If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications:
doi.org/10.1038/s414...
@agako7.bsky.social
Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation, Institute of Cancer Research, London
If you're curious about how cells quickly eliminate misfolded proteins produced under proteotoxic stress or mitotic substrate during cell cycle progression, check out our latest article in Nature Communications:
doi.org/10.1038/s414...
Highly recommended!
08.08.2025 11:52 β π 0 π 1 π¬ 0 π 0Highly recommended!
08.08.2025 11:52 β π 0 π 1 π¬ 0 π 0π 2025β―DFCI TPD event registration is open!
πβ―Sepβ―11, 11:30β―AMβ8β―PMβ―ET, Boston
πβ―Keynote: Nathanaelβ―Gray
πβ―Registration link: forms.gle/NLUSa51Btrtf...
#TPD #ProteinDegradation #DrugDiscovery #Boston #DFCI
getting less stickyβ¦
www.science.org/doi/10.1126/...
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
The legendary EMBO Integrative Modeling Course is back! If you want to be in this picture in the 2025 edition, just go ahead and register at meetings.embo.org/event/25-bio...
Organized by myself & @amjjbonvin.bsky.social & @arneelof.bsky.social & @lindorfflarsen.bsky.social
Five people at a restaurant table, looking in to the camera and smiling.
Great day & night discussing how to design impactful drugs π with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers π»!
Unfinished Symphony
@icr.ac.uk @temt-icr.bsky.social
youtu.be/yjelh9iQWMA?...
A timely and useful JMC Perspective: St John-Campbell & Bhalay (2025) Target Engagement Assays in Early #DrugDiscovery | #OpenAccess #MedChem #ChemBiol #DrugDesign #cheminformatics #chemsky π§ͺ
doi.org/10.1021/acs....
New review from authors Annabel Cardno, Bryony Kennedy, and Catherine Lindon from University of Cambridge comes a review of the important aspects to consider for obtaining optimal degrader activity. From localization to activity of ligase to target accessibility!
www.nature.com/articles/s42...
The SMR @socmedres.bsky.social is a non-profit UK organisation that brings together great pharma industry, biotech, academia and funders communities to foster excellence in drug discovery. Highly recommended.
11.04.2025 21:38 β π 1 π 0 π¬ 1 π 0The SMR @socmedres.bsky.social brings together great research communities from academia and industry. Highly recommended! π
11.04.2025 21:21 β π 0 π 0 π¬ 0 π 0New preprint out co-led by Hannah Lloyd and Christina Woo at Harvard along with colleagues at the Broad and CeTPD Dundee gives insight on how to detect and discover native substrates of CRBN!
www.biorxiv.org/content/10.1...
π Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!
www.cell.com/cell/fulltex...
Kudos to all colleagues at the Institute of Caner Research! Proud to be part of the team! @icr.ac.uk
27.03.2025 23:31 β π 3 π 0 π¬ 0 π 0πππ Join our cancer drug discovery team in London-Sutton! πππ
Weβre looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If youβre seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR
Great opportunity for experienced cancer biology drug discovery leaders π£π£π£
18.03.2025 22:05 β π 2 π 1 π¬ 0 π 0π£ Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 πππ
π World-class Speakers
π Cutting-edge Insights
π Networking Opportunities
π
Date: 21st March 2025
π Location: GSK Stevenage, UK
π Register here: www.smr.org.uk/Meetings/202...
December 2022, at the Humanitarian Hub at London Stansted Airport supporting refugees fleeing the war in Ukraine πππͺπΊπͺπΊπͺπΊπͺπΊ
09.03.2025 23:22 β π 2 π 0 π¬ 0 π 0πππ Join our cancer drug discovery team in London-Sutton! πππ
Weβre looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If youβre seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR
It would be *spun* as political, but the challenge to the RS is whether it has the courage to stand by the values of science its code of conduct requires of all Fellows. Without that, how can it maintain its claim to speak for the wider scientific community? www.theguardian.com/science/2025...
07.03.2025 14:56 β π 183 π 48 π¬ 18 π 20πSpeaker Spotlight: 2nd SMR Molecular Glues Meetingπ
We are excited to welcome Dr Katherine Donovan @katherinedonovan.bsky.social from @danafarber.bsky.social as one of our distinguished speakers!
π
21st March 2025
π GSK Stevenage, UK
π lnkd.in/dNwWVtwE
Join us at this exceptional event!
π Speaker Spotlight: 2nd SMR Molecular Glues Meetingπ
We are excited to welcome Dr Ingo Kober from Merck KGaA in Darmstadt, Germany as one of our distinguished speakers!
π
21st March 2025
π GSK Stevenage, UK
π lnkd.in/dNwWVtwE
Don't miss out - register now and be part of this exceptional event!
π Speaker Spotlight: 2nd SMR Molecular Glues Meetingπ
We are excited to welcome Dr Aneika Leney from University of Birmingham, UK as one of our distinguished speakers!
π
21st March 2025
π GSK Stevenage, UK
π Registration: lnkd.in/dNwWVtwE
Two weeks to go! The 2nd SMR Molecular Glues Meeting πππ
π World-class speakers
π Cutting-edge insights
π Networking opportunities
π
Date: 21st March 2025
π Location: GSK Stevenage, UK
π Register here: www.smr.org.uk/Meetings/202...