌟
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR

‘It would be seen as political’: why the Royal Society is torn over Elon Musk Many fellows feel the billionaire has breached its code of conduct, but others say scientific neutrality is at stake

It would be *spun* as political, but the challenge to the RS is whether it has the courage to stand by the values of science its code of conduct requires of all Fellows. Without that, how can it maintain its claim to speak for the wider scientific community? www.theguardian.com/science/2025...

🌟Speaker Spotlight: 2nd SMR Molecular Glues Meeting🌟

We are excited to welcome Dr Katherine Donovan @katherinedonovan.bsky.social from @danafarber.bsky.social as one of our distinguished speakers!

📅 21st March 2025
📍 GSK Stevenage, UK
🔗 lnkd.in/dNwWVtwE

Join us at this exceptional event!

🌟 Speaker Spotlight: 2nd SMR Molecular Glues Meeting🌟

We are excited to welcome Dr Ingo Kober from Merck KGaA in Darmstadt, Germany as one of our distinguished speakers!

📅 21st March 2025
📍 GSK Stevenage, UK
🔗 lnkd.in/dNwWVtwE

Don't miss out - register now and be part of this exceptional event!

🌟 Speaker Spotlight: 2nd SMR Molecular Glues Meeting🌟

We are excited to welcome Dr Aneika Leney from University of Birmingham, UK as one of our distinguished speakers!

📅 21st March 2025
📍 GSK Stevenage, UK
🔗 Registration: lnkd.in/dNwWVtwE

Two weeks to go! The 2nd SMR Molecular Glues Meeting 🚀🚀🚀
🌟 World-class speakers
🌟 Cutting-edge insights
🌟 Networking opportunities

📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...

The Continuing Crisis, Part VII: An Overview

Another “Continuing Crisis” post, this one covering some larger principles and explaining why I’m doing these in general: