Sierra Palumbos

Together, we describe two compensatory secretion pathways that could be important to delay neurodegeneration. However, prolonged upregulation of these pathways could contribute to neuroinflammation.

Additionally, we show the release of exosomes is upregulated and that this release is critical to stave off apoptosis

We find that the secretion of LC3+ autophagic membrane extracellular vesicles (SLAM-EVs) is upregulated in neurons harboring a Parkinson's disease causing mutation

SLAM-EVs contain known autophagic cargos including mitochondria and synaptic proteins

Very excited to share my postdoc work- out now at PNAS!

Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways

Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

This is going to hurt science. 🧪

What hurts science hurts healthcare. 🩺

What hurts healthcare hurts you. 🫵

Call, email, and if possible visit, your representatives. This is personal whether you want it to be or not.

Very good source to understand indirect costs by Sally Rockey, former Deputy Director for Extramural Activities at NIH.

Very thorough and clear.

If you want to understand indirect costs or have family or friends who are pestering you to explain IDC, send them this...

www.aau.edu/key-issues/i...

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants.

grants.nih.gov/grants/guide...

⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.

—> Deep budget cuts & program closures coming to a university near you.

Is this the break the glass moment for university administrators who have been silent so far about the attack on science?

Revised and Extended: What's Happening Inside the NIH and NSF

Revised and Extended: What's Happening Inside the NIH and NSF | Science | AAAS www.science.org/content/blog...

Shout out to Dr. Bishal Basak in @erikaholzbaur.bsky.social at @upenn.bsky.social for spearheading the work on identifying a new stress response pathway that regulates mitophagy in neurons!
➡️Read pre-print here: doi.org/10.1101/2024...

If you’re a federal govt employee targeted for leave or termination on the basis of your DEI work, please file an EEO (Equal Employment Opportunity) complaint & retain legal counsel.

I’m a former NIH PI. Happy to refer you to a law firm that has successfully sued the govt many times!

Pls repost 🙏❤️

NIH In Your State - United For Medical Research Select a state on the map to see the impact of NIH funding across America.

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

Step 1) find your rep

www.congress.gov/members/find...

Step 2) send an email or call their office

Step 3) tell them that federal spending on scientific advancement is the best hope we have to “win against china” or whatever these guys are obsessed with these days

Study sections are the review panels that allocate NIH research grants. They bring in experts from around the country and have to be scheduled many months in advance; they provide the funds that keep the nation's biomedical research going.

It's hard to overstate the disruption this causes.

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

The United States built a publicly funded scientific enterprise that worked miracles. We went to the moon and mars, laid the groundwork for computing revolutions, turned AIDS from a death sentence to a chronic condition, drastically cut cancer deaths. And now we're just going to dismantle it?

FIB-SEM dataset visualized with Microscopy Nodes, data from Mocaer et al 2023

Microscopy Nodes is now up on bioRxiv! 🚀

This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev).

High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬

www.biorxiv.org/content/10.1...

thank you, Xilma!

📣Now that @mito911.bsky.social is on Bluesky, let's highlight the research run in our team! Check out the pre-print by @palumbos.bsky.social Palumbos et al. and colleagues from the @erikaholzbaur.bsky.social!
@asapresearch.bsky.social
⬇️

Read the recent pre-print by @palumbos.bsky.social now on BioRxiv. In the meanwhile, find below and read a thread for a sweet preview of her work! 👩‍🔬 🧫
@asapresearch.bsky.social

Free Neuroscience Textbooks and Online Tutorials Free Neuroscience Textbooks and Online Tutorials (Compiled by Carlos Aizenman, Brown University, Dept. of Neuroscience) Maintaining a current list of digital educational resources is tricky. Softwar...

Do you teach neuroscience? Here’s a list I’ve compiled of mostly free online neuroscience textbooks, simulations and datasets you can use for your course! If I’m missing something, let me know so I can add it! docs.google.com/document/d/1...

Would love to be added!

Been waiting for this one! Thank you!

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib

Events Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...

If you are interested in mitochondria, mitophagy and/or PD follow the mito911 Webinar series! Events calendar and registration at this link parkinsonsroadmap.org/events/

Just going in to lab hoping no one in Congress notices me feeding mice little sweet treats to see if they really want it or just merely like it

Autophagic stress activates distinct compensatory secretory pathways in neurons Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...

Excited to share this new preprint from Sierra Palumbos, tracking the effects of dysfunctional autophagy in neurons: www.biorxiv.org/content/10.1...

FMRP regulates MFF translation to locally direct mitochondrial fission in neurons - Nature Cell Biology Fenton et al. show that FMRP granules dock at the mitochondrial midzone in a Rab7-dependent manner in axons and dendrites, where they promote local MFF synthesis and fission at the mitochondrial midzo...

So proud of Adam Fenton and his work defining the role of FMRP in the local regulation of mitochondrial fission in neurons via local translation: www.nature.com/articles/s41...

We propose that these secretion pathways likely have short term benefits to the LRRK2 neurons, but that over extended periods, elevated release of proinflammatory factors could contribute to disease progression.

First, we observe the increased release of secreted autophagosomes which likely mediates waste disposal. Additionally, we observe the upregulated release of exosomes containing miRNAs, likely critical for transcellular communication.